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The alternate pathway of androgen metabolism and window of sensitivity

Marilyn B Renfree

Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw

Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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fetal testis and non-gonadal tissues has been reinforced. Measuring plasma and tissue levels of steroids implicated in both pathways shows that placental progesterone and several other tissues including the liver and adrenal act as a substrate to produce

Article Type:: Review Article

Collections:: Endocrine Society of Australia special collection

DOI:: https://doi.org/10.1530/JOE-22-0296

Volume/Issue:: Volume 258: Issue 3

Free access

Impact of ACE2 on the susceptibility and vulnerability to COVID-19

Kirsty G Pringle

Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp

Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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may be driven by the high levels of oestrogen and progesterone from early in gestation ( Schock et al. 2016 ), which could regulate ACE2 levels. Ang-(1–7) levels are also increased in pregnant compared with non-pregnant women ( Merrill et al. 2002