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concentration with muscle mass and strength and an inverse relationship with fat mass ( Bhasin et al. 2001 , Finkelstein et al. 2013 ). Testosterone treatment decreases fat mass and increases lean body mass (skeletal muscle and bone) and muscle strength in
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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are produced by a number of tissues in addition to the gonads, including the kidney ( Meunier et al. 1988 ), bone ( Broxmeyer et al. 1988 ), lungs, liver, heart ( Chen & Johnson 1996 ), adipose tissue ( Sjöholm et al. 2006 ), breast ( Di Loreto
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conditions. Impaired bone health has been associated with T2DM, and a recent study by Lasschuit and colleagues demonstrated that people with type 2 diabetes with DPN had poorer bone health measured by quantitative calcaneal ultrasound, than people with T2DM
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Kidney GFR, ECW, and vascular volume Bone Growth and turnover Liver Growth factors and substrate metabolism Fat Lipid utilisation Skin Exocrine function and hair growth Brain Neurogenesis ECW
Department of Medicine, Monash University, Clayton, Victoria, Australia
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.27291 ) Loh HH & Sukor N 2020 Associations between primary aldosteronism and diabetes, poor bone health, and sleep apnea-what do we know so far? Journal of Human Hypertension 34 5 – 15 . ( https://doi.org/10.1038/s41371-019-0294-8 ) Lottspeich C
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
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St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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hyperactivity on bone fibrous dysplasia in McCune-Albright syndrome . Clinical Endocrinology 89 56 – 64 . ( https://doi.org/10.1111/cen.13722 ) Trivellin G Daly AF Faucz FR Yuan B Rostomyan L Larco DO Schernthaner-Reiter MH Szarek E Leal LF
