Search Results

You are looking at 1 - 10 of 626 items for :

  • Refine by access: Content accessible to me x
Clear All
Alexander Hennebry AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Alexander Hennebry in
Google Scholar
PubMed
Close
,
Jenny Oldham AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Jenny Oldham in
Google Scholar
PubMed
Close
,
Tea Shavlakadze School of Anatomy, Physiology & Human Biology, The University of Western Australia, Crawley, Western Australia, Australia

Search for other papers by Tea Shavlakadze in
Google Scholar
PubMed
Close
,
Miranda D Grounds School of Anatomy, Physiology & Human Biology, The University of Western Australia, Crawley, Western Australia, Australia

Search for other papers by Miranda D Grounds in
Google Scholar
PubMed
Close
,
Philip Sheard Department of Physiology, University of Otago, Dunedin, New Zealand

Search for other papers by Philip Sheard in
Google Scholar
PubMed
Close
,
Marta L Fiorotto USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA

Search for other papers by Marta L Fiorotto in
Google Scholar
PubMed
Close
,
Shelley Falconer AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Shelley Falconer in
Google Scholar
PubMed
Close
,
Heather K Smith Department of Exercise Sciences, University of Auckland, Auckland, New Zealand

Search for other papers by Heather K Smith in
Google Scholar
PubMed
Close
,
Carole Berry AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Carole Berry in
Google Scholar
PubMed
Close
,
Ferenc Jeanplong AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Ferenc Jeanplong in
Google Scholar
PubMed
Close
,
Jeremy Bracegirdle AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Jeremy Bracegirdle in
Google Scholar
PubMed
Close
,
Kenneth Matthews AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Kenneth Matthews in
Google Scholar
PubMed
Close
,
Gina Nicholas AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Gina Nicholas in
Google Scholar
PubMed
Close
,
Mônica Senna-Salerno AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Mônica Senna-Salerno in
Google Scholar
PubMed
Close
,
Trevor Watson AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Trevor Watson in
Google Scholar
PubMed
Close
, and
Christopher D McMahon AgResearch Ltd, Hamilton, New Zealand

Search for other papers by Christopher D McMahon in
Google Scholar
PubMed
Close

binds and activates activin type 2B receptors to promote phosphorylation of Smad2/3 ( Rebbapragada et al. 2003 ), while IGF1 activates the IGF1 receptor and phosphorylates PI3 kinase (PI3K) and AKT ( Rommel et al. 2001 ). The PI3K/AKT pathway is

Free access
Toya M Albury-Warren Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA

Search for other papers by Toya M Albury-Warren in
Google Scholar
PubMed
Close
,
Veethika Pandey Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA

Search for other papers by Veethika Pandey in
Google Scholar
PubMed
Close
,
Lina P Spinel Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA

Search for other papers by Lina P Spinel in
Google Scholar
PubMed
Close
,
Michal M Masternak Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA
Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA

Search for other papers by Michal M Masternak in
Google Scholar
PubMed
Close
, and
Deborah A Altomare Burnett School of Biomedical Sciences, Department of Head and Neck Surgery, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32827, USA

Search for other papers by Deborah A Altomare in
Google Scholar
PubMed
Close

Introduction AKT, a serine/threonine kinase, is downstream of phosphatidylinositol-3-kinase (PI3K) and growth factor receptors (e.g. epidermal growth factor receptor), and is a hallmark signaling protein predominantly recognized for regulation of

Free access
A Tsuchiya Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

Search for other papers by A Tsuchiya in
Google Scholar
PubMed
Close
,
T Kanno Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

Search for other papers by T Kanno in
Google Scholar
PubMed
Close
, and
T Nishizaki Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan

Search for other papers by T Nishizaki in
Google Scholar
PubMed
Close

Introduction Akt is a serine/threonine protein kinase bearing multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration. Akt includes three closely related isoforms Akt1, Akt2, and Akt3

Open access
Olivier Le Bacquer UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by Olivier Le Bacquer in
Google Scholar
PubMed
Close
,
Gurvan Queniat UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by Gurvan Queniat in
Google Scholar
PubMed
Close
,
Valery Gmyr UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by Valery Gmyr in
Google Scholar
PubMed
Close
,
Julie Kerr-Conte UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by Julie Kerr-Conte in
Google Scholar
PubMed
Close
,
Bruno Lefebvre UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by Bruno Lefebvre in
Google Scholar
PubMed
Close
, and
François Pattou UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France
UMR859, INSERM UMR859, INSERM UMR837, CHU Lille, Faculty of Medicine, Université Lille Nord de France, 1 Place de Verdun, F-59000 Lille, France

Search for other papers by François Pattou in
Google Scholar
PubMed
Close

& Sonenberg 2004 , Wullschleger et al . 2006 ). mTORC1 and mTORC2 are two distinct complexes sharing mTOR as a catalytic subunit. mTORC1 is composed of mTOR, regulated associated protein of mTOR (raptor), proline-rich Akt substrate of 40 kDa (PRAS40), and G

Free access
Kimberley C W Wang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by Kimberley C W Wang in
Google Scholar
PubMed
Close
,
Kimberley J Botting Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by Kimberley J Botting in
Google Scholar
PubMed
Close
,
Song Zhang Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by Song Zhang in
Google Scholar
PubMed
Close
,
I Caroline McMillen Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by I Caroline McMillen in
Google Scholar
PubMed
Close
,
Doug A Brooks Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by Doug A Brooks in
Google Scholar
PubMed
Close
, and
Janna L Morrison Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia

