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Hannah J Welters
Hannah J Welters
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Alina Oknianska
Alina Oknianska
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Kai S Erdmann
Kai S Erdmann
Institute of Biomedical and Clinical Science, Department of Biochemistry II, Institut fuer Zellbiologie (Tumorforschung), Peninsula Medical School, Universities of Exeter and Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, UK
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Gerhart U Ryffel
Gerhart U Ryffel
Institute of Biomedical and Clinical Science, Department of Biochemistry II, Institut fuer Zellbiologie (Tumorforschung), Peninsula Medical School, Universities of Exeter and Plymouth, John Bull Building, Research Way, Plymouth PL6 8BU, UK
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Noel G Morgan
Noel G Morgan
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PCR master mix (Rat Wnt Signalling Pathway RT2 Profiler PCR Array; SuperArray cat no. APRN-043A). The PCR was run on a Bio-Rad iCycler, with 1 cycle of 10 min at 95 °C followed by 40 cycles of 15 s at 95 °C and 1 min at 60 °C. Cycle threshold (Ct
T Suwa
T Suwa
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M Chen
M Chen
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CL Hawks
CL Hawks
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PJ Hornsby
PJ Hornsby
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The mechanisms underlying the differentiation of the adrenal cortex into zones are unclear. Microarray studies on RNA from microdissected zona reticularis (ZR) and zona fasciculata/zona glomerulosa (ZF/ZG) derived from adult human adrenal glands showed that a gene of the dickkopf family (DKK), DKK3, is differentially expressed in the zones. The Dickkopf proteins are morphogens involved in Wnt signalling. Northern blotting showed higher DKK3 transcript levels in ZF/ZG than ZR samples. In situ hybridization on adult human adrenal gland sections showed that DKK3 expression was much higher in the ZG than in the ZF or ZR. DKK3 expression was also higher in the medulla. We screened for expression of other members of the DKK family and the related Wingless-type mouse mammary tumor virus integration site gene family (WNT), frizzled (FZD), and dishevelled (DVL) gene families. Among dickkopf family members, only DKK3 was expressed at a detectable level in both human and mouse adrenocortical RNA samples. Consistent with previously published data on the effects of Wnt4 gene disruption in the mouse, we found only WNT4 expression within the WNT family in both human and mouse RNA. Northern blotting showed that WNT4 was expressed at a higher level in ZF/ZG cells than in ZR. The higher level of DKK3 and WNT4 expression in ZF/ZG cells was confirmed by real-time PCR. In the frizzled and dishevelled families we found FZD1, FZD2 and DVL3 transcripts in human adrenocortical RNA, and FZD2 and DVL3 in mouse adrenocortical RNA. These data show that a variety of genes of the Wnt signalling pathways are expressed in the adrenal cortex. The zonal distribution of DKK3 expression suggests that it could be involved in zonal differentiation or growth.
Won Bae Kim
Won Bae Kim
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Christopher J Lewis
Christopher J Lewis
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Kelly D McCall
Kelly D McCall
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Ramiro Malgor
Ramiro Malgor
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Aimee D Kohn
Aimee D Kohn
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Randall T Moon
Randall T Moon
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Leonard D Kohn
Leonard D Kohn
Edison Biotechnology Institute and College of Osteopathic Medicine, Ohio University, The Ridges, Athens, Ohio 45701, USA
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, South Korea
The Howard Hughes Medical Institute and
The Department of Hematology, University of Washington, Seattle, Washington 98195, USA
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). Over the past two decades, the 19 members of the Wnt protein family that have been found in mammals, have all been shown to be cysteine-rich glycoproteins that act as short-range ligands to i) locally activate receptor-mediated signaling pathways in a
Tatiana Dorfman
Tatiana Dorfman
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Yulia Pollak
Yulia Pollak
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Rima Sohotnik
Rima Sohotnik
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Arnold G Coran
Arnold G Coran
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Jacob Bejar
Jacob Bejar
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Igor Sukhotnik
Igor Sukhotnik
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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Laboratory of Intestinal Adaptation and Recovery, Departments of Pediatric Surgery B, Pathology, Section of Pediatric Surgery, The Ruth and Bruce Rappaport Faculty of Medicine, Technion‐Israel Institute of Technology, Haifa, Israel
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-catenin-dependent (canonical) and β-catenin-independent (noncanonical) pathways ( Lu et al . 2004 , Turashvili et al . 2006 ). The canonical Wnt signaling pathway regulates cell fate and proliferation, and this signaling is initiated by the binding of Wnt ligands to
Binbin Guan
Binbin Guan
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
Department of Endocrinology, FuJian Union hospital, Fuzhou, P R China
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Department of Endocrinology, FuJian Union hospital, Fuzhou, P R China
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Wenyi Li
Wenyi Li
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Fengying Li
Fengying Li
