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Jennifer M Ikle Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA

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Anna L Gloyn Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Stanford Diabetes Research Center, Stanford University, Stanford, California, USA

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Introduction It was in the 1930s, after the discovery and first use of insulin, that Harold Percival Himsworth first made the distinction between type 1 and type 2 diabetes ( Bryder & Harper 2013 ). However, it was not until the 1970s

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100 years of insulin: A special collection
DOI:
https://doi.org/10.1530/JOE-21-0067
Volume/Issue:
Volume 250: Issue 3
Free access
Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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because of their causal association with diabetes mellitus. For this reason, α cell research has been somewhat neglected, leaving many unanswered questions about α cell biology. However, in recent years, α cell research has gained momentum due to the

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Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0297
Volume/Issue:
Volume 258: Issue 2
Free access
J Cantley School of Medicine, University of Dundee, Dundee, United Kingdom of Great Britain and Northern Ireland

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D L Eizirik ULB Center for Diabetes Research, Université Libre de Bruxelles Faculté de Médecine, Bruxelles, Belgium

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E Latres JDRF International, New York, NY, USA

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C M Dayan Cardiff University School of Medicine, Cardiff, United Kingdom of Great Britain and Northern Ireland

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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022
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the JDRF-DiabetesUK-INNODIA-nPOD Stockholm Symposium 2022

Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease with a strong inflammatory component that results from the interaction between predisposing genes and environmental factors (e.g. viral infections and diet). This interaction

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0082
Volume/Issue:
Volume 259: Issue 1
Open access
Ryan A Lafferty Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Victor A Gault Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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modulation ( Fig. 1 ), it is clear that this signalling pathway holds theoretical promise for the treatment of both type 2 diabetes mellitus (T2DM) and obesity, as has been witnessed to profound effect with GLP-1 ( Nauck et al. 2021 a ). This is especially

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0339
Volume/Issue:
Volume 262: Issue 2
Open access
Karsten Suhre Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar
Department of Physiology and Biophysics, Institute of Bioinformatics and Systems Biology, Qatar Foundation – Education City, Weill Cornell Medical College – Qatar, PO Box 24144, Doha, Qatar

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body, as they are revealed by studies of metabolic profiling in diabetes ( German et al . 2005 , Wenk 2005 ). Application of metabolomics approaches to metabolic disorders, especially diabetes, is particularly promising since deregulations of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0024
Volume/Issue:
Volume 221: Issue 3
Free access
James E Bowe Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Zara J Franklin Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Astrid C Hauge-Evans Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Aileen J King Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Shanta J Persaud Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Peter M Jones Diabetes Research Group, Division of Diabetes and Nutritional Sciences, King's College London, Guy's Campus, London SE1 1UL, UK

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Introduction The incidence of diabetes mellitus, particularly obesity-related type 2 diabetes, is increasing at an alarming rate in the developed world, and this epidemic is driving numerous research programmes into the causes of, and new treatment

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0182
Volume/Issue:
Volume 222: Issue 3
Free access
Elizabeth S Barrie The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Mels Lodder The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Paul H Weinreb The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Jill Buss The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Amer Rajab The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Christopher Adin The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Qing-Sheng Mi The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Gregg A Hadley The Ohio State University Wexner Medical Center, Biogen Idec, College of Veterinary Medicine, Henry Ford Hospital, Room 216 Tzagournis Medical Research Facility, 420 W 12th Avenue, Columbus, Ohio 43201, USA

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Introduction Type 1 diabetes is a T cell-mediated autoimmune disease caused by the destruction of insulin-producing β cells of the islets of Langerhans in the pancreas, resulting in a hyperglycemic state. Non-obese diabetic (NOD) mice (NOD

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0396
Volume/Issue:
Volume 224: Issue 3
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Haiyong Chen Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Hui-Yao Lan Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Dimitrios H Roukos Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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William C Cho Li Ka Sing Faculty of Medicine, Department of Medicine and Therapeutics, Centre for Biosystems and Genome Network Medicine, Department of Clinical Oncology, School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong

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Introduction Diabetes mellitus (DM) affects 347 million people worldwide. The World Health Organization predicts that diabetes-related deaths could double between 2005 and 2030. The research conducted by American Diabetes Association estimated that

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0544
Volume/Issue:
Volume 222: Issue 1
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Emma Ahlqvist Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden

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Rashmi B Prasad Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Leif Groop Department of Clinical Sciences, Malmö , Lund University, Malmö, Sweden
Institute for Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland

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Heterogeneity of diabetes Present official classification of diabetes Diabetes, particularly type 2 diabetes (T2D), is one of the fastest increasing diseases worldwide. However, under the term T2D, we lump together diseases with varying

Article Type:
Review Article
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100 years of insulin: A special collection
DOI:
https://doi.org/10.1530/JOE-20-0596
Volume/Issue:
Volume 252: Issue 3
Free access
Renata Risi Department of Experimental Medicine, Sapienza University of Rome, Sapienza University of Rome, Rome, Italy
University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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Antonio Vidal-Puig University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK
Cambridge University Nanjing Centre of Technology and Innovation, Nanjing, P. R. China
Centro de Investigacion Principe Felipe, Valencia, Spain

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Guillaume Bidault University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK

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associated with a subsequent rise in the incidence of diabetes ( GBD 2021 Diabetes Collaborators 2023 ), making obesity a widely recognised risk factor for the development of type 2 diabetes mellitus (T2D) ( Klein et al. 2022 ). Additionally, emerging

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0313
Volume/Issue:
Volume 262: Issue 1
Open access