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Alejandro Ibáñez-Costa Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK

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of pituitary tumours and very rarely concomitant hyperplasia. Patients usually present in the second or third decade ( Hernández-Ramírez et al . 2015 ) and are less responsive to somatostatin analogues (SSA) ( Daly et al . 2010 ). Germline mutations

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0254
Volume/Issue:
Volume 235: Issue 3
Free access
Astrid C Hauge-Evans Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, 2.27 Henrietta Raphael Building, Guy's Campus, London SE1 1UL, UK

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James Bowe Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, 2.27 Henrietta Raphael Building, Guy's Campus, London SE1 1UL, UK

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Zara J Franklin Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, 2.27 Henrietta Raphael Building, Guy's Campus, London SE1 1UL, UK

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Zoheb Hassan Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, 2.27 Henrietta Raphael Building, Guy's Campus, London SE1 1UL, UK

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Peter M Jones Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, 2.27 Henrietta Raphael Building, Guy's Campus, London SE1 1UL, UK

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Introduction Somatostatin (SST) is synthesised and secreted by neuroendocrine cells in the CNS and in the gastrointestinal and immune systems ( Reichlin 1983 a , b ). In the pancreatic islet, the peptide is produced by δ-cells, which comprise

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0709
Volume/Issue:
Volume 225: Issue 1
Free access
Raúl M Luque Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba, Spain
Hospital Universitario Reina Sofia (HURS), Cordoba, Spain
CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain

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Rhonda D Kineman Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago and Research and Development Division, Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Introduction Neuronostatin (NST), a recently described peptide hormone encoded in the preprosomatostatin gene but without amino-acid homology to somatostatin (SST) ( Samson et al. 2008 ), has been shown to exert important physiological

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0135
Volume/Issue:
Volume 237: Issue 3
Free access
Alejandro Ibáñez-Costa Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Esther Rivero-Cortés Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Mari C Vázquez-Borrego Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Manuel D Gahete Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Luis Jiménez-Reina Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Morphological Sciences, Universidad de Córdoba, Córdoba, Spain

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Eva Venegas-Moreno Metabolism and Nutrition Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain

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Andrés de la Riva Service of Neurosurgery, Hospital Universitario Reina Sofía, Córdoba, Spain

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Miguel Ángel Arráez Neurosurgical Department, Carlos Haya Hospital, Málaga, Spain

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Inmaculada González-Molero Department of Endocrinology and Nutrition, Carlos Haya Hospital, Málaga, Spain

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Herbert A Schmid Novartis Pharma AG, Novartis Institutes for Biomedical Research, Oncology, CH-4057 Basel, Switzerland

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Silvia Maraver-Selfa Service of Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain

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Inmaculada Gavilán-Villarejo Endocrinology and Nutrition Unit, Hospital Universitario Puerta del Mar, Cádiz, Spain

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Juan Antonio García-Arnés Department of Endocrinology and Nutrition, Carlos Haya Hospital, Málaga, Spain

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Miguel A Japón Department of Pathology, Hospital Universitario Virgen del Rocío, Seville, Spain

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Alfonso Soto-Moreno Metabolism and Nutrition Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain

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María A Gálvez Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Service of Endocrinology and Nutrition, Hospital Universitario Reina Sofía, Córdoba, Spain

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Raúl M Luque Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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Justo P Castaño Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
Department of Cell Biology, Physiology and Immunology, Universidad de Córdoba, Córdoba, Spain
Hospital Universitario Reina Sofía, Córdoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Córdoba, Spain

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( Melmed 2011 ). Surgery is the first-line treatment for most pituitary tumors, except for prolactin (PRL)-secreting lactotrope tumors (prolactinomas), which often respond favorably to medical treatment with dopamine agonists. Synthetic somatostatin (SST

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-16-0332
Volume/Issue:
Volume 231: Issue 2
Free access
J Bryce Ortiz Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, Arizona, USA
Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA

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Sebastian Tellez Arizona State University, School of Life Sciences, Tempe, Arizona, USA

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Giri Rampal Department of Child Health, University of Arizona College of Medicine, Phoenix, Arizona, USA
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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Grant S Mannino Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Nicole Couillard Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Matias Mendez Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Tabitha R F Green Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Sean M Murphy Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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Rachel K Rowe Department of Integrative Physiology, University of Colorado, Boulder, Colorado, USA

