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Alison Mostyn UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Linda Attig UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Thibaut Larcher UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Samir Dou UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Pascale Chavatte-Palmer UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Monia Boukthir UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Arieh Gertler UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Jean Djiane UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Michael E Symonds UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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Latifa Abdennebi-Najar UP 2012.10.101 EGEAL, School of Veterinary Medicine and Science, INRA UMR 703, INRA, Unité de Recherche 04UR08/03, The Hebrew University of Jerusalem, Unité NOPA, Early Life Research Unit, Institut Polytechnique LaSalle, Beauvais, France

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due to an open reading frame on the BAT-specific uncoupling protein 1 ( UCP1 ) gene in the porcine species meaning that UCP1 is not expressed ( Berg et al . 2006 ). However, it has more recently been suggested that BAT is present in young piglets

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0155
Volume/Issue:
Volume 223: Issue 1
Free access
Stephanie L Clookey Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Rebecca J Welly Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Terese M Zidon Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Michelle L Gastecki Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Makenzie L Woodford Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Zachary I Grunewald Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Nathan C Winn Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Dusti Eaton Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Natalia G Karasseva Transgenic Animal Core, University of Missouri, Columbia, Missouri, USA

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Harold S Sacks Endocrine and Diabetes Division, Veterans Greater Los Angeles Healthcare System, Los Angeles, California, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Child Health, University of Missouri, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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been shown to improve whole-body insulin sensitivity and glucose homeostasis in overweight adult humans ( Chondronikola et al. 2014 ) and rodents ( Stanford et al. 2012 ). Uncoupling protein 1 (UCP1) is the signature mitochondrial protein in BAT

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-18-0139
Volume/Issue:
Volume 239: Issue 2
Free access
K Alexander H Iwen Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Oezge Senyaman Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Arne Schwartz Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Maren Drenckhan Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Britta Meier Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Dirk Hadaschik Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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Johannes Klein Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany

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chemiluminescence kit (Roche Molecular Biochemicals). UCP-1 antibody, β-actin antibody and specific MC receptor antibodies were purchased from Chemicon (Temecula, CA, USA). Phospho-specific and total p38 MAPK antibodies were obtained from Cell Signaling (Beverly, MA

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0299
Volume/Issue:
Volume 196: Issue 3
Free access
ML Bonet
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J Oliver
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C Pico
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F Felipe
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J Ribot
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S Cinti
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A Palou
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The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1660511
Volume/Issue:
Volume 166: Issue 3
Free access
Amy Warner AstraZeneca, Center of Brain, CVMD IMED, Pepparedsleden 1, 43183 Mölndal, Sweden

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Jens Mittag AstraZeneca, Center of Brain, CVMD IMED, Pepparedsleden 1, 43183 Mölndal, Sweden

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2004 ). At the molecular level this process depends on uncoupling protein 1 (UCP1), which shortcuts the proton gradient in mitochondria to produce heat instead of ATP. Several other molecules have been identified to be integral in BAT thermogenesis, the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0408
Volume/Issue:
Volume 228: Issue 1
Free access
Andrea Anedda Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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Eduardo Rial Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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M Mar González-Barroso Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

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UCP1 ( Ledesma et al . 2002 , Krauss et al . 2005 ). UCP1 is present in brown adipose tissue and it is the only member of the family whose physiological function and regulation have been firmly established. UCP1 is a proton transporter activated by

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0278
Volume/Issue:
Volume 199: Issue 1
Free access
S Pearce
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H Budge
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A Mostyn
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E Genever
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R Webb
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P Ingleton
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A M Walker
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M E Symonds
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T Stephenson
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. 1998 ) preceding the rise in the abundance of the brown adipose tissue-specific mitochondrial protein, uncoupling protein (UCP)1 ( Clarke et al. 1997 a ) immediately after birth. Rapid activation of UCP1 in the newborn is critical in preventing

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.05732
Volume/Issue:
Volume 184: Issue 2
Free access
M G Gnanalingham Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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A Mostyn Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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J Wang Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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R Webb Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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D H Keisler Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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N Raver Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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M C Alves-Guerra Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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C Pecqueur Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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B Miroux Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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T Stephenson Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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M E Symonds Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
Department of Animal Sciences, University of Missouri, Columbia, Missouri, USA
Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
Faculté de Médecine Necker-Enfants-Malades, CNRS-UPR 9078, Paris, France

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–pituitary–adrenal axis with respect to the regulation of cortisol production coincident with the rapid activation of uncoupling protein (UCP)-1, which is unique to brown adipose tissue (BAT) ( Clarke et al. 1997 a , Ricquier & Bouillaud 2000 ), and is followed by the

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06251
Volume/Issue:
Volume 187: Issue 1
Free access
John-Paul Fuller-Jackson
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Belinda A Henry Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria, Australia

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perceived by the brain, leading to activation of the sympathetic nervous system (SNS) and the induction of thermogenesis ( Lowell & Spiegelman 2000 , Cannon & Nedergaard 2004 ). Noradrenaline is released within BAT and activates uncoupling protein 1 (UCP1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0090
Volume/Issue:
Volume 237: Issue 3
Free access
Johanna L Barclay School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Hadiya Agada School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Christina Jang School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Micheal Ward School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Neil Wetzig School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Ken K Y Ho School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia

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Introduction Brown adipose tissue (BAT) plays an important role in thermoregulation and energy balance in rodents. Thermogenesis in BAT is achieved by uncoupling protein 1 (UCP1), which dissociates ATP synthesis from the mitochondrial

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0538
Volume/Issue:
Volume 224: Issue 2
Free access