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Marilyn B Renfree School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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Geoff Shaw School of BioSciences, The University of Melbourne, Melbourne, Victoria, Australia

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scrotum, structures that are never seen in XX female young. A full colour version of this figure is available at https://doi.org/10.1530/JOE-22-0296 . Sexual differentiation and direct genetic control of sexual dimorphisms In humans, male

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Gary A Wittert Freemasons Centre for Male Health and Wellbeing, South Australian Health and Medical Research Institute, and University of Adelaide, Adelaide, South Australia, Australia

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Mathis Grossmann Department of Medicine, The University of Melbourne and Department of Endocrinology Austin Health, Heidelberg, Australia

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Bu B Yeap Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia

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David J Handelsman ANZAC Research Institute, University of Sydney and Andrology Department, Concord Hospital, Sydney, New South Wales, Australia

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–69 years from the UK Biobank . Clinical Endocrinology 96 589 – 598 . ( https://doi.org/10.1111/cen.14648 ) McMillin SL Minchew EC Lowe DA & Spangenburg EE 2022 Skeletal muscle wasting: the estrogen side of sexual dimorphism . American Journal

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Kirsty G Pringle School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia
Mothers and Babies Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia

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Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health & School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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biological sex, referred to herein as sex, in the rodent respiratory tract have shown a degree of sexual dimorphism across studies (summarised in Table 1 ). In C57BL6/J mice, females exhibited significantly greater Ace2 mRNA expression in the lung and

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