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Samuel Richard Heaselgrave S Heaselgrave, Center of Hypothalamic Research, The University of Texas Southwestern Medical Center Department of Internal Medicine, Dallas, United States

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Silke Heising S Heising, Institute for Metabolism and Systems Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland

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Stuart Andrew Morgan S Morgan, Institute of Metabolism and Systems Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland

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David M Cartwright D Cartwright, Institute of Metabolism and Systems Research, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland

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Michael S Sagmeister M Sagmeister , Institute of Inflammation and Ageing, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland

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Rowan Hardy R Hardy, Institute of Inflammation and Ageing, University of Birmingham College of Medical and Dental Sciences, Birmingham, United Kingdom of Great Britain and Northern Ireland

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Craig L Doig C Doig, Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, Nottingham Trent University, Nottingham, United Kingdom of Great Britain and Northern Ireland

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Nicholas Morton N Morton, Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences , Nottingham Trent University, Nottingham, United Kingdom of Great Britain and Northern Ireland

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Kostas Tsintzas K Tsintzas, School of Life Sciences, University of Nottingham Faculty of Medicine and Health Sciences, Nottingham, United Kingdom of Great Britain and Northern Ireland

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Gareth G Lavery G Lavery, Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences , Nottingham Trent University, Nottingham, United Kingdom of Great Britain and Northern Ireland

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Systemic glucocorticoid excess causes several adverse metabolic conditions, most notably Cushing’s syndrome. These effects are amplified by the intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Here we determined the less well characterised effects of glucocorticoid excess, and the contribution of 11β-HSD1 amplification, on metabolic rate in mice. Male and female C57BL/6J (wild type, WT) and 11β-HSD1 knock out (11β-HSD1KO) mice were treated with high-dose corticosterone or a vehicle control for 3 weeks. Indirect calorimetry was conducted during the final week of treatment, with or without fasting, to determine the impact on metabolic rate. We found that corticosterone treatment elevated metabolic rate and promoted carbohydrate utilisation primarily in female WT mice, with effects more pronounced during the light phase. Corticosterone treatment also resulted in greater fat accumulation in female WT mice. Corticosterone induced hyperphagia was identified as a likely causal factor altering the respiratory exchange ratio (RER) but not energy expenditure (EE). Male and female 11β-HSD1KO mice were protected against these effects. We identify novel metabolic consequences of sustained glucocorticoid excess, identify a key mechanism of hyperphagia and demonstrate that 11β-HSD1 is required to manifest the full metabolic derangement.

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0205
Volume/Issue:
Accepted Manuscripts
Open access
Victoria Diedrich Institute of Neurobiology, Ulm University, Ulm, Germany

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Elena Haugg Institute of Neurobiology, Ulm University, Ulm, Germany

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Carola Dreier Institute of Neurobiology, Ulm University, Ulm, Germany

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Annika Herwig Institute of Neurobiology, Ulm University, Ulm, Germany

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resting metabolic rate. They can tolerate the resulting severe decrease in body temperature and thereby save large amounts of energy (up to 98%). Different forms of metabolic depression exist, ranging from obligate, deep hibernation, characterized by 96

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0502
Volume/Issue:
Volume 244: Issue 2
Free access
Renata Lopes Araujo
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Bruno Moulin de Andrade
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Álvaro Souto Padron de Figueiredo
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Monique Leandro da Silva
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Michelle Porto Marassi
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Valmara dos Santos Pereira
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Eliete Bouskela Laboratório de Fisiologia Endócrina do Instituto de Biofísica Carlos Chagas Filho, Laboratório de Pesquisas em Microcirculação, Universidade Federal do Rio de Janeiro, Rio de Janeiro, CEP 21949-900, Brazil

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Denise P Carvalho
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decrease in basal metabolic rate ( Ravucin et al . 1985 , Rosenbaum et al . 2002 ). The responses to food restriction have been well documented in a number of species, including humans ( Kelley et al . 1993 ), monkeys ( Kemnitz et al . 1994 ), rats

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0125
Volume/Issue:
Volume 198: Issue 1
Free access
Abdoulaye Diané Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Nikolina Nikolic Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Alexander P Rudecki Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Shannon M King Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Drew J Bowie Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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Sarah L Gray Northern Medical Program, University of Northern British Columbia, 3333 University Way, Prince George, British Columbia, Canada V2N 4Z9

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-induced thermogenesis in Pacap −/− mice Pacap −/− and Pacap +/+ mice were paired and housed together according to age and gender. Resting and maximal metabolic rates (MMR) were measured in 8-week-old mice reared at 24 °C. These mice were then acclimated at 18 °C

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0316
Volume/Issue:
Volume 222: Issue 3
Free access
Kishor Devalaraja-Narashimha Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA

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Babu J Padanilam Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA
Department of Cellular and Integrative Physiology, Section of Nephrology, Department of Internal Medicine, University of Nebraska Medical Center, 985850 Nebraska Medical Center, Omaha, Nebraska 68198-5850, USA

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with WT mice on high-fat diet ( n =7–8). Basal metabolic rate and energy expenditure are decreased in Parp -KO mice. (B) Comparison of the oxygen consumption for a period of 24 h for WT and Parp -KO mice that were fed HF diet for 19 weeks. (C

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0402
Volume/Issue:
Volume 205: Issue 3
Free access
Nailliw Z Preite Center of Biological and Health Sciences, Mackenzie Presbyterian University, Sao Paulo, SP, Brazil
Department of Translational Medicine, EPM, Federal University of Sao Paulo, Sao Paulo, SP, Brazil

