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James C Needell Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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Madalyn N Brown Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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Danny Zipris Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA

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this study were approved by the Institutional Animal Care and Use Committee of the University of Colorado Denver. KRV was propagated and tittered as previously described ( Zipris et al . 2005 ). Virus, Poly (I:C) and dexamethasone treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0131
Volume/Issue:
Volume 238: Issue 1
Free access
Chun Zeng Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Xin Yi Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Danny Zipris Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Hongli Liu Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Lin Zhang Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Qiaoyun Zheng Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Krishnamurthy Malathi Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Ge Jin Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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Aimin Zhou Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA
Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA
Clinical Chemistry Program, Center for Gene Regulation in Health and Diseases, Department of Cancer Biology, Barbara Davis Center of Childhood Diabetes, Central Laboratory, Department of Biological Sciences, Department of Biological Sciences, Department of Chemistry, Cleveland State University, SI 424, Cleveland, Ohio 44115, USA

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al . 1994 ). In addition, IFNα mediates induction of type 1 diabetes by poly I:C in mice expressing the B7.1 costimulatory molecule driven by the rat insulin promoter (RIP) on β-cells in islets ( Devendra et al . 2005 ). Most recently, a study has

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0509
Volume/Issue:
Volume 223: Issue 3
Free access
Shisan Xu Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Fangjing Xie Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Li Tian Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Samane Fallah Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Fatemeh Babaei Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Sinai H C Manno Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Francis A M Manno III School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, New South Wales, Australia

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Lina Zhu Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Kin Fung Wong Department of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Yimin Liang Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Rajkumar Ramalingam Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Lei Sun Department of Biomedical Engineering, Polytechnic University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Xin Wang Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Robert Plumb Waters Technologies Corporation, Milford, Massachusetts, USA

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Lee Gethings Waters Technologies Corporation, Milford, Massachusetts, USA

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Yun Wah Lam Department of Chemistry, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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Shuk Han Cheng Department of Biomedical Sciences, College of Veterinary Medicine and Life Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China
State Key Laboratory of Marine Pollution (SKLMP) at City University of Hong Kong, Hong Kong SAR, People’s Republic of China
Department of Materials Science and Engineering, College of Science and Engineering, City University of Hong Kong, Hong Kong SAR, People’s Republic of China

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( Lai et al . 2017 ). These authors also discovered that treatment with poly I:C, a viral mimic known to stimulate ifn-γ -responsive genes ( Farina et al . 2010 ), can enable heart regeneration in medaka, a species normally unable to repair heart

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0413
Volume/Issue:
Volume 245: Issue 1
Open access
Kaitlyn A Colglazier Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, Indiana, USA

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Noyonika Mukherjee Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA

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Christopher J Contreras Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, Indiana, USA

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Andrew T Templin Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, Indiana, USA
Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, Indiana, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA

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pyrin domain containing 3 PRR Pattern-recognition receptors NLR NOD-like receptor Poly I:C Polyinosinic:polycytidylic acid a Key abbreviations mentioned within the review in the order mentioned. There is a

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0378
Volume/Issue:
Volume 262: Issue 2
Open access