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Brittany M Duggan, Daniel M Marko, Raveen Muzaffar, Darryl Y Chan, and Jonathan D Schertzer

et al. 2009 ). The purpose of this review is to highlight how SMKIs that are often designed for cancer treatment can alter blood glucose and insulin. We apologize that not all relevant literature could be included in this review. We selected specific

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Binbin Guan, Wenyi Li, Fengying Li, Yun Xie, Qicheng Ni, Yanyun Gu, Xiaoying Li, Qidi Wang, Hongli Zhang, and Guang Ning

is crucial for the development of specific drug treatments for type 2 diabetes. Several mitogens have been implicated in β-cell proliferation, including glucose, insulin-like growth factor 1 (IGF1), placental lactogens (PL), prolactin (PRL

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Zengmin Wang, Gail J Mick, Rongrong Xie, Xudong Wang, Xuemei Xie, Guimei Li, and Kenneth L McCormick

Introduction Circulating adrenal-derived cortisol, which generated intracellularly from cortisone in various tissues, contributes to maintain blood glucose homeostasis. Only the active 11-hydroxy derivatives (cortisol and corticosterone), and

Open access

Kunihisa Hamano, Yuko Nakagawa, Yoshiaki Ohtsu, Longfei Li, Johan Medina, Yuji Tanaka, Katsuyoshi Masuda, Mitsuhisa Komatsu, and Itaru Kojima

Introduction Glucose is a primary stimulator of insulin secretion in pancreatic β-cells and modulates the effects of incretins and acetylcholine ( Ashcroft & Rorsman 1989 , Rasmussen et al . 1990 , Rorsman 1997 , Newsholme et al . 2014 ). We

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Stephan Pinheiro Frankenfeld, Leonardo Pires de Oliveira, Daniele Leão Ignacio, Raquel Guimarães Coelho, Mariana Nigro Mattos, Andrea Claudia Freitas Ferreira, Denise Pires Carvalho, and Rodrigo Soares Fortunato

glucose metabolism, the effects of supraphysiological doses (SDs) of anabolic–androgenic steroids on glucose metabolism are scarce. It is well-known that women with polycystic ovarian syndrome, who have hyperandrogenism, might present hyperinsulinemia with

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Mercedes Lombarte, Brenda L Fina, Maela Lupo, Marília A Buzalaf, and Alfredo Rigalli

world ( Trivedi et al . 1993 ) where fluoride content in drinking water is higher than that recommended by the WHO. Conversely, physical activity improves the effect of insulin on target tissues. Physical activity increases glucose uptake by muscle

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Manami Oya, Tetsuya Kitaguchi, Kazuki Harada, Rika Numano, Takahiro Sato, Masayasu Kojima, and Takashi Tsuboi

arise from nutrient sensing and absorption in the intestine. In fact, in support of this view, recent studies have shown that nutrients (i.e., fatty acids and glucose) and hormones (i.e., insulin and oxytocin) regulate ghrelin secretion in fluorescence

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Nicole G Barra, Fernando F Anhê, Joseph F Cavallari, Anita M Singh, Darryl Y Chan, and Jonathan D Schertzer

function of the microbiota, which relay signals that impact host metabolism and metabolic disease like obesity. Uncovering the complex relationship between diet, gut bacteria, and host metabolism may reveal aspects of how obesity worsens blood glucose

Open access

Antonio Gázquez, Francisca Rodríguez, María Sánchez-Campillo, Lidia E Martínez-Gascón, Marino B Arnao, Pedro Saura-Garre, María D Albaladejo-Otón, and Elvira Larqué

insulin (Novo Nordisk) every morning in order to maintain glycaemia values of mothers between 100 and 400 mg/mL. The units of insulin administered to pregnant rats varied depending on daily glucose values but were similar in both GDM and GDM + ADI groups

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Victoria Diedrich, Elena Haugg, Carola Dreier, and Annika Herwig

proximate signal that decides whether an animal enters torpor on a particular day remains unknown. In the following, we summarize the current state of knowledge about two potential regulatory factors, namely thyroid hormones and glucose, in photoperiodic