Filter

Refine by date

—

Refine by collections

Refine by access

  • Print
  • Save

Search Results

You are looking at 1 - 10 of 148 items for :

  • bone marrow adipose tissue x
  • Refine by access: Content accessible to me x
Clear All
Andrea Lovdel University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Andrea Lovdel in
Google Scholar
PubMed Close
,
Karla J Suchacki University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Karla J Suchacki in
Google Scholar
PubMed Close
,
Fiona Roberts University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Fiona Roberts in
Google Scholar
PubMed Close
,
Richard J Sulston University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Richard J Sulston in
Google Scholar
PubMed Close
,
Robert J Wallace Department of Orthopaedics, The University of Edinburgh, Edinburgh, UK

Search for other papers by Robert J Wallace in
Google Scholar
PubMed Close
,
Benjamin J Thomas University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Benjamin J Thomas in
Google Scholar
PubMed Close
,
Rachel M B Bell University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Rachel M B Bell in
Google Scholar
PubMed Close
,
Iris Pruñonosa Cervera University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Iris Pruñonosa Cervera in
Google Scholar
PubMed Close
,
Gavin J Macpherson Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK

Search for other papers by Gavin J Macpherson in
Google Scholar
PubMed Close
,
Nicholas M Morton University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK
Centre for Systems Health and Integrated Metabolic Research, Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK

Search for other papers by Nicholas M Morton in
Google Scholar
PubMed Close
,
Natalie Z M Homer University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Natalie Z M Homer in
Google Scholar
PubMed Close
,
Karen E Chapman University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by Karen E Chapman in
Google Scholar
PubMed Close
, and
William P Cawthorn University/BHF Centre for Cardiovascular Science, The University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK

Search for other papers by William P Cawthorn in
Google Scholar
PubMed Close

Introduction Bone marrow adipocytes comprise up to 70% of total bone marrow (BM) volume and over 10% of total adipose mass in healthy adult humans, collectively forming an integrated tissue referred to as bone marrow adipose tissue (BMAT

Article Type:
Research Article
Collections:
Sex effects collection
DOI:
https://doi.org/10.1530/JOE-24-0072
Volume/Issue:
Volume 262: Issue 2
Open access
M J Devlin Department of Anthropology, University of Michigan, Ann Arbor, Michigan, USA

Search for other papers by M J Devlin in
Google Scholar
PubMed Close
,
D J Brooks Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Search for other papers by D J Brooks in
Google Scholar
PubMed Close
,
C Conlon Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Search for other papers by C Conlon in
Google Scholar
PubMed Close
,
M van Vliet Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Search for other papers by M van Vliet in
Google Scholar
PubMed Close
,
L Louis Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

Search for other papers by L Louis in
Google Scholar
PubMed Close
,
C J Rosen Maine Medical Center Research Institute, Scarborough, Maine, USA

Search for other papers by C J Rosen in
Google Scholar
PubMed Close
, and
M L Bouxsein Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA

Search for other papers by M L Bouxsein in
Google Scholar
PubMed Close

Introduction Bone marrow adipose tissue (MAT) is a complex and dynamic depot that likely includes both constitutive and regulated cell populations ( Devlin & Rosen 2015 , Scheller et al . 2015 ). MAT accumulation is a normal component of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0473
Volume/Issue:
Volume 229: Issue 3
Free access
Karla J Suchacki The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

Search for other papers by Karla J Suchacki in
Google Scholar
PubMed Close
,
Fiona Roberts The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

Search for other papers by Fiona Roberts in
Google Scholar
PubMed Close
,
Andrea Lovdel The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

Search for other papers by Andrea Lovdel in
Google Scholar
PubMed Close
,
Colin Farquharson The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

Search for other papers by Colin Farquharson in
Google Scholar
PubMed Close
,
Nik M Morton The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

Search for other papers by Nik M Morton in
Google Scholar
PubMed Close
,
Vicky E MacRae The Roslin Institute, The University of Edinburgh, Easter Bush, Midltohian