Search for other papers by Janna L Morrison in
Google Scholar
PubMed
Close

factor 2 receptor (IGF-2R) and angiotensin II type 1 receptor (AT 1 R)-mediated Akt signaling as molecular foundations for the association between low birth weight and cardiovascular disease in adulthood. Cardiomyocyte development during fetal life

Free access
Rupasri Ain Institute of Maternal-Fetal Biology and Division of Cancer and Developmental Biology, Departments of Pathology and Laboratory of Medicine, Molecular and Integrative Physiology, and Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA

Search for other papers by Rupasri Ain in
Google Scholar
PubMed
Close
,
Lindsey N Canham Institute of Maternal-Fetal Biology and Division of Cancer and Developmental Biology, Departments of Pathology and Laboratory of Medicine, Molecular and Integrative Physiology, and Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA

Search for other papers by Lindsey N Canham in
Google Scholar
PubMed
Close
, and
Michael J Soares Institute of Maternal-Fetal Biology and Division of Cancer and Developmental Biology, Departments of Pathology and Laboratory of Medicine, Molecular and Integrative Physiology, and Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA

Search for other papers by Michael J Soares in
Google Scholar
PubMed
Close

the Ser/Thr protein kinase, Akt (also called protein kinase B) ( Chan et al. 1999 , Datta et al. 1999 ). Akt activation can stimulate changes in gene transcription, cell survival, cell division, and cell differentiation. In the present

Free access
Shi-Yan Li Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Shi-Yan Li in
Google Scholar
PubMed
Close
,
Cindy X Fang Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Cindy X Fang in
Google Scholar
PubMed
Close
,
Nicholas S Aberle II Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Nicholas S Aberle II in
Google Scholar
PubMed
Close
,
Bonnie H Ren Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Bonnie H Ren in
Google Scholar
PubMed
Close
,
Asli F Ceylan-Isik Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Asli F Ceylan-Isik in
Google Scholar
PubMed
Close
, and
Jun Ren Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, Wyoming 82071, USA

Search for other papers by Jun Ren in
Google Scholar
PubMed
Close

be triggered by activation of its upstream molecules phosphatidylinositol 3 (PI-3) kinase and the serine/threonine kinase PKB/Akt ( Hornberger et al. 2004 , Oudit et al. 2004 ). Meanwhile, increased levels of nutrients, growth factors such as

Free access
Manon M Roustit
Search for other papers by Manon M Roustit in
Google Scholar
PubMed
Close
,
Joan M Vaughan Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Joan M Vaughan in
Google Scholar
PubMed
Close
,
Pauline M Jamieson Department of Comparative Biomedical Sciences, Laboratory of Neuronal Structure and Function, Queen's Medical Research Institute, Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK

Search for other papers by Pauline M Jamieson in
Google Scholar
PubMed
Close
, and
Mark E Cleasby
Search for other papers by Mark E Cleasby in
Google Scholar
PubMed
Close

/2, AKT and PKCε activation ( Brar et al . 2002 , 2004 , Lawrence et al . 2005 ). UCN2 and CRFR2 are both expressed in mouse skeletal muscle ( Chen et al . 2004 , Keipert et al . 2013 ), where they inhibit atrophy and promote hypertrophy ( Hinkle

Open access
Hong-Zhi Sun
Search for other papers by Hong-Zhi Sun in
Google Scholar
PubMed
Close
,
Tong-Wei Yang Key Laboratory of Environment and Genes Related to Diseases, First Affiliated Hospital of Jilin University, Ministry of Education, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, People's Republic of China

Search for other papers by Tong-Wei Yang in
Google Scholar
PubMed
Close
,
Wei-Jin Zang
Search for other papers by Wei-Jin Zang in
Google Scholar
PubMed
Close
, and
Shu-Fang Wu
Search for other papers by Shu-Fang Wu in
Google Scholar
PubMed
Close

), suggesting that NFKB may regulate the expression of AR. The activation of AKT and NFKB has been involved in the progression of PCa from androgen dependence to independence ( Murillo et al . 2001 , Kikuchi et al . 2003 ). The phosphatidylinositol 3-kinase

Free access
Hong Xu Department of Gastroenterology and Hepatology, Hangzhou Red Cross Hospital, Hangzhou, China

Search for other papers by Hong Xu in
Google Scholar
PubMed
Close
,
Yang Zhou Liver Cirrhosis Section, Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Search for other papers by Yang Zhou in
Google Scholar
PubMed
Close
,
Yongxia Liu Department of Clinical Laboratory, Hangzhou Red Cross Hospital, Hangzhou, China

Search for other papers by Yongxia Liu in
Google Scholar
PubMed
Close
,
Jian Ping Liver Cirrhosis Section, Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Search for other papers by Jian Ping in
Google Scholar
PubMed
Close
,
Qiyang Shou Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China

Search for other papers by Qiyang Shou in
Google Scholar
PubMed
Close
,
Fangming Chen Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, China

Search for other papers by Fangming Chen in
Google Scholar
PubMed
Close
, and
Ru Ruo Department of Pathology, Hangzhou Red Cross Hospital, Hangzhou, China

Search for other papers by Ru Ruo in
Google Scholar
PubMed
Close

( Ahmadieh & Azar 2014 ). In the liver, the insulin receptor substrate 2 (IRS2)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling transduction pathway plays a pivotal role in modulating the glucose metabolic actions of insulin ( Pessin

Free access