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100 YEARS OF INSULIN: Arresting or curing type 1 diabetes: an elusive goal, but closing the gap

Pieter-Jan Martens

Pieter-Jan Martens Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Conny Gysemans

Conny Gysemans Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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Chantal Mathieu

Chantal Mathieu Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

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and peptide fragments were targeted by the immune system ( Bonifacio 2015 ). Another strong argument that the immune system may be the causing factor in T1D came from the early observation that transplantation of non-T cell-depleted bone marrow

Article Type:: Review Article

Collections:: 100 years of insulin: A special collection

DOI:: https://doi.org/10.1530/JOE-20-0552

Volume/Issue:: Volume 249: Issue 2

Free access

100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story

Sarah J Richardson

Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

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Alberto Pugliese

Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

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.coph.2018.07.006 ) Richardson SJ Willcox A Bone AJ Foulis AK Morgan NG 2009 The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes . Diabetologia 52 1143 – 1151 . ( https://doi.org/10.1007/s

Article Type:: Review Article

Collections:: 100 years of insulin: A special collection, Top-cited articles of 2023

DOI:: https://doi.org/10.1530/JOE-21-0358

Volume/Issue:: Volume 252: Issue 2

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Beta-cell function and human islet transplantation: can we improve?

Jennifer Chen

Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton

Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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transplants will vary between patients. Other alternate engraftment sites being evaluated in preclinical models and early clinical trials include muscle, bone marrow, and omentum ( Christoffersson et al. 2010 , Stokes et al. 2017 , Stice et al. 2018