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development, remains unclear. GH release is regulated by the hypothalamic peptides somatostatin and growth hormone releasing hormone (GHRH). Somatostatin is released from somatostatin-expressing neurons in the periventricular nucleus of the hypothalamus

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0157
Volume/Issue:
Volume 260: Issue 1
Open access
William H T Smith Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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R Unnikrishnan Nair Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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Dawn Adamson Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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Mark T Kearney Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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Stephen G Ball Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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Anthony J Balmforth Integrated Molecular Cardiology Group, University of Leeds, Leeds LS2 9JT, UK
Department of Cardiothoracic Surgery, The General Infirmary at Leeds, Leeds LS1 3EX, UK
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
GKT School of Medicine, London WC2R 2LS, UK

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in acromegaly ( Clayton 2003 ). The coexistence of hypertension increases the incidence of cardiac abnormalities ( Colao et al. 2000 a ) and the risk of premature death ( Holdaway et al. 2004 ). Treatment with the somatostatin receptor

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06082
Volume/Issue:
Volume 187: Issue 3
Free access
Julia N C Toews Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Geoffrey L Hammond Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Victor Viau Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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. During this time, testicular testosterone organizes hypothalamic somatostatin (SST) and growth hormone-releasing hormone (GHRH) neurons that influence the liver later in development, and the hypothalamic-pituitary-thyroid (HPT) axis develops as a result

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0286
Volume/Issue:
Volume 248: Issue 1
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Herbert A Schmid Novartis Pharma AG, Novartis Institutes for Biomedical Research, Oncology, CH-4057 Basel, Switzerland

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Josef Brueggen Novartis Pharma AG, Novartis Institutes for Biomedical Research, Oncology, CH-4057 Basel, Switzerland

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Introduction Somatostatin, an inhibitory hormone widely distributed throughout the central nervous system and peripheral tissues, plays an important regulatory role in neurotransmission and secretion, preventing the release of GH, TSH

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DOI:
https://doi.org/10.1530/JOE-11-0224
Volume/Issue:
Volume 212: Issue 1
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Zheng Zhao
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Ichiro Sakata
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Yusuke Okubo
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Kanako Koike
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Kenji Kangawa Department of Regulation Biology, Department of Biochemistry, Faculty of Science, Saitama University, 255 Shimo-ohkubo, Sakuraku, Saitama 338-8570, Japan

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Takafumi Sakai
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). Somatostatin produced in the gastric mucosa is known to suppress secretion of several gastrointestinal hormones in a paracrine fashion, and many studies have shown that somatostatin and its analogs inhibited ghrelin secretion in both humans and rats ( Barkan

Article Type:
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DOI:
https://doi.org/10.1677/JOE-07-0300
Volume/Issue:
Volume 196: Issue 3
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M Arvigo
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F Gatto
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M Ruscica Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Department of Endocrinology, Department of Human Morphology and Biomedical Sciences ‘Citta' Studi’, Biomeasure Incorporated/IPSEN, Università degli Studi di Genova, 16132 Genova, Italy

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P Ameri
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E Dozio Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Department of Endocrinology, Department of Human Morphology and Biomedical Sciences ‘Citta' Studi’, Biomeasure Incorporated/IPSEN, Università degli Studi di Genova, 16132 Genova, Italy

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M Albertelli
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M D Culler Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Department of Endocrinology, Department of Human Morphology and Biomedical Sciences ‘Citta' Studi’, Biomeasure Incorporated/IPSEN, Università degli Studi di Genova, 16132 Genova, Italy

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M Motta Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Department of Endocrinology, Department of Human Morphology and Biomedical Sciences ‘Citta' Studi’, Biomeasure Incorporated/IPSEN, Università degli Studi di Genova, 16132 Genova, Italy

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F Minuto
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P Magni Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Department of Endocrinology, Department of Human Morphology and Biomedical Sciences ‘Citta' Studi’, Biomeasure Incorporated/IPSEN, Università degli Studi di Genova, 16132 Genova, Italy

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D Ferone
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Introduction Somatostatin (or somatotropin release-inhibiting factor, SRIF) acts through five specific G-protein-coupled membrane receptors (SSTRs), code named sstr 1–5 , expressed in SRIF-target cells ( Patel 1999 , Møller et al . 2003 ). SRIF

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0342
Volume/Issue:
Volume 207: Issue 3
Free access