Search Results

You are looking at 1 - 4 of 4 items for :

  • gene expression x
  • 100 years of insulin: A special collection x
  • Refine by access: Content accessible to me x
Clear All
Jennifer M Ikle Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA

Search for other papers by Jennifer M Ikle in
Google Scholar
PubMed
Close
and
Anna L Gloyn Division of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
Stanford Diabetes Research Center, Stanford University, Stanford, California, USA

Search for other papers by Anna L Gloyn in
Google Scholar
PubMed
Close

regulate the gene expression important for both pancreatic islet-cell development as well as glucose metabolism, including the insulin gene itself ( Yamagata et al. 1996 a ). Patients with heterozygous loss-of-function mutations in HNF4A have a

Free access
Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

Search for other papers by Sarah J Richardson in
Google Scholar
PubMed
Close
and
Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

Search for other papers by Alberto Pugliese in
Google Scholar
PubMed
Close

with hyperexpression of HLA class I molecules and insulitis ( Richardson et al. 2009 , 2013 ). There is evidence that enterovirus infections impair beta-cell function ( Gallagher et al. 2015 ), their gene expression, and microRNA regulation ( Kim

Free access
Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

Search for other papers by Jennifer Chen in
Google Scholar
PubMed
Close
and
Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

Search for other papers by Jenny E Gunton in
Google Scholar
PubMed
Close

reported ( Butler et al. 2013 , Yoneda et al. 2013 ). Recent advances in genome sequencing techniques have allowed the mapping of endocrine cell gene expression profile. Chromatin profiling using ATAC-seq (Assay for Transposase Accessible Chromatin

Free access
Pieter-Jan Martens Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

Search for other papers by Pieter-Jan Martens in
Google Scholar
PubMed
Close
,
Conny Gysemans Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

Search for other papers by Conny Gysemans in
Google Scholar
PubMed
Close
, and
Chantal Mathieu Clinical and Experimental Endocrinology (CEE), KU Leuven, Belgium

Search for other papers by Chantal Mathieu in
Google Scholar
PubMed
Close

leucocyte antigen (HLA) genes), activation of the immune system by one or multiple environmental triggers results in a rapid destruction of the pancreatic beta cells ( Eisenbarth 1986 ). This implies a malfunction of the immune system as the culprit. The

Free access