Search Results
Search for other papers by Esteban Grasso in
Google Scholar
PubMed
Search for other papers by Daniel Paparini in
Google Scholar
PubMed
Search for other papers by Mariana Agüero in
Google Scholar
PubMed
Search for other papers by Gil Mor in
Google Scholar
PubMed
Search for other papers by Claudia Pérez Leirós in
Google Scholar
PubMed
Search for other papers by Rosanna Ramhorst in
Google Scholar
PubMed
-privileged site supporting the nidation of a semiallogenic fetus ( Gellersen & Brosens 2003 , Mesiano et al . 2011 ). The decidualization of the stromal cells also occurs in the absence of pregnancy and the declining P 4 levels trigger several effects, such as
Department of Biology, Shantou University, Shantou, China
Search for other papers by Jie Liu in
Google Scholar
PubMed
Search for other papers by Fei Gao in
Google Scholar
PubMed
Search for other papers by Yue-Fang Liu in
Google Scholar
PubMed
Search for other papers by Hai-Ting Dou in
Google Scholar
PubMed
Search for other papers by Jia-Qi Yan in
Google Scholar
PubMed
Search for other papers by Zong-Min Fan in
Google Scholar
PubMed
Search for other papers by Zeng-Ming Yang in
Google Scholar
PubMed
Introduction Embryo implantation is the attachment of the embryo to the uterine luminal epithelium followed by invasion of embryos into the underlying stromal bed. Once embryos are implanted, uterine stromal cells will undergo decidualization
Search for other papers by Amanda L Patterson in
Google Scholar
PubMed
Search for other papers by Jamieson Pirochta in
Google Scholar
PubMed
Search for other papers by Stephanie Y Tufano in
Google Scholar
PubMed
Search for other papers by Jose M Teixeira in
Google Scholar
PubMed
Introduction Two of the most crucial events in early pregnancy in species with invasively implanting embryos, such as humans and mice, are embryo implantation and endometrial decidualization. Embryo implantation is a tightly regulated series
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
Search for other papers by Vinay Shukla in
Google Scholar
PubMed
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
Search for other papers by Jyoti Bala Kaushal in
Google Scholar
PubMed
Search for other papers by Pushplata Sankhwar in
Google Scholar
PubMed
Search for other papers by Murli Manohar in
Google Scholar
PubMed
Academy of Scientific and Innovative Research (AcSIR), CSIR-CDRI Campus, Lucknow, India
Search for other papers by Anila Dwivedi in
Google Scholar
PubMed
Introduction Decidualization of endometrial stromal cells (ESCs) is the hallmark of tissue remodeling which supports embryo implantation and proper placental development ( Gellersen & Brosens 2014 , Yu et al. 2017 , Liu et al. 2017
Search for other papers by Hai-Fan Yu in
Google Scholar
PubMed
Search for other papers by Zhan-Peng Yue in
Google Scholar
PubMed
Search for other papers by Kai Wang in
Google Scholar
PubMed
Search for other papers by Zhan-Qing Yang in
Google Scholar
PubMed
Search for other papers by Hong-Liang Zhang in
Google Scholar
PubMed
Search for other papers by Shuang Geng in
Google Scholar
PubMed
Search for other papers by Bin Guo in
Google Scholar
PubMed
Introduction Decidualization, a process where uterine stromal cells undergo extensive proliferation and differentiation into decidual cells, is essential for continued embryonic development and successful pregnancy ( Dey et al . 2004 , Zhang
Search for other papers by Dang-Dang Li in
Google Scholar
PubMed
Search for other papers by Ying-Jie Gao in
Google Scholar
PubMed
Search for other papers by Xue-Chao Tian in
Google Scholar
PubMed
Search for other papers by Zhan-Qing Yang in
Google Scholar
PubMed
Search for other papers by Hang Cao in
Google Scholar
PubMed
Search for other papers by Qiao-Ling Zhang in
Google Scholar
PubMed
Search for other papers by Bin Guo in
Google Scholar
PubMed
Search for other papers by Zhan-Peng Yue in
Google Scholar
PubMed
