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100 YEARS OF INSULIN: Pancreas pathology in type 1 diabetes: an evolving story

Sarah J Richardson

Sarah J Richardson Islet Biology Group, Exeter Centre for Excellence in Diabetes (EXCEED), Institute of Biomedical and Clinical Sciences (IBCS), University of Exeter, RILD Level 4, Exeter, UK

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Alberto Pugliese

Alberto Pugliese Division of Diabetes Endocrinology and Metabolism, Departments of Medicine, Microbiology and Immunology, Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami, Miami, Florida, USA

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and B lymphocytes, macrophages, and less frequently, natural killer cells ( Dotta et al. 2007 , Willcox et al. 2009 ). A consensus definition of insulitis was published in 2013 ( Campbell-Thompson et al. 2013 ), and describes insulitis as a

Article Type:: Review Article

Collections:: 100 years of insulin: A special collection, Top-cited articles of 2023

DOI:: https://doi.org/10.1530/JOE-21-0358

Volume/Issue:: Volume 252: Issue 2

Free access

Beta-cell function and human islet transplantation: can we improve?

Jennifer Chen

Jennifer Chen The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia

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Jenny E Gunton

Jenny E Gunton The Westmead Institute for Medical Research, The University of Sydney Westmead Hospital, New South Wales, Australia
Department of Endocrinology and Diabetes, Westmead Hospital, Sydney, New South Wales, Australia
Garvan Institute of Medical Research, Sydney, New South Wales, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

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vitamin B3 isotype ( Moberg et al. 2003 ) has been proposed to treat this. This compound has also been implicated in the prevention of macrophage mediated destruction of rodent islets ( Kolb et al. 1990 ). In a syngeneic islet transplant mouse model