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Beta-cell function and human islet transplantation: can we improve?

Jennifer Chen

Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton

Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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and endothelium that is damaged during enzymatic dissociation of islets. Mesenchymal stem cells (MSC), implicated in tissue repair and maintenance of cellular homeostasis, secrete factors with anti-inflammatory, proangiogenic and regenerative