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transport of docosahexaenoic acid (22:6 n-3, DHA) by GDM ( Herrera & Ortega-Senovilla 2010 , Leveille et al. 2018 ), likely as a consequence of alterations in fatty acids (FA) transport proteins related to phospholipids transfer such as the major
Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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Neuroendocrinologie Moléculaire de la Prise Alimentaire, Neuroendocrinologie Moléculaire de la Prise Alimentaire, Service Nutrition, Lactalis Nutrition Parc d'Activité de Torcé‐secteur Est, University of Paris‐Sud, UMR 8195, F-91405 Orsay, France
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compared a control diet (CD, a soy oil/casein semi-synthetic diet that was equivalent to chow diet) with diets where milk soluble protein (MSP) replaced casein, where a blend of milk fat, rapeseed, and DHA (MRD) replaced soy oil, or a full formula (FF
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Estrogens may affect the essential n-6 and n-3 fatty acids arachidonic acid (AA; C20:4n-6) and docosahexaenoic acid (DHA; C22:6n-3). Therefore, we investigated the long-term effects of hormone replacement therapy and raloxifene, a selective estrogen-receptor modulator, in two randomized, double-blind, placebo-controlled studies. In study I, 95 healthy, non-hysterectomized, early postmenopausal women (age range 47-59 years) received one of the following treatments: daily raloxifene 60 mg (n=24), daily raloxifene 150 mg (n=23), 0.625 mg conjugated equine estrogens (CEE) plus 2.5 mg medroxyprogesterone acetate (MPA; n=24), or placebo (n=24). In study II, 30 men (age range 60-69 years) received daily 120 mg raloxifene (n=15) or placebo (n=15). In study I, plasma cholesteryl ester fatty acids were measured at baseline and after 6, 12, and 24 months in 83 (drop out rate 13%), 73 (23%), and 70 (25%) women respectively. In study II, fatty acids were measured at baseline and after 3 months in 29 men (drop out rate 3%). In postmenopausal women, administration of 150 mg raloxifene increased AA by a mean of +6.1% (P=0.055, not significant). Administration of CEE plus MPA increased AA by +14.1% (P<0.0005). Mean changes in DHA were +22.1% (P=0.003) and +14.9% (P=0.047) respectively, as compared with placebo. In men, 120 mg raloxifene for 3 months did not significantly affect AA (-5.2%; P=0.342) or DHA (+4.0%; P=0.755), but it increased testosterone levels by +19.8% (P=0.006). Administration of raloxifene 150 mg/day as well as CEE plus MPA to postmenopausal women increases the proportion of AA and DHA in plasma cholesteryl esters during a follow-up of 2 years. Short term administration of raloxifene in elderly men did not affect AA or DHA. The synthesis of AA and DHA from precursors may be enhanced through an estrogen receptor-dependent pathway.
Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain
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Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain
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Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain
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Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain
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Department of Cell Biology, Physiology and Immunology, Universitat Autonòma de Barcelona, Bellaterra 08193, Spain
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et al. 1994 a , Ganga et al. 2005 ). In addition, the high content of docosahexaenoic acid (DHA; 22:6n-3) in cellular membranes affects eicosanoid production ( Nablone et al. 1990 ). This fatty acid is also recognised as a precursor of certain
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Introduction It is well-known that n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentanoic acid (EPA, 20:5, n-3) and docosahexanoic acid (DHA, 22:6, n-3), have positive effects in a wide range of health and disease conditions. For
Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
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Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
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Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
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Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
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the fetal zone, which undergoes marked growth and expression of the P450 17α-hydroxylase, 17–20 lyase (P450 C17 ) enzyme catalyzing synthesis of the C 19 -steroids, e.g. dehydroepian-drosterone (DHA) and DHA-sulfate (DHAS), utilized as precursors for
School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK
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School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK
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School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK
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School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK
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School of Biological and Chemical Sciences, University of London, Queen Mary, London E1 4NS, UK
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steroids immediately after birth in the rat, rabbit and guinea pig. Journal of Endocrinology 55 . XXXIV . Hopper B & Yen S 1975 Circulating concentrations of DHA and DHAS during puberty. Journal of Clinical Endocrinology
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-induced K ATP channel inhibition Dihydroxyacetone (DHA) gives FADH2 to complex II of the mitochondrial electron transport system directly through the glycerophosphate shuttle, bypassing the Krebs cycle ( Song et al. 1997 ). To elucidate the
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, Gani & Sylte 2008 ). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain n-3 PUFA found in fish oil (FO), which have an important hypolipidemic effect and act predominantly through the modulation of the transcription of hepatic
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( Hirschmugl et al. 2021 ). Fatty acids could programme an adverse metabolic effect in the offspring ( Kabaran & Besler 2015 ), including the long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) that is reduced in fetuses from diabetic pregnancies
