FFA uptake, de novo lipogenesis (DNL), and/or reduced lipid removal. ( Dowman et al. 2010 , Pettinelli et al. 2011 , Berlanga et al. 2014 ). The development of hepatic steatosis in PCOS is unique due to the influence of HA and is multi
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Tina Seidu, Patrick McWhorter, Jessie Myer, Rabita Alamgir, Nicole Eregha, Dilip Bogle, Taylor Lofton, Carolyn Ecelbarger, and Stanley Andrisse
Min Liu, Shuo Xie, Weiwei Liu, Jingjin Li, Chao Li, Wei Huang, Hexin Li, Jinghai Song, and Hong Zhang
lipogenesis and adipogenesis ( Musso et al . 2013 ). Adipose tissue includes adipocytes and a stromal-vascular fraction comprising preadipocytes, fibroblasts, endothelial cells, macrophages, and other immune cells. There are generally two types of adipose
Chunchun Wei, Xianhua Ma, Kai Su, Shasha Qi, Yuangang Zhu, Junjian Lin, Chenxin Wang, Rui Yang, Xiaowei Chen, Weizhong Wang, and Weiping J Zhang
adaptation. Lipoprotein lipase (LPL) is dramatically upregulated during BAT activation to promote uptake of free fatty acids from circulation. β-oxidation can directly provide acetyl-CoA for thermogenesis. However, de novo lipogenesis (DNL) genes, such as
Cho-Rong Bae, Kazuya Hasegawa, Sayaka Akieda-Asai, Yurie Kawasaki, Kazuyo Senba, Youn-Soo Cha, and Yukari Date
lipogenesis, we evaluated the expression of sterol regulatory element-binding transcription factor 1 (SREBF1), carbohydrate-responsive element-binding protein (ChREBP; MLX1PL), and acetyl-CoA carboxylase (ACC) and the phosphorylation of ACC by using western
Bettina Geidl-Flueck and Philipp A Gerber
hypothesized that an increased de novo lipogenesis after fructose intake in parallel with a decreased fatty acid oxidation leads to hepatic fat deposition. ACC, acetyl-CoA-carboxylase; ATP, adenosine triphosphate; CPT1a, carnitine palmitoyltransferase 1A; FA
Paul W Caton, Nanda K Nayuni, Noorafza Q Khan, Elizabeth G Wood, and Roger Corder
et al . 2005 , Bilz et al . 2006 , Rajasekar & Anuradha 2007 , Nagai et al . 2009 ). In humans, consumption of a fructose-rich diet causes insulin resistance, increases uric acid, and stimulates de novo lipogenesis, resulting in increased
A I Martín, E Castillero, M Granado, M López-Menduiña, M A Villanúa, and A López-Calderón
fat stores is not well known. Fat mass loss can be secondary to an increase in lipolysis and/or a decrease in lipogenesis. Lipolysis in WAT is under hormonal control, where the hormone-sensitive lipase (HSL) is the main regulatory pathway in rodent
Christophe Breton
binds to MC4 receptor (MC4R) acts on the opposite way, thereby decreasing food intake and increasing energy expenditure. The adipocyte is a specialised cell that stores excess energy as triacylglycerol (TG) in lipid droplets during lipogenesis. When
Sébastien Desarzens and Nourdine Faresse
in lipogenesis, inflammation and secreted adipokines in diet-induced obese Gr fl/fl and Gr ad-ko mice. As shown in Fig. 5A , Gr deletion has a slight or no effects on lipogenic genes as well as adipokines expression. However, pro
Ken Takao, Katsumi Iizuka, Yanyan Liu, Teruaki Sakurai, Sodai Kubota, Saki Kubota-Okamoto, Toshinori Imaizumi, Yoshihiro Takahashi, Yermek Rakhat, Satoko Komori, Tokuyuki Hirose, Kenta Nonomura, Takehiro Kato, Masami Mizuno, Tetsuya Suwa, Yukio Horikawa, Masakatsu Sone, and Daisuke Yabe
hepatic lipogenesis is impaired in Chrebp −/− mice, which have reduced hepatic triglyceride content and reduced plasma triglyceride levels ( Iizuka et al. 2004 ). Interestingly, Chrebp −/− mice show reduced plasma cholesterol levels due to decreased