be regulated by Hoxa10 gene, which was essential for decidualization ( Benson et al . 1996 , Germeyer et al . 2009 , Doherty et al . 2011 , Zhang et al . 2013 ). According to our (B Guo and X-C Tian unpublished observations) microarray data
Search for other papers by L Grinius in
Google Scholar
PubMed
Search for other papers by C Kessler in
Google Scholar
PubMed
Search for other papers by J Schroeder in
Google Scholar
PubMed
Search for other papers by S Handwerger in
Google Scholar
PubMed
Accili & Arden 2004 ). Several lines of evidence suggest that one of the family members, FOXO1A (forkhead box O1A (rhabdomyosarcoma), also known as FKHD and FKH1), is involved in the regulation of human uterine decidualization. DNA microarray studies have
Search for other papers by B Gellersen in
Google Scholar
PubMed
Search for other papers by J Brosens in
Google Scholar
PubMed
During the menstrual cycle, the ovarian hormones oestradiol and progesterone control the ordered growth and differentiation of uterine cells. This remodelling process is critical for implantation of the developing embryo, the formation of the placenta, and maintenance of pregnancy. Failure of uterine tIssues to respond appropriately to ovarian hormone signalling results in defective placentation, associated with a spectrum of pregnancy disorders such as recurrent miscarriages and preeclampsia. These obstetrical disorders are a major cause of maternal and perinatal morbidity and mortality. Progesterone exerts its action on target cells, at least in part, through binding to the progesterone receptor (PR), a member of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. The mechanism by which progesterone controls the differentiation of human endometrial stromal cells, a process termed decidualization, in the secretory phase of the menstrual cycle is not well understood. Emerging evidence indicates that locally expressed factors and activation of the cAMP second messenger pathway integrate hormonal inputs and confer cellular specificity to progesterone action through the induction of diverse transcription factors capable of modulating PR function.
Division of Parasitology, Central Drug Research Institute, Lucknow, India
Search for other papers by A Makker in
Google Scholar
PubMed
Division of Parasitology, Central Drug Research Institute, Lucknow, India
Search for other papers by F W Bansode in
Google Scholar
PubMed
Division of Parasitology, Central Drug Research Institute, Lucknow, India
Search for other papers by V M L Srivastava in
Google Scholar
PubMed
Division of Parasitology, Central Drug Research Institute, Lucknow, India
Search for other papers by M M Singh in
Google Scholar
PubMed
permeability, a non-genomic response of estrogen action, necessary for initiation of implantation and decidualization ( Laloraya et al. 1989 ). A role has been demonstrated for ovarian steroids, primarily estrogen, in the modulation of infiltration and
Molecular Medicine Research Labs, Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba-shi, Ibaraki 305-8585, Japan
Search for other papers by Pei-Jian He in
Google Scholar
PubMed
Molecular Medicine Research Labs, Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba-shi, Ibaraki 305-8585, Japan
Search for other papers by Masami Hirata in
Google Scholar
PubMed
Molecular Medicine Research Labs, Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba-shi, Ibaraki 305-8585, Japan
Search for other papers by Nobuhiko Yamauchi in
Google Scholar
PubMed
Molecular Medicine Research Labs, Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba-shi, Ibaraki 305-8585, Japan
Search for other papers by Seiichi Hashimoto in
Google Scholar
PubMed
Molecular Medicine Research Labs, Drug Discovery Research, Astellas Pharma Inc., Miyukigaoka 21, Tsukuba-shi, Ibaraki 305-8585, Japan
Search for other papers by Masa-aki Hattori in
Google Scholar
PubMed
another highly dynamic tissue. In rodents, the endometrial stromal cells undergo proliferation and decidualization in response to steroid hormones and blastocyst implantation at the early stage of pregnancy ( Dey et al. 2004 ). In the mammalian
