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Rodrigo S Fortunato Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil

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Andrea C F Ferreira Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil

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Fabio Hecht Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil
Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil

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Corinne Dupuy Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil

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Denise P Carvalho Laboratory of Molecular Radiobiology, Laboratory of Endocrine Physiology, Mixed Unity of Research (UMR) 8200 – Genomes and Cancer, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS - Bloco G - Subsolo - Sala G0-031, Cidade Universitária - Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, Brazil

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propose that ROS could be involved in the sexual dimorphism found in thyroid dysfunctions. Future studies are necessary to evaluate the involvement of NOX4-generated ROS in the estrogen-signaling pathway in thyrocytes. Elucidating this issue is crucial to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-13-0588
Volume/Issue:
Volume 221: Issue 2
Free access
Filip Callewaert Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Mieke Sinnesael Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Evelien Gielen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Steven Boonen Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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Dirk Vanderschueren Center for Musculoskeletal Research, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

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the pathophysiology of osteoporosis and osteoporotic fracture risk in men. Skeletal gender differences in radial bone growth (skeletal sexual dimorphism) are traditionally attributed to stimulatory ‘male’ androgen action as opposed to inhibitory