Search for other papers by Vicky E MacRae in
Google Scholar
PubMed Close
, and
William P Cawthorn The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

Search for other papers by William P Cawthorn in
Google Scholar
PubMed Close

bones involves its integral role in the endocrine control of whole-body energy metabolism ( Guntur & Rosen 2013 ). One example of the poorly understood metabolic functions of the skeleton is the presence of adipose tissue within the bone marrow

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0147
Volume/Issue:
Volume 234: Issue 1
Free access
Russell T Turner Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Russell T Turner in
Google Scholar
PubMed Close
,
Kenneth A Philbrick Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Kenneth A Philbrick in
Google Scholar
PubMed Close
,
Carmen P Wong Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Carmen P Wong in
Google Scholar
PubMed Close
,
Dawn A Olson Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Dawn A Olson in
Google Scholar
PubMed Close
,
Adam J Branscum Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Adam J Branscum in
Google Scholar
PubMed Close
, and
Urszula T Iwaniec Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences
Skeletal Biology Laboratory, Center for Healthy Aging Research, Biostatistics, School of Biological and Population Health Sciences

Search for other papers by Urszula T Iwaniec in
Google Scholar
PubMed Close

proteoglycans and glycosaminoglycans with toluidine blue was used to identify the cartilage within trabeculae. Adipocyte number and area were also measured and expressed as bone marrow adiposity (tissue area occupied by adipocytes: adipocyte area/tissue area

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0224
Volume/Issue:
Volume 223: Issue 1
Free access
Patricia K Russell Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Patricia K Russell in
Google Scholar
PubMed Close
,
Salvatore Mangiafico Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Salvatore Mangiafico in
Google Scholar
PubMed Close
,
Barbara C Fam Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Barbara C Fam in
Google Scholar
PubMed Close
,
Michele V Clarke Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Michele V Clarke in
Google Scholar
PubMed Close
,
Evelyn S Marin Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Evelyn S Marin in
Google Scholar
PubMed Close
,
Sofianos Andrikopoulos Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Sofianos Andrikopoulos in
Google Scholar
PubMed Close
,
Kristine M Wiren Research Service, Veterans Affairs Medical Center, Portland, Oregon, USA
Departments of Medicine and Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA

Search for other papers by Kristine M Wiren in
Google Scholar
PubMed Close
,
Jeffrey D Zajac Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Jeffrey D Zajac in
Google Scholar
PubMed Close
, and
Rachel A Davey Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia

Search for other papers by Rachel A Davey in
Google Scholar
PubMed Close

hypogonadal patients as compared to the other fat depots, bone marrow adipose tissue (BMAT) is significantly associated with skeletal health. Although studies on the function of BMAT is limited, it is clear that increased BMAT is associated with decreased bone

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0656
Volume/Issue:
Volume 237: Issue 1
Free access
Russell T Turner Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA

Search for other papers by Russell T Turner in
Google Scholar
PubMed Close
,
Kenneth A Philbrick Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

Search for other papers by Kenneth A Philbrick in
Google Scholar
PubMed Close
,
Amida F Kuah Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

Search for other papers by Amida F Kuah in
Google Scholar
PubMed Close
,
Adam J Branscum Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA

Search for other papers by Adam J Branscum in
Google Scholar
PubMed Close
, and
Urszula T Iwaniec Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA

Search for other papers by Urszula T Iwaniec in
Google Scholar
PubMed Close

et al . 2013 ). The lower bone formation generally reported in these mice is primarily due to reduced osteoblast number, although reduced osteoblast activity has also been noted. The dramatic increase in bone marrow adipose tissue (MAT) in long bones

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0103
Volume/Issue:
Volume 233: Issue 3
Free access
Monisha Rajasekaran Department of Biological Sciences, University of Ulsan, Ulsan, Korea

Search for other papers by Monisha Rajasekaran in
Google Scholar
PubMed Close
,
Ok-Joo Sul Department of Biological Sciences, University of Ulsan, Ulsan, Korea

