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Instituto de Biología y Medicina Experimental, Department of Medicine, Department of Cell Biology, Consejo Nacional de Investigaciones Científicas y Técnicas, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
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, to restore gonadal function, to reduce tumor size, and to preserve or improve residual pituitary function. Prolactin secretion in the normal pituitary is tonically inhibited by hypothalamic dopamine through dopamine D2 receptors (Drd2) expressed on
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cerebral cortex and nucleus accumbens (NAc) ( Phillips et al. 2007 ). Recent studies have shown that mesolimbic dopamine neurons in the ventral tegmental area (VTA) that project to the NAc represent a critical site for ghrelin to trigger food consumption
Department of Pathobiology, College of Veterinary Medicine, Tuskegee University, Tuskegee, Alabama, USA
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Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
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Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA
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reach middle age. During this time, serum estradiol levels are moderately elevated for a period of 6 months. This results in a gradual decline in hypothalamic dopamine levels with a concurrent increase in serum prolactin levels. This chronic
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, our laboratory demonstrated a seasonal modulation of the combined suppressive effects of PRL and dopamine on the gonadotrophin response to GnRH ( Gregory et al . 2004 ). An immortalised gonadotroph cell line, αT 3 -1, has been shown to express D 2
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heterodimerize with other G-protein-coupled receptors, such as the μ-opioid receptor ( Pfeiffer et al . 2002 ) and dopamine (DA) type 2 receptor (D 2 R; Rocheville et al . 2000 b , Baragli et al . 2007 ). The heterodimerization of these G
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Department of Medicine, Barnard College, Department of Surgery of Columbia University Medical Center, Department of Surgery, Institute of Genetics and Biophysics ‘Adriano Buzzati-Traverso’, Naomi Berrie Diabetes Center, Department of Medicine, BB 20-06, Columbia University Medical Center, 650 West 168th Street, New York, New York 10032, USA
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Department of Medicine, Barnard College, Department of Surgery of Columbia University Medical Center, Department of Surgery, Institute of Genetics and Biophysics ‘Adriano Buzzati-Traverso’, Naomi Berrie Diabetes Center, Department of Medicine, BB 20-06, Columbia University Medical Center, 650 West 168th Street, New York, New York 10032, USA
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2000 ). β-Cells of the endocrine pancreas also express dopamine receptors (D2) and respond to exogenous dopamine with inhibited glucose-stimulated insulin secretion ( Ahren & Lundquist 1985 , Niswender et al . 2005 , Rubi et al . 2005 , Shankar et
Centre for Neuroendocrinology and Department of Anatomy, Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, PO Box 913, Dunedin 9054, New Zealand
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catecholamine neurotransmitter, dopamine, rather than the more typical peptide hypothalamic hormones involved in regulating all other pituitary systems. Prolactin is also the only anterior pituitary hormone that does not have an endocrine target tissue, and
Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China
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Neuroscience Research Center, Hebei Medical University, Shijiazhuang, People’s Republic of China
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Department of Human Anatomy, Hebei Medical University, Shijiazhuang, People’s Republic of China
Neuroscience Research Center, Hebei Medical University, Shijiazhuang, People’s Republic of China
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neurotransmissions. An imbalance in dopamine (DA) neurotransmissions leads to either hyperactive or hypoactive neuropsychiatric disorders ( Mehler-Wex et al . 2006 , Howes & Kapur 2009 , Leckman et al . 2010 , Chen et al . 2013 ). Elevation of DA, as a driver
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and University of Buenos Aires, V. Obligado 2490, 1428 Buenos Aires, Argentina
UVA Health System Charlottesville, Virginia, USA
Lawson Health Research Institute, London, Ontario, Canada
Center for the Study of Weight Regulation, Oregon Health & Science University, Portland, Oregon, USA
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Introduction The dopamine D2 receptor (D2R) is the predominant dopamine-receptor subtype in the anterior pituitary and mediates dopamine’s inhibitory actions on lactotropes ( Missale et al. 1998 , Ben-Jonathan & Hnasko 2001
Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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Radboud University Nijmegen Medical Centre, Department of Neurology, Laboratory of Pediatrics and Neurology, Nijmegen, The Netherlands
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Department of Endocrinology, Andrology Unit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
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metabolizing these steroids ( Puy et al. 1995 , Poletti & Martini 1999 , Stoffel-Wagner 2003 , Altman 2004 ). Dopamine is synthesized from tyrosine by dopaminergic neurons, and is also the precursor to norepinephrine in noradrenergic nerves. Dopamine is