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John N Stabley Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA

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Rhonda D Prisby Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA

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Bradley J Behnke Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA
Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA

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Michael D Delp Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA
Department of Applied Physiology and Kinesiology, Department of Kinesiology and Applied Physiology, Department of Kinesiology, Department of Nutrition, University of Florida, Gainesville, Florida 32611, USA

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, Prisby et al . 2012 ). Cardiovascular disease is a leading complication of T2DM ( Grundy et al . 1999 ), including impairment of endothelium-dependent vasodilation of large conduit arteries ( Hogikyan et al . 1998 , Makimattila et al . 1999 , van de

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0514
Volume/Issue:
Volume 225: Issue 1
Free access
Rhonda D Prisby Department of Kinesiology, University of Texas at Arlington, Arlington, Texas, USA

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. The attenuated femoral bone blood flow with advanced age corresponded with reduced endothelium-dependent vasodilation of the femoral PNA ( Prisby et al. 2007 ). Blood flow in long bones are regionally dependent; i.e., hematopoietic marrow and the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-16-0666
Volume/Issue:
Volume 235: Issue 3
Free access
Inmaculada C Villar
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Adrian J Hobbs
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Amrita Ahluwalia Department of Pharmacology, Clinical Pharmacology, University College London, Medical Sciences Building, Gower Street, London WC1E 6BT, UK

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contribute to the beneficial effects in the cardiovascular system i.e. estrogen-induced or enhanced activation of the endothelium. It is now accepted that changes in endothelial function are instrumental in the vascular inflammation that is an early and

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-08-0070
Volume/Issue:
Volume 197: Issue 3
Free access
B Torondel
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JM Vila
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G Segarra
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P Lluch
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P Medina
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J Martinez-Leon
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J Ortega
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S Lluch
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The functional properties of the endothelium of human thyroid arteries remain unexplored. We investigated the intervention of nitric oxide (NO), prostacyclin (PGI(2)) and endothelium-derived hyperpolarizing factor (EDHF) in the responses to acetylcholine and noradrenaline in isolated thyroid arteries obtained from multi-organ donors. Artery rings were suspended in organ baths for isometric recording of tension. The contribution of NO, PGI(2) and EDHF to endothelium-dependent relaxation was determined by the inhibitory effects of N(G)-monomethyl-L-arginine (L-NMMA), indomethacin, and K(+) channel inhibitors respectively. Acetylcholine induced concentration-dependent relaxation; this effect was not modified by indomethacin and was only partly reduced by L-NMMA, but was abolished in endothelium-denuded rings. The relaxation resistant to indomethacin and L-NMMA was abolished by using either apamin combined with charybdotoxin, ouabain plus barium, or a high-K(+) solution. Noradrenaline induced concentration-dependent contractions which were of greater magnitude in arteries denuded of endothelium or in the presence of L-NMMA.In conclusion, the results indicate that in human thyroid arteries the endothelium significantly modulates responses to acetylcholine and noradrenaline through the release of NO and EDHF. EDHF plays a dominant role in acetylcholine-induced relaxation through activation of Ca(2+)-activated K(+) channels, inwardly rectifying K(+) channels and Na(+)-K(+)-ATPase.

Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1810379
Volume/Issue:
Volume 181: Issue 3
Free access
Verónica Torres-Estay Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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Daniela V Carreño Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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Ignacio F San Francisco Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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Paula Sotomayor Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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Alejandro S Godoy Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile
Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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Gary J Smith Departamento de Fisiología, Urología, Center for Integrative Medicine and Innovative Sciences, Department of Urology, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile

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increased monocyte binding to the endothelium. The pathway leading to VCAM-1 expression was dependent of the interaction of functional AR with the NF-κB signaling pathway ( Death et al . 2004 , Nheu et al . 2011 ). In addition, testosterone rapidly

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0611
Volume/Issue:
Volume 224: Issue 3
Free access
Derek S Boeldt Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Mary A Grummer Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ronald R Magness Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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Ian M Bird Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA
Perinatal Research Laboratories, Department of Pediatrics, Department of Animal Sciences, Department of Obstetrics and Gynecology, School Medicine and Public Health, University of Wisconsin–Madison, 7E Meriter Hospital/Park, 202 South Park Street, Madison, Wisconsin 53715, USA

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expression as determinants of NO output in uterine artery endothelium: relative roles in pregnancy adaptation and reversal by VEGF 165 . American Journal of Physiology. Heart and Circulatory Physiology 300 H1182 – H1193 . ( doi:10.1152/ajpheart.01108

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0252
Volume/Issue:
Volume 223: Issue 1
Free access
Pablo H Cutini Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina
Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina

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Adrián E Campelo Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina
Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina

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Virginia L Massheimer Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina
Cátedra de Bioquímica Clínica II, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS), San Juan 670, B8000ICN, Bahía Blanca, Argentina

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Introduction The endothelium is the main regulator of vascular physiology that contributes to maintaining vascular tone and non-thrombogenic properties of the endothelial surface. Endothelial nitric oxide (NO) is a key factor in vascular homeostasis

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-13-0263
Volume/Issue:
Volume 220: Issue 3
Free access
Jiean Xu State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Qiuhua Yang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Xiaoyu Zhang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zhiping Liu State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yapeng Cao State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Lina Wang State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yaqi Zhou State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Xianqiu Zeng State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Qian Ma State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China
Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Yiming Xu Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China

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Yong Wang Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China

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Lei Huang Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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Zhen Han Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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Tao Wang Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, Shenzhen, China

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David Stepp Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Zsolt Bagi Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA

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Mei Hong State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, China

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Yuqing Huo Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

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Introduction Vascular endothelium plays a crucial role in the regulation of metabolic homeostasis, and dysregulated endothelial function induces the development of metabolic disorders ( Graupera & Claret 2018 , Pi et al. 2018 ). Multiple

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-19-0126
Volume/Issue:
Volume 242: Issue 2
Free access
Hao Wu Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
The ‘973’ National Basic Research Program of China, Changchun University of Chinese Medicine, Changchun, Jilin, People’s Republic of China

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Junduo Wu Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Shengzhu Zhou Department of Anesthesiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Wenlin Huang School of Science and Technology, Georgia Gwinnett College, Lawrenceville, Georgia, USA

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Ying Li Department of Dermatology, Affiliated Hospital of Beihua University, Jilin, Jilin, People’s Republic of China

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Huan Zhang Operating Theatre, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Junnan Wang Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Ye Jia Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

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Biotechnology; 1:100), SIRT1 (Abcam; 1:100) and acetylated P53 (Ac-P53, Abcam; 1:100). IHC-positive area was quantified within the full-thickness of the artery wall, including endothelium, tunica media and tunica externa. Selection of areas to photograph and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-17-0672
Volume/Issue:
Volume 237: Issue 1
Free access
Charlotte Lawson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Jose M Vicencio Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Derek M Yellon Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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Sean M Davidson Department of Comparative Biomedical Sciences, The Hatter Cardiovascular Institute, Royal Veterinary College, Royal College Street, London NW1 0TU, UK

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excess androgen activity, oligo-ovulation or anovulation, and polycystic ovaries ( Teede et al . 2010 ). The role EVs in the function and dysfunction of healthy and diseased endothelium A number of studies have demonstrated a correlation between the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0201
Volume/Issue:
Volume 228: Issue 2
Free access