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Nathalie Marissal-Arvy INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Rachel Hamiani INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Emmanuel Richard INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Marie-Pierre Moisan INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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Véronique Pallet INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France
INRA, Laboratory of Nutrition and Integrative Neurobiology, INSERM, Nutrition and Integrative Neurobiology, UMR1286, Université de Bordeaux 2, 146, rue Léo Saignat, 33076 Bordeaux Cedex, France

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particularly interested in the LOU/C-inbred rat strain, which was derived from the Wistar strain and has been described as a model of healthy ageing with a long life expectancy ( Alliot et al . 2002 ) and preserved memory capacities ( Kollen et al . 2010

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Sharon E Mitchell Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Ruben Nogueiras Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Kellie Rance Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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D Vernon Rayner Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Sharon Wood Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Carlos Dieguez Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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Lynda M Williams Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain

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, the Lou/C rat is an inbred sub-strain, derived from the Wistar rat. It is reported to exhibit spontaneous caloric restriction, relatively high energy expenditure and a lower body weight, mainly due to lower levels of white adipose tissue (WAT

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Nathalie Marissal-Arvy
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Alexandra Gaumont
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Allan Langlois
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Fabrice Dabertrand
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Marion Bouchecareilh Laboratoire PsyNuGen, Laboratoire des Régulations Neuroendocriniennes, INRA UMR1286, CNRS UMR5226, Université de Bordeaux 2, 146 rue Léo-Saignat, F-33076 Bordeaux, France

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Claudine Tridon
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Pierre Mormede
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comparison of three inbred rat strains, Fischer 344 (F344), LOU/C (LOU), and Lewis (LEW). The F344 strain has been classically used as a model of HPA axis hyperactivity and hyperreactivity to stress, often in comparison with the LEW strain, of which the

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Patricia Joseph-Bravo Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Lorraine Jaimes-Hoy Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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Jean-Louis Charli Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca, Morelos 62250, Mexico

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peptide PVN (mRNA) Arc (mRNA) TSH TT 4 TT 3 Cort References Trh Crh Agrp Npy Cart Pomc Bdnf Lou/C rat vs Wistar ↓ + ↑ * ↑ * ↑ * – + ↓ + ↑ ↑ ↓ – ↓ Mitchell et al

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Véronique Serre-Beinier Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christian Toso Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Philippe Morel Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Carmen Gonelle-Gispert Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Christelle Veyrat-Durebex Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Françoise Rohner-Jeanrenaud Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Calandra Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Roger Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Richard W James Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Xavier Montet Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery
Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Léo Bühler Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Domenico Bosco Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Thierry Berney Surgical Research Unit, Department of Surgery, Laboratory of Metabolism, Infectious Diseases Service, Clinical Diabetes Unit, Radiology, Cell Physiology and Metabolism, Internal Medicine, Department of Surgery

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Gjinovci A Meda P Foti M Rohner-Jeanrenaud F 2009 The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue . American Journal of Physiology. Endocrinology

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Shu-Fang Xia Wuxi School of Medicine, Jiangnan University, Wuxi, China
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Xiao-Mei Duan State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China
Shandong Sport Training Center, Jinan, China

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Xiang-Rong Cheng State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Li-Mei Chen Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Yan-Jun Kang Wuxi School of Medicine, Jiangnan University, Wuxi, China

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Peng Wang COFCO Corporation Oilseeds Processing Division, Beijing, China

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Xue Tang State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Yong-Hui Shi State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Guo-Wei Le State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China

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Soares AF Lagarde M Geloen A 2008 Lou/C obesity-resistant rat exhibits hyperactivity, hypermetabolism, alterations in white adipose tissue cellularity, and lipid tissue profiles . Endocrinology 149 615 – 625 . ( doi:10.1210/en.2007

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Jie Xu INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Amaury Jean-Marie Bekaert INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Joëlle Dupont INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Sarah Rouve INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Isabella Annesi-Maesano INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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C Daniel De Magalhaes Filho INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France
INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Laurent Kappeler INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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Martin Holzenberger INSERM U938, Université Pierre-et-Marie-Curie, INRA, INSERM U707, Hôpital Saint-Antoine, Bâtiment Kourilsky, 184 rue du Faubourg Saint-Antoine, F-75012 Paris, France

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pulsatile secretion and increased orexigenic peptide expression in the Lou C/JaLL rat . Neuroendocrinology 80 273 – 283 doi:10.1159/000083610 . Kappeler L De Magalhaes Filho C Dupont J Leneuve P Cervera P Périn L Loudes C Blaise A Klein

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Koen D Flach Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Wilbert Zwart Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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Jin S Lou C 2009 AIB1 is required for the acquisition of epithelial growth factor receptor-mediated tamoxifen resistance in breast cancer cells . Biochemical and Biophysical Research Communications 380 699 – 704 . ( doi:10.1016/j

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Stephanie L Clookey Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Rebecca J Welly Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Terese M Zidon Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Michelle L Gastecki Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Makenzie L Woodford Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Zachary I Grunewald Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Nathan C Winn Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Dusti Eaton Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Natalia G Karasseva Transgenic Animal Core, University of Missouri, Columbia, Missouri, USA

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Harold S Sacks Endocrine and Diabetes Division, Veterans Greater Los Angeles Healthcare System, Los Angeles, California, USA

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Jaume Padilla Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA
Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri, USA
Department of Child Health, University of Missouri, Columbia, Missouri, USA

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Victoria J Vieira-Potter Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA

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Altirriba J Montet X Colin DJ Caillon A Lyautey J Rohner-Jeanrenaud F 2015 Ectopic UCP1 overexpression in white adipose tissue improves insulin sensitivity in Lou/C Rats, a Model of Obesity Resistance Lou . Diabetes 64 3700 – 3712 . ( https

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