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Bruna P P do Nascimento Center of Biological and Health Sciences, Mackenzie Presbyterian University, Sao Paulo, SP, Brazil
Department of Translational Medicine, EPM, Federal University of Sao Paulo, Sao Paulo, SP, Brazil

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Cynthia R Muller Experimental Pathophysiology Department, Faculty of Medicine, University of Sao Paulo, SP, Brazil

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Anna Laura V Américo Experimental Pathophysiology Department, Faculty of Medicine, University of Sao Paulo, SP, Brazil

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Talita S Higa School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil

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Fabiana S Evangelista School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, SP, Brazil

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Carmen L Lancellotti Department of Pathology, School of Medical Sciences, Santa Casa, São Paulo, SP, Brazil

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Felipe dos Santos Henriques Laboratory of Adipose Tissue Biology, Integrated Group of Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, SP, Brazil

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Miguel Luiz Batista Jr Laboratory of Adipose Tissue Biology, Integrated Group of Biotechnology, University of Mogi das Cruzes, Mogi das Cruzes, SP, Brazil

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Antonio C Bianco Division of Endocrinology and Metabolism, Department of Internal Medicine, Rush University and Medical Center, Chicago, Illinois, USA

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Miriam O Ribeiro Center of Biological and Health Sciences, Mackenzie Presbyterian University, Sao Paulo, SP, Brazil

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Introduction A balance between food intake and energy expenditure is essential to preserve fuel homeostasis. Changes in caloric intake trigger physiological responses that include adaptive modifications in appetite, metabolic rate and energy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0199
Volume/Issue:
Volume 231: Issue 3
Free access
Beatriz S Amorim Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil
Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Cintia B Ueta Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil
Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Beatriz C G Freitas Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Renata J Nassif Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Cecília Helena de Azevedo Gouveia Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Marcelo A Christoffolete Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Anselmo S Moriscot Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Carmen Lucia Lancelloti Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Flávia Llimona Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Hermes Vieira Barbeiro Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Heraldo Possolo de Souza Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Sergio Catanozi Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Marisa Passarelli Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Marcelo S Aoki Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Antonio C Bianco Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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Miriam O Ribeiro Biological Science Course, Division of Endocrinology, Department of Anatomy, Department of Cell and Developmental Biology, Lipids Laboratory (LIM 10) Faculty of Medical Sciences, Clinical Emergency, School of Arts, AFIP and Pathology, CCBS, Presbyterian University Mackenzie, Rua da Consolação, 930 Prédio 38, Curso de Biologia, São Paulo, SP 01302-907, Brazil

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period, animals were studied for resting metabolic rate (RMR), glucose tolerance test (GTT), and insulin tolerance test (ITT). Animals were subsequently killed by exsanguinations under urethane anesthesia, and blood processed for plasma isolation and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0539
Volume/Issue:
Volume 203: Issue 2
Free access
Alvaro Souto Padron Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Ruy Andrade Louzada Neto Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil
Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Thiago Urgal Pantaleão Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Maria Carolina de Souza dos Santos Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Renata Lopes Araujo Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Bruno Moulin de Andrade Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Monique da Silva Leandro Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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João Pedro Saar Werneck de Castro Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Andrea Claudia Freitas Ferreira Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Denise Pires de Carvalho Laboratório de Fisiologia Endócrina Doris Rosenthal, Laboratório de Biologia do Exercício, Instituto de Biofísica Carlos Chagas Filho and Instituto de Pesquisa Translacional em Saúde e Ambiente na Região Amazônica (INPeTAM), CCS-Bloco G- Cidade Universitria, Ilha do Fundo, Rio de Janeiro 21949-900, Brazil

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Introduction Compound 3,3′,5-triiodothyronine (T 3 ) exerts many important effects on the basal metabolic rate and increases oxygen consumption. Several years ago, it was shown that 3,5-diiodothyronine (3,5-T2) is responsible for certain non

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0502
Volume/Issue:
Volume 221: Issue 3
Open access
Mutaz Musa Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3

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Shannon M Fernando Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3

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Diptendu Chatterjee Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3

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D Ashley Monks Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3
Institute of Medical Science, Department of Psychology, University of Toronto, Toronto, Ontario, Canada M5S 3G3

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have marked increases in diaphorase staining of muscle fibers, suggestive of hypermetabolism ( Monks et al . 2007 ). Indeed, HSA-AR rats exhibit increased resting metabolic rate (RMR) as well as increased electron transport chain (ETC) activity within

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0071
Volume/Issue:
Volume 210: Issue 1
Free access
J Naufahu Faculty of Science and Technology, University of Westminster, London, UK

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F Alzaid Faculty of Science and Technology, University of Westminster, London, UK

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M Fiuza Brito Faculty of Science and Technology, University of Westminster, London, UK

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B Doslikova Faculty of Science and Technology, University of Westminster, London, UK

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T Valencia Faculty of Science and Technology, University of Westminster, London, UK

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A Cunliffe Faculty of Science and Technology, University of Westminster, London, UK

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J F Murray Faculty of Science and Technology, University of Westminster, London, UK

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increased metabolic rate, increased locomotor activity or both ( Shimada et al. 1998 , Segal-Lieberman et al. 2003 ). MCH is expressed in the central nervous system (CNS), primarily in the rostral zona incerta/incerto-hypothalamic and the lateral

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0240
Volume/Issue:
Volume 232: Issue 3
Free access