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Hiroharu Mifune Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Yusuke Sakai Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yukie Kawahara Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Kento Hara Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Takahiro Sato Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Yoshihiro Nishi Department of Physiology, Kurume University School of Medicine, Kurume, Japan

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Akinori Nishi Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Ryouichi Mitsuzono Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan

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Tatsuyuki Kakuma Bostatistics Center, Kurume University, Kurume, Japan

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Masayasu Kojima Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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behavior, since high levels of GHSR expression are recognized in the dopamine neurons in the VTA ( Zigman et al. 2006 ). It is suggested that ghrelin is involved in the brain reward circuits that are related to motivational properties, as well as hedonic

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0213
Volume/Issue:
Volume 244: Issue 1
Open access
Hiroharu Mifune Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yuji Tajiri Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Yusuke Sakai Institute of Animal Experimentation, Kurume University School of Medicine, Kurume, Japan

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Yukie Kawahara Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Kento Hara Division of Endocrinology and Metabolism, Kurume University School of Medicine, Kurume, Japan

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Takahiro Sato Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Yoshihiro Nishi Department of Physiology, Kurume University School of Medicine, Kurume, Japan

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Akinori Nishi Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan

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Ryouichi Mitsuzono Department of Exercise Physiology, Institute of Health and Sports Science, Kurume University, Kurume, Japan

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Tatsuyuki Kakuma Bostatistics Center, Kurume University, Kurume, Japan

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Masayasu Kojima Molecular Genetics, Life Science Institute, Kurume University, Kurume, Japan

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Article Type:
Correction
DOI:
https://doi.org/10.1530/JOE-19-0213e
Volume/Issue:
Volume 249: Issue 3
Free access
Katie Wynne Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Sarah Stanley Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Barbara McGowan Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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Steve Bloom Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK

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homeostasis, it is now thought to be regulated by neuronal circuits, which signal using specific neuropeptides. The arcuate nucleus (ARC), in particular, is thought to play a pivotal role in the integration of signals regulating appetite. The ARC is

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.1.05866
Volume/Issue:
Volume 184: Issue 2
Free access
Andrea Stojakovic Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
Mitochondrial Neurobiology and Therapeutics Laboratory, Mayo Clinic, Rochester, Minnesota, USA

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Enma P Espinosa Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA
Faculty of Medicine, School of Clinica Biochemistry, Pontifical Catholic University of Ecuador (PUCE), Quito, Ecuador

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Osman T Farhad Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA

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Kabirullah Lutfy Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California, USA

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( Hofstetter et al . 1986 , Perkins 1992 ), and that those effects are the result of the modulatory effect of nicotine on both metabolic processes and reward circuits ( Blendy et al . 2005 , Porter 2017 ). Studies performed in rodents have shown that

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-17-0166
Volume/Issue:
Volume 235: Issue 1
Free access
Jeffrey Friedman Rockefeller University, Box 305, 1230 York Avenue, New York, New York 10065, USA

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, enormous progress has been made in defining a set of overlapping neural circuits that control food intake and body weight. With time, these findings are likely to lead to a deeper understanding of how feeding behavior is controlled as well as our

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0405
Volume/Issue:
Volume 223: Issue 1
Open access
Marc Schneeberger Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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Ramon Gomis Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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Marc Claret Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain
Diabetes and Obesity Research Laboratory, Department of Endocrinology and Nutrition, Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain

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expenditure, contemporary, and lifestyle factors are the main causes of the prevailing obesity epidemics. The present review attempts to summarize current understanding of the anatomy, neurochemistry, functions, and interactions of relevant neural circuits

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0398
Volume/Issue:
Volume 220: Issue 2
Free access
Jennifer S ten Kulve Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Dick J Veltman Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands

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Liselotte van Bloemendaal Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Paul F C Groot Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands

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Henricus G Ruhé Department of Psychiatry, Academic Medical Center, Amsterdam, The Netherlands
University of Groningen, University Medical Center Groningen, Department of Psychiatry, Groningen, The Netherlands

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Frederik Barkhof Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Michaela Diamant Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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Richard G Ijzerman Diabetes Center/Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

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addiction-related stimuli. Obese individuals showed increased responsiveness to viewing pictures of food, which could be regarded as the addictive substance, in areas involved in reward circuits (such as the insula, putamen, caudate nucleus and amygdala

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-15-0461
Volume/Issue:
Volume 229: Issue 1
Free access
L van Bloemendaal
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J S ten Kulve
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S E la Fleur Diabetes Centre, Department of Endocrinology and Metabolism, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands

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R G Ijzerman
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M Diamant
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-homeostatic feeding behaviour is not regulated by hunger and satiety signals but rather by the rewarding properties and motivation related to foods, and involves reward, cognitive and emotional factors. Thus, corticolimbic circuits in humans (including the striatum

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0414
Volume/Issue:
Volume 221: Issue 1
Free access
Marian Joëls Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
University of Groningen, University Medical Center, Groningen, The Netherlands

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E Ronald de Kloet Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

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-tuned balance between MR and GR that upon activation shifts energy resources to circuits and alter their connectivity underlying arousal, emotional expressions of fear and aggression, cognitive performance, motivation, reward and aversion ( Korte et al . 1995

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0660
Volume/Issue:
Volume 234: Issue 1
Free access
Giulia Baldini Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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Kevin D Phelan Department of Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

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-homeostatic, hedonic feeding ( Pandit et al. 2013 , Sternson 2016 ). The brain reward circuit includes many brain areas, such as the ventral tegmental area (VTA), the nucleus accumbens, the LH, the amygdala, the striatum and the prefrontal cortex ( Pandit et al

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0596
Volume/Issue:
Volume 241: Issue 1
Free access