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Xuemei Tang, Jingwen Li, Wei Xiang, Ye Cui, Bin Xie, Xiaodong Wang, Zihui Xu and Lixia Gan

, leptin directly acts on liver, muscle or pancreas to promote fat oxidation ( Muoio & Lynis Dohm 2002 ) or inhibiting insulin secretion ( Marroquí et al . 2012 ). Mutations in the functional leptin (ob/ob) or leptin receptors gene (db/db) in mice and

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Frank Peelman, Lennart Zabeau, Kedar Moharana, Savvas N Savvides and Jan Tavernier

Introduction Leptin and the leptin receptor (LR) are essential components in the complex genetic wiring diagram underlying energy homeostasis and body weight. The hormone is now known to participate in a wide range of biological functions including

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Gideon Hen, Sera Yosefi, Ana Ronin, Paz Einat, Charles I Rosenblum, Robert J Denver and Miriam Friedman-Einat

Introduction The chicken leptin receptor (CLEPR) gene, which has been cloned in our laboratory ( Horev et al . 2000 ) and by others ( Ohkubo et al . 2000 ), was the first leptin receptor (LEPR) cloned in a nonmammalian organism. It exhibits about

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M Matheny, K Y E Strehler, M King, N Tümer and P J Scarpace

leptin overexpression impinge upon a distributed neural network that includes an integration of leptin activity in many, if not all brain regions bearing functional leptin receptors. It is currently unclear if leptin function in an individual brain region

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Hiromi Adachi, Yasumasa Takemoto, Takashi Bungo and Takeshi Ohkubo

specific receptor located in the target tissues and the leptin receptor (LEPR) belongs to the class I cytokine receptor superfamily that shares common structural features and signal transduction pathways ( Tartaglia et al . 1995 ). The LEPR is known to

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Amanda L Gruver, Melissa S Ventevogel and Gregory D Sempowski

). Interestingly, mice with naturally occurring mutations in leptin ( ob/ob mice) or membrane-bound leptin receptor ( db/db mice) also suggest a role for leptin in immune function. Leptin-deficient ob/ob mice exhibit chronic thymic atrophy, suppressed cell

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Dario A Gutierrez and Alyssa H Hasty

( Halaas et al . 1995 , Coenen et al . 2007 ). Leptin acts primarily through the long form of the leptin receptor (LepR) and plays an important role in weight regulation through its action in the hypothalamus ( Leshan et al . 2006 ). Mice that lack

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Hui Yu, Zoe Thompson, Sylee Kiran, Graham L Jones, Lakshmi Mundada, Surbhi, Marcelo Rubinstein and Malcolm J Low

) and insulin to control energy and glucose homeostasis ( Varela & Horvath 2012 ). Leptin targets cells expressing multiple leptin receptor isoforms, including a subpopulation of ARC POMC neurons. The full-length leptin receptor (LEPRB) is responsible

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S C P Dutra, E G Moura, A L Rodrigues, P C Lisboa, I Bonomo, F P Toste and M C F Passos

TSH ( Legradi et al . 1997 , Nillni et al . 2000 , Ortiga-Carvalho et al . 2002 ), or directly upon its receptors on the thyroid, increasing TH secretion ( Nowak et al . 2002 ). Leptin receptors are present in the hypothalamus ( Tartaglia 1997

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M B Mazzucco, R Higa, E Capobianco, M Kurtz, A Jawerbaum and V White

et al . 2001 ). Leptin is produced mainly by adipocytes in response to insulin signaling and lipid accumulation ( Maiorana et al . 2007 ). As a result of alternative splicing, leptin receptor ( Lepr ) has six isoforms (a–f) ( Tartaglia 1997 ). The e