, Japan) or a high-fat/high-sucrose diet (HFHSD; protein, 17.2%; lipid, 54.5%; carbohydrate, 28.3% (sucrose, 16.6%) by calories; Oriental Yeast) from 5 weeks of age. All the mice were individually housed. There were eleven MR flox/flox (control) mice aged
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Tomoaki Hayakawa, Tomomi Minemura, Toshiharu Onodera, Jihoon Shin, Yosuke Okuno, Atsunori Fukuhara, Michio Otsuki, and Iichiro Shimomura
Hamza Amine, Yacir Benomar, Adil Haimeur, Hafida Messaouri, Nadia Meskini, and Mohammed Taouis
during a high fat diet in rats ( Storlien et al . 1991 ). Indeed, the substitution of omega-3 fatty acids (w-3 FAs) from fish oil for other types of lipids prevents insulin resistance ( Kraegen et al . 1991 , Jucker et al . 1999 ) and has been
Eliana H Akamine, Anderson C Marçal, João Paulo Camporez, Mara S Hoshida, Luciana C Caperuto, Estela Bevilacqua, and Carla R O Carvalho
to analyze the effect of high-fat diet-induced obesity on the insulin signaling in the ovary. We also verified if insulin signaling impairment is time dependent in relation to the period during which the ovary was submitted to adverse effects of
Bo Ahrén, Maria Sörhede Winzell, and Giovanni Pacini
basis, total energy 16.1 kJ/g) or a high-fat diet (fat 60%, carbohydrate 20%, protein 20% on an energy basis, total energy 22.0 kJ/g) for 8 weeks. The main difference between the two diets is that the high-fat diet has a high content of lard (317 g
Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Julien Astier, Catherine Defoort, Ljubica Svilar, Franck Tourniaire, Lourdes Mounien, and Jean-François Landrier
expression in biopsies of obese compared to lean patients ( Wamberg et al. 2013 ). In mice, Park et al. reported that high fat diet-induced obesity influenced vitamin D metabolizing enzymes expression in liver, kidney and WAT, which could provide a
Jinn-Yang Chen, Deng-Yuan Jian, Chih-Chan Lien, Yu-Ting Lin, Ching-Heng Ting, Luen-Kui Chen, Ting-Chia Hsu, Hsuan-Min Huang, Yu-Ting Wu, Tse-Ting Kuan, Yu-Wen Chao, Liang-Yi Wu, Seng-Wong Huang, and Chi-Chang Juan
). Knight and coworkers found that the expression of glomerular nephrin expression decreases and the urinary albumin level increases in a high-fat (HF) diet model of obesity. Furthermore, hypertension and renal inflammation, which was detected as an increase
Zhiguo Liu, Chun Yan Lim, Michelle Yu-Fah Su, Stephanie Li Ying Soh, Guanghou Shui, Markus R Wenk, Kevin L Grove, George K Radda, Weiping Han, and Xiaoqiu Xiao
, Habbout et al . 2012 ). CPO manipulation results in leptin resistance specifically in the arcuate nucleus of hypothalamus during the early postnatal period that persists into adulthood. When fed with a high-fat diet (HFD), CPO mice exhibit hyperphagia and
Shibin Ding, Ying Fan, Nana Zhao, Huiqin Yang, Xiaolei Ye, Dongliang He, Xin Jin, Jian Liu, Chong Tian, Hongyu Li, Shunqing Xu, and Chenjiang Ying
be really safe. In recent years, life styles dominated by an increase in the consumption of high-fat diets have contributed to the accelerated diabetes epidemic ( Hu 2011 ), and consumption of fat-rich products favors co-exposure to BPA and HFD
Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, and Shi-You Chen
demonstrate that high-fat diet (HFD) dramatically induces RGC32 expression in the adipose tissue. RGC32 deficiency attenuates HFD-induced obesity and insulin resistance in mice. The beneficial effect of RGC32 deficiency is due to the decreased adipose tissue
Anshu Gupta, Malathi Srinivasan, Supaporn Thamadilok, and Mulchand S Patel
establishment of adverse programming effects in the offspring. The present study evaluated the maternal and fetal environments during pregnancy complicated by obesity in rats fed a high-fat (HF) diet. We investigated the signaling pathways of insulin and leptin