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Lucia Gajdosechova, Katarina Krskova, Ana Belen Segarra, Andrea Spolcova, Maciej Suski, Rafal Olszanecki and Stefan Zorad

et al . 2011 , Morton et al . 2012 , Zhang et al . 2013 ). In vivo physiological levels of circulating oxytocin depend on its synthesis, receptor-mediated internalisation and degradation by oxytocinase. Oxytocinase (cystinyl aminopeptidase, EC 3

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Gareth Leng, Rafael Pineda, Nancy Sabatier and Mike Ludwig

-feedback manner to support parturition. However, by the end of the 1950s and the beginning of the 1960s, it was recognised that the plasma of pregnant women contained an enzyme – oxytocinase – that could potently degrade oxytocin and that the levels of oxytocinase

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Rafaela Fadoni Alponti, Patricia Lucio Alves and Paulo Flavio Silveira

Introduction EC 3.4.11.3 protein (IRAP, insulin-regulated aminopeptidase), also known as vp165, GP160 ( Keller 2004 ), placental leucine aminopeptidase (AP) ( Mizutani et al . 2011 ), cystyl AP, oxytocinase ( Rogi et al . 1996 ), and angiotensin