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Dominique A Glauser and Werner Schlegel

Part I: introduction to FOXO transcription factors Classification and structure of FOXO proteins FOXO transcription factors form a subclass of the large family of Forkhead proteins characterized by the

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David W Scoville, Kristin Lichti-Kaiser, Sara A Grimm, and Anton M Jetten

these results to publicly available data on the genomic binding of several other islet-enriched transcription factors, in order to determine whether GLIS3 regulates pancreatic beta cell gene transcription by binding to distinct regulatory hubs with other

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Jinwon Eo, Kyuyong Han, Kenneth M Murphy, Haengseok Song, and Hyunjung Jade Lim

( Hagglund et al . 1999 ). Etv4 transcription factors belong to superfamily of E26 transformation-specific (Ets) transcription factors. The Ets transcription factors regulate expression of target genes by binding to a ∼10 bp element in the promoters of

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Jinke Wang, Jie Lu, Guangming Gu, and Yingxun Liu

Introduction Transcription factors (TFs) are central to almost every fundamental cellular process ( Latchman 2008 , Ladunga 2010 ) and account for ∼5–10% of genes in eukaryotes ( Reece-Hoyes et al . 2005 , Adryan & Teichmann 2006 , Ho et al

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Michael Mannstadt, Emily Holick, Wenping Zhao, and Harald Jüppner

orthologs of the Drosophila gene glial cells missing) is a transcription factor which is exclusively expressed during embryonic development in the parathyroid-specific domain that later gives rise to the parathyroid glands ( Kim et al . 1998 , Günther

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Débora Cristina de Moraes, Mario Vaisman, Flavia Lucia Conceição, and Tânia Maria Ortiga-Carvalho

( Kioussi et al . 1999 ), Tpit ( Lamolet et al . 2001 ) and Prop1 ( Sornson et al . 1996 ). Figure 2 Temporal and spatial activation of pituitary transcription factors. In response to the BMP2–FGF8 ventral–dorsal gradient, pituitary cell lineages are

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L Grinius, C Kessler, J Schroeder, and S Handwerger

Introduction Transcription factors of the forkhead (FOXO) family of DNA-binding proteins are involved in regulation of diverse cellular functions, such as differentiation, metabolism, proliferation, and survival (for review see

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Sharon Maor, Doris Mayer, Ronit I Yarden, Adrian V Lee, Rive Sarfstein, Haim Werner, and Moshe Z Papa

flanking the transcription start site is extremely GC-rich, and contains numerous potential binding sites for transcription factor Sp1, a zinc-finger-containing nuclear protein that has been shown to strongly transactivate the IGF-IR promoter ( Beitner

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Eric W-F Lam, Kunal Shah, and Jan J Brosens

. 2002 a , b ), also play a vital role in determining and fine-tuning the transcriptional responses in target cells. Furthermore, certain factors have emerged as important for safeguarding genomic integrity and tissue homeostasis during these rapid cycles

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Xiaoning Li, Junhua Xiao, Yating Fan, Kan Yang, Kai Li, Xin Wang, Yanhua Lu, and Yuxun Zhou

, a database of transcription factor-binding profiles ( ). The productions of each pair of primers covered two to four binding sites of TBX21 with score higher than 5.5. The primers for each gene were listed in Supplementary