Search for other papers by Ok-Joo Sul in
Google Scholar
PubMed Close
,
Eun-Kyung Choi Department of Biological Sciences, University of Ulsan, Ulsan, Korea

Search for other papers by Eun-Kyung Choi in
Google Scholar
PubMed Close
,
Ji-Eun Kim Department of Biological Sciences, University of Ulsan, Ulsan, Korea

Search for other papers by Ji-Eun Kim in
Google Scholar
PubMed Close
,
Jae-Hee Suh Department of Pathology, Ulsan University Hospital, Ulsan, Korea

Search for other papers by Jae-Hee Suh in
Google Scholar
PubMed Close
, and
Hye-Seon Choi Department of Biological Sciences, University of Ulsan, Ulsan, Korea

Search for other papers by Hye-Seon Choi in
Google Scholar
PubMed Close

of adherent soft tissue. The bone ends were cut, and the marrow cavity was flushed with α-MEM from one end of the bone using a sterile 21-gauge needle. The bone marrow was further agitated using a Pasteur pipette in order to obtain a single

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0190
Volume/Issue:
Volume 242: Issue 2
Free access
Corine Martineau
Search for other papers by Corine Martineau in
Google Scholar
PubMed Close
,
Louise Martin-Falstrault Laboratoire du Métabolisme Osseux, Laboratoire du Métabolisme des Lipoprotéines, BioMed, Département des Sciences Biologiques Université du Québec à Montréal, Case Postale 8888, Succursale Centre-ville, Montréal, Quebec, Canada H3C 3P8

Search for other papers by Louise Martin-Falstrault in
Google Scholar
PubMed Close
,
Louise Brissette Laboratoire du Métabolisme Osseux, Laboratoire du Métabolisme des Lipoprotéines, BioMed, Département des Sciences Biologiques Université du Québec à Montréal, Case Postale 8888, Succursale Centre-ville, Montréal, Quebec, Canada H3C 3P8

Search for other papers by Louise Brissette in
Google Scholar
PubMed Close
, and
Robert Moreau
Search for other papers by Robert Moreau in
Google Scholar
PubMed Close

and reduced Sost gene expression, indicating that ACTH may contribute to the high bone mass phenotype of null mice. In contrast, high plasma leptin levels and enhanced Lep gene expression in adipose tissue were seen in null females only. Moreover

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0147
Volume/Issue:
Volume 222: Issue 2
Free access
Sun-O Ka Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

Search for other papers by Sun-O Ka in
Google Scholar
PubMed Close
,
Mi-Young Song Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

Search for other papers by Mi-Young Song in
Google Scholar
PubMed Close
,
Eun Ju Bae Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

Search for other papers by Eun Ju Bae in
Google Scholar
PubMed Close
, and
Byung-Hyun Park Department of Biochemistry, College of Pharmacy, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 561-756, Republic of Korea

Search for other papers by Byung-Hyun Park in
Google Scholar
PubMed Close

release from stimulated macrophages ( Yoshizaki et al . 2010 , Zhang et al . 2010 ). Myeloid-cell-specific deletion of Sirt1 increases macrophage infiltration into the liver and adipose tissues, as well as production of proinflammatory cytokines, and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0527
Volume/Issue:
Volume 224: Issue 2
Free access
Dario A Gutierrez Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

Search for other papers by Dario A Gutierrez in
Google Scholar
PubMed Close
and
Alyssa H Hasty Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 702 Light Hall, Nashville, Tennessee 37232-0615, USA

Search for other papers by Alyssa H Hasty in
Google Scholar
PubMed Close

Introduction Accumulation of inflammatory macrophages in adipose tissue (AT) during obesity has been shown to correlate with AT inflammation and subsequent insulin resistance (IR; Weisberg et al . 2003 , Xu et al . 2003 ). In addition, the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0338
Volume/Issue:
Volume 212: Issue 3
Free access