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Yun Xie
Yun Xie
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Qicheng Ni
Qicheng Ni
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Yanyun Gu
Yanyun Gu
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Xiaoying Li
Xiaoying Li
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Qidi Wang
Qidi Wang
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Hongli Zhang
Hongli Zhang
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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Guang Ning
Guang Ning
Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P R China
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them from binding to their receptors, thereby inhibiting the activity of the Wnt signaling pathway ( Kawano & Kypta 2003 ). SFRP5 was one of the most extensively studied proteins in adipose tissue ( Ouchi et al . 2010 , Mori et al . 2012 ). Recently
Diego Safian
Diego Safian
Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands
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Jan Bogerd
Jan Bogerd
Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands
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Rüdiger W Schulz
Rüdiger W Schulz
Reproductive Biology Group, Division Developmental Biology, Institute of Biodynamics and Biocomplexity, Department of Biology , Faculty of Science, University of Utrecht, Utrecht, The Netherlands
Reproduction and Developmental Biology Group, Institute of Marine Research, Nordnes, Bergen, Norway
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Reproduction and Developmental Biology Group, Institute of Marine Research, Nordnes, Bergen, Norway
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genes belonging to the Wnt signaling pathway. Similar results were reported for rainbow trout testis tissue ( Sambroni et al. 2013 ). The Wnt signaling system is a conserved cell-to-cell communication system that consists of canonical and non
Virginia Rider
Virginia Rider
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Kazuto Isuzugawa
Kazuto Isuzugawa
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Meryl Twarog
Meryl Twarog
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Stacy Jones
Stacy Jones
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Brent Cameron
Brent Cameron
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Kazuhiko Imakawa
Kazuhiko Imakawa
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Jianwen Fang
Jianwen Fang
Department of Biology, Pittsburg State University, Pittsburg, Kansas 66762, USA
Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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Laboratory of Animal Breeding, Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045, USA
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G1 transit ( Diehl et al. 1998 ). Secondly, GSK-3β is one component of a multimeric complex containing several proteins including axin, adenomatous polyposis coli (APC), and β-catenin. Activation of the wingless (Wnt) signal transduction pathway
Yarikipati Prathibha
Yarikipati Prathibha
Department of Animal Biology, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, Telangana, India
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Balasubramanian Senthilkumaran
Balasubramanian Senthilkumaran
Department of Animal Biology, School of Life Sciences, University of Hyderabad, P.O. Central University, Hyderabad, Telangana, India
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. Conclusion This study demonstrates that pax2 plays an important role in ovarian development and recrudescence of catfish by regulating steroidogenesis either directly or indirectly through Wnt signaling pathway as evident from transient gene
Benoit Cox
Benoit Cox
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Heleen Roose
Heleen Roose
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Annelies Vennekens
Annelies Vennekens
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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Hugo Vankelecom
Hugo Vankelecom
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology, Unit of Stem Cell Research, University of Leuven (KU Leuven), Leuven, Belgium
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putative pituitary stem cell niche, encompassing the stem cells and the stem cell-supporting cells. The NOTCH (green), SHH (red), WNT (purple) and Hippo (blue) pathways are shown in their ‘off’ (left) and ‘on’ status (right). Interaction of the NOTCH
Nicoleta C Olarescu
Nicoleta C Olarescu
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Darlene E Berryman
Darlene E Berryman
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Lara A Householder
Lara A Householder
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Ellen R Lubbers
Ellen R Lubbers
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Edward O List
Edward O List
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Fabian Benencia
Fabian Benencia
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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John J Kopchick
John J Kopchick
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Jens Bollerslev
Jens Bollerslev
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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Section of Specialized Endocrinology, Faculty of Medicine, Edison Biotechnology Institute, Heritage College of Osteopathic Medicine, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, PO Box 4950, N‐0424 Oslo, Norway
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differentiation of MSCs are regulated in part by the Wnt/β-catenin signaling pathway. That is, activation of Wnt/β-catenin signaling decreases the adipogenic potential of MSCs ( Ross et al . 2000 , Lowe et al . 2011 ). Although MSCs have primarily been
