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Tianru Jin Departments of Medicine, Division of Cell and Molecular Biology, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Departments of Medicine, Division of Cell and Molecular Biology, Physiology, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

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intestinal cell lines ( Jin & Drucker 1995 ). *In pancreatic α-cells but not intestinal L cell, insulin represses gcg expression via the G3 element. (B) DNA sequence of the first 300 bp 5′ flanking region of the rat gcg gene. G1 and four enhancer elements are

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0085
Volume/Issue:
Volume 198: Issue 1
Free access
Nancy H Nabilsi
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Russell R Broaddus Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Adrienne S McCampbell Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Karen H Lu Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Henry T Lynch Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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Lee-may Chen Department of Integrative Biology and Pharmacology, Pathology, Gynecologic Oncology, Department of Preventive Medicine and Public Health, Department of Gynecologic Oncology, University of Texas Health Science Center Houston, 6431 Fannin Street, MSB 5.132A, Houston, Texas 77030, USA Departments of

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David S Loose
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gene expression is distinct from the other IAPs. Survivin is highly expressed during embryonic and fetal development and is overexpressed in virtually all tumor types ( Ambrosini et al . 1997 , Li & Altieri 1999 , O'Driscoll et al . 2003 ) including

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0128
Volume/Issue:
Volume 207: Issue 2
Free access
Wenxia He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiangyan Dai Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Xiaowen Chen Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China
Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Jiangyan He Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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Zhan Yin Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Donghu South Road, Wuhan, Hubei 430072, People's Republic of China

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expression profiling studies have been carried out using different organs or tissues, but very few studies have addressed questions on the developmental changes in pituitary gene expression due to maturation and somatic growth processing in zebrafish

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0488
Volume/Issue:
Volume 221: Issue 3
Free access
Yi Zhao Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Tao Liu Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Nina Zhang Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Fenghua Yi Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Qinghua Wang Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Ivan George Fantus Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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Tianru Jin Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, University of Toronto, Ontario, Canada
Departments of Physiology,
Medicine and
Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Banting and Best Diabetes Center, Faculty of Medicine, University of Toronto, Ontario, Canada

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expression of both insulin and somatostatin genes ( Leonard et al. 1993 , Ohlsson et al. 1993 , Miller et al. 1994 , Lu et al. 1996 ). Pax-6 is probably involved in regulating the expression of genes that encode insulin, glucagon and somatostatin

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06152
Volume/Issue:
Volume 186: Issue 1
Free access
Shanqi Fu Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Miho Kuwahara Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yoko Uchida Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Sei Kondo Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Daichi Hayashi Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yuji Shimomura Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Asami Takagaki Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takashi Nishida Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Yusuke Maruyama Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Mika Ikegame Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Atsuhiko Hattori Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba, Japan

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Satoshi Kubota Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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Takako Hattori Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

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rhythm that persisted for several months in both articular and growth plate cartilage ( Okubo et al. 2013 ). Recently, several studies have demonstrated the rhythmic expression of clock genes in cartilage, indicating that, similar to the central SCN

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0022
Volume/Issue:
Volume 241: Issue 2
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Xiong Weng Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK

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Hao Jiang Gene Expression and Regulation, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

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David J Walker Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK

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Houjiang Zhou MRC Protein Phosphorylation Unit, School of Life Sciences, Dundee, Scotland, UK

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De Lin Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

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Jing Wang Science for Life Laboratory, Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden

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Li Kang Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, Dundee, Scotland, UK

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pathogenesis of T2D by a gene expression-based genome-wide association study ( Kodama et al . 2012 ). Ablation of CD44 by genetic deletion or anti-CD44 monoclonal antibody administration reduced adipose tissue immune cell infiltration and insulin resistance in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-24-0079
Volume/Issue:
Volume 262: Issue 1
Open access
Cesidio Giuliani
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Ines Bucci
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Valeria Montani
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Dinah S Singer Unit of Endocrinology, Experimental Immunology Branch, Department of Biomedical Sciences, Department of Medicine and Sciences of Aging, University ‘G. D'Annunzio’ and Aging Research Center (Ce.S.I.), ‘Gabriele D'Annunzio’ University Foundation, via Colle dell'Ara, Chieti-Pescara, 66013 Chieti, Italy

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Fabrizio Monaco
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Leonard D Kohn Unit of Endocrinology, Experimental Immunology Branch, Department of Biomedical Sciences, Department of Medicine and Sciences of Aging, University ‘G. D'Annunzio’ and Aging Research Center (Ce.S.I.), ‘Gabriele D'Annunzio’ University Foundation, via Colle dell'Ara, Chieti-Pescara, 66013 Chieti, Italy

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Giorgio Napolitano
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. 1999 ). Down-regulation or the absence of MHC class-I gene expression is also considered a hallmark of tissue immune privilege ( Ito et al . 2004 , 2008 ). The involvement of aberrant MHC class-II gene expression in the development of autoimmune

Article Type:
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DOI:
https://doi.org/10.1677/JOE-09-0172
Volume/Issue:
Volume 204: Issue 1
Free access
Guoyue Yuan State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Xia Chen State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Qinyun Ma State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Jie Qiao State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Rongying Li State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Xuesong Li State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Shengxian Li State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Jinfeng Tang State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Libin Zhou State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Huaidong Song State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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Mingdao Chen State Key Laboratory of Medical Genomics, Shanghai Institute of Endocrine and Metabolic Diseases, Center of Molecular Medicine, Ruijin Hospital, Shanghai Jiaotong University Medical School, 197, Ruijin Road II, Shanghai 200025, China
Department of Endocrinology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
Department of Endocrinology, Renji Hospital, 1630, Dongfang Road, Pudong, Shanghai 210127, China

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level is a cause or an effect of insulin resistance and decreased adiponectin. In the current study, we therefore examined the effect of CRP on adiponectin gene expression and secretion in 3T3-L1 adipocytes in vitro . We demonstrated that CRP

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0133
Volume/Issue:
Volume 194: Issue 2
Free access
Sharon E Mitchell Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Ruben Nogueiras Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Kellie Rance Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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D Vernon Rayner Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Sharon Wood Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Carlos Dieguez Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Lynda M Williams Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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/C and Wistar rats, we have compared the levels of circulating hormones and the gene expression of hypothalamic peptides and receptors important in energy balance in these sub-species. These include: Ob-R (all forms of the leptin receptor), GHS-R, AgRP

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06576
Volume/Issue:
Volume 190: Issue 3
Free access
Bohan Wang Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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I Stuart Wood Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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Paul Trayhurn Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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, Trayhurn & Beattie 2001 ). Leptin is a hypoxia-sensitive gene; its expression being stimulated in adipocytes by low O 2 tension ( Grosfeld et al . 2002 b , Lolmède et al . 2003 , Polotsky et al . 2003 , Hausman & Richardson 2004 ), through

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0156
Volume/Issue:
Volume 198: Issue 1
Free access