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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
School of Medicine, Mater Research Institute, The Translational Research Institute, Princess Alexandra Hospital, University of Queensland, Herston, Queensland, Australia
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activated BAT. These observations provide persuasive evidence for a significant metabolic role of BAT in humans. Glucocorticoids (GCs) play a critical role in the regulation of energy balance. Chronic GC excess, as exemplified in Cushing's syndrome, results
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Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
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Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, College of Engineering, Wellcome Trust Centre for Biomedical Modelling and Analysis, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
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Introduction Glucocorticoids, the end-product of the hypothalamic–pituitary–adrenal (HPA) axis, are essential hormones that regulate the organism's homeostasis and its response to stress. Glucocorticoids (corticosterone in the rat, cortisol in
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Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
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Centre for Endocrinology, Department of Endocrine Neurobiology, Division of Endocrinology, Oxford Centre for Diabetes, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK
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Introduction Cushing's syndrome results from chronic exposure to high doses of glucocorticoids. Endogenous Cushing's syndrome is rare and may be caused by an adrenocorticotrophin (ACTH)-secreting pituitary adenoma (Cushing's disease) or a cortisol
The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
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The Roslin Institute, University of Edinburgh, Easter Bush Campus, Midlothian, UK
Zhejiang University-University of Edinburgh Institute, International Campus, Haining, Zhejiang, P.R. China
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( Pariante & Lightman 2008 ). The HPA axis is the primary neuroendocrine stress response system. It is activated following perturbations to normal homeostasis, resulting in increased secretion of glucocorticoids from the adrenal gland, which mobilises energy
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–pituitary–adrenal (HPA) axis after mid-gestation leads to increased glucocorticoid levels ( Patrick et al . 1980 , Atkinson & Waddell 1995 ). This HPA axis adaptation is crucial because it promotes the release of energy stores to meet high fetal demand ( Atkinson
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Introduction Glucocorticoids (GCs) have profound influences on many physiological functions, including growth, metabolism, development, behaviors and stress reactions ( Blodgett et al. 1956 , Munck et al. 1984 , Haskett 1985 ). They also
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publications have highlighted the developmental aspects of altered embryonic glucocorticoid exposure in zebrafish ( Hillegass et al . 2008 , Pikulkaew et al . 2011 , De Marco et al . 2013 , Nesan & Vijayan 2013 , 2016 , Faught et al . 2016 ), few
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
Medical Sciences Division, Departments of Biology, Biomolecular Sciences Program, Northern Ontario School of Medicine, Sudbury, Ontario, Canada
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observed that exposure to high doses of glucocorticoids (GCs) during fetal development, generated either as a consequence of maternal stressors or administered antenatally also reduces birth weight and leads to development of essential hypertension later in
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concentrations of the hormone are significantly lower in the target tissue than those in the circulation ( Kolka & Bergman 2012 ). Glucocorticoids are among the most commonly prescribed anti-inflammatory and immunosuppressive medications worldwide ( Clark
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Department of Women’s and Children’s Health, Karolinska Institutet and Pediatric Endocrinology Unit, Karolinska University Hospital, Stockholm, Sweden
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Introduction and background It is estimated that, at any one time, over 250,000 people are exposed to systemic glucocorticoids (GCs); approximately 10% of children will require GCs at some stage during their childhood ( Mushtaq & Ahmed 2002