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Antonio Gázquez, Francisca Rodríguez, María Sánchez-Campillo, Lidia E Martínez-Gascón, Marino B Arnao, Pedro Saura-Garre, María D Albaladejo-Otón, and Elvira Larqué

transport of docosahexaenoic acid (22:6 n-3, DHA) by GDM ( Herrera & Ortega-Senovilla 2010 , Leveille et al. 2018 ), likely as a consequence of alterations in fatty acids (FA) transport proteins related to phospholipids transfer such as the major

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Hassina Ould Hamouda, Bernadette Delplanque, Yacir Benomar, Delphine Crépin, Laure Riffault, Pascale LeRuyet, Cécile Bonhomme, and Mohammed Taouis

compared a control diet (CD, a soy oil/casein semi-synthetic diet that was equivalent to chow diet) with diets where milk soluble protein (MSP) replaced casein, where a blend of milk fat, rapeseed, and DHA (MRD) replaced soy oil, or a full formula (FF

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EJ Giltay, EJ Duschek, MB Katan, PL Zock, SJ Neele, and JC Netelenbos

Estrogens may affect the essential n-6 and n-3 fatty acids arachidonic acid (AA; C20:4n-6) and docosahexaenoic acid (DHA; C22:6n-3). Therefore, we investigated the long-term effects of hormone replacement therapy and raloxifene, a selective estrogen-receptor modulator, in two randomized, double-blind, placebo-controlled studies. In study I, 95 healthy, non-hysterectomized, early postmenopausal women (age range 47-59 years) received one of the following treatments: daily raloxifene 60 mg (n=24), daily raloxifene 150 mg (n=23), 0.625 mg conjugated equine estrogens (CEE) plus 2.5 mg medroxyprogesterone acetate (MPA; n=24), or placebo (n=24). In study II, 30 men (age range 60-69 years) received daily 120 mg raloxifene (n=15) or placebo (n=15). In study I, plasma cholesteryl ester fatty acids were measured at baseline and after 6, 12, and 24 months in 83 (drop out rate 13%), 73 (23%), and 70 (25%) women respectively. In study II, fatty acids were measured at baseline and after 3 months in 29 men (drop out rate 3%). In postmenopausal women, administration of 150 mg raloxifene increased AA by a mean of +6.1% (P=0.055, not significant). Administration of CEE plus MPA increased AA by +14.1% (P<0.0005). Mean changes in DHA were +22.1% (P=0.003) and +14.9% (P=0.047) respectively, as compared with placebo. In men, 120 mg raloxifene for 3 months did not significantly affect AA (-5.2%; P=0.342) or DHA (+4.0%; P=0.755), but it increased testosterone levels by +19.8% (P=0.006). Administration of raloxifene 150 mg/day as well as CEE plus MPA to postmenopausal women increases the proportion of AA and DHA in plasma cholesteryl esters during a follow-up of 2 years. Short term administration of raloxifene in elderly men did not affect AA or DHA. The synthesis of AA and DHA from precursors may be enhanced through an estrogen receptor-dependent pathway.

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R Ganga, L Tort, L Acerete, D Montero, and M S Izquierdo

et al. 1994 a , Ganga et al. 2005 ). In addition, the high content of docosahexaenoic acid (DHA; 22:6n-3) in cellular membranes affects eicosanoid production ( Nablone et al. 1990 ). This fatty acid is also recognised as a precursor of certain

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Xiaofeng Wang and Catherine B Chan

Introduction It is well-known that n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentanoic acid (EPA, 20:5, n-3) and docosahexanoic acid (DHA, 22:6, n-3), have positive effects in a wide range of health and disease conditions. For

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Oliver C Watkins, Mohammed Omedul Islam, Preben Selvam, Reshma Appukuttan Pillai, Amaury Cazenave-Gassiot, Anne K Bendt, Neerja Karnani, Keith M Godfrey, Rohan M Lewis, Markus R Wenk, and Shiao-Yng Chan

previously reported that human term placental explants incubated with stable-isotope-labeled palmitic acid (PA: saturated fatty acid), oleic acid (OA: monounsaturated fatty acid) or docosahexaenoic acid (DHA: long-chain polyunsaturated fatty acid (LC

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Adina Dumitrescu, Graham W Aberdeen, Gerald J Pepe, and Eugene D Albrecht

the fetal zone, which undergoes marked growth and expression of the P450 17α-hydroxylase, 17–20 lyase (P450 C17 ) enzyme catalyzing synthesis of the C 19 -steroids, e.g. dehydroepian-drosterone (DHA) and DHA-sulfate (DHAS), utilized as precursors for

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Duarte Pignatelli, Fang Xiao, Alexandra M Gouveia, Jorge G Ferreira, and Gavin P Vinson

steroids immediately after birth in the rat, rabbit and guinea pig. Journal of Endocrinology 55 . XXXIV . Hopper B & Yen S 1975 Circulating concentrations of DHA and DHAS during puberty. Journal of Clinical Endocrinology

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Y-H Suh, S-Y Kim, H-Y Lee, B C Jang, J H Bae, J-N Sohn, J-H Bae, S-I Suh, J-W Park, K-U Lee, and D-K Song

-induced K ATP channel inhibition Dihydroxyacetone (DHA) gives FADH2 to complex II of the mitochondrial electron transport system directly through the glycerophosphate shuttle, bypassing the Krebs cycle ( Song et al. 1997 ). To elucidate the

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Luana Lopes Souza, Aline Cordeiro, Lorraine Soares Oliveira, Gabriela Silva Monteiro de Paula, Larissa Costa Faustino, Tania Maria Ortiga-Carvalho, Karen Jesus Oliveira, and Carmen Cabanelas Pazos-Moura

, Gani & Sylte 2008 ). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are long-chain n-3 PUFA found in fish oil (FO), which have an important hypolipidemic effect and act predominantly through the modulation of the transcription of hepatic