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the first demonstration of androgen imprinting in which exposure to the hormone during a short window of sensitivity caused later sexual differentiation events ( Fig. 5 ). We followed up by investigating the expression of the genes responsible for
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Academy for Medical Education, Faculty of Medicine, the University of Queensland, Brisbane, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Scaffold protein with multiple functions, including regulation of p27 expression and DNA replication and repair Inactivating mutations distributed throughout the gene Mostly frameshift, nonsense and missense mutations, less commonly splice site mutations
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia
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) showed a biphasic age-driven distribution of Ace2 in murine lungs and trachea across three different gene expression datasets ( Inde et al. 2021 ). First, there was a subtle biphasic distribution in two of the three datasets where lung and tracheal
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Department of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Australia
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.1101/gad.8.4.414 ) 8125256 Voutilainen R Eramaa M & Ritvos O 1991 Hormonally regulated inhibin gene expression in human fetal and adult adrenals . Journal of Clinical Endocrinology and Metabolism 73 1026 – 1030 . ( https://doi.org/10.1210/jcem-73
Department of Medicine, Monash University, Clayton, Victoria, Australia
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ENaC and, as a consequence, slows ENaC degradation ( Snyder et al. 2002 ). Regulation of ENaCα-subunit gene expression involves sgk-1 through relief of Dotla-Af9-mediated transcriptional repression ( Zhang et al. 2007 ). Nedd4-2 is also regulated by
Department of Physiology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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Prostate Cancer Research Program, Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Cabrini Institute, Cabrini Health, Malvern, Victoria, Australia
Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Cancer Program, Monash University, Melbourne, Victoria, Australia
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technical limitations to using PDXs in discovery research. For example, it is more challenging to perform mechanistic studies involving knockdown or over-expression of candidate genes using PDXs compared to cell lines. In vivo genetic screens have been
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expression of genes promoting triglyceride storage ( Zhao et al. 2011 ). Moreover, GH inhibits lipoprotein lipase, the major enzyme responsible for the breakdown of triglycerides into free fatty acids prior to uptake by adipose tissue ( Richelsen et al
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shuttled to the nucleus where they bind on specific DNA sequences (response elements), in gene promotor regions to regulate gene transcription in concert with transcriptional cofactors. In addition, there may be expression of cell membrane-bound sex steroid
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was associated with increased expression of pro-inflammatory cytokines such as tumour necrosis factor α (TNFα), interleukin-1β (IL-1β) and IL-6, which in turn leads to increased expression of the receptor activator of nuclear factor κβ ligand (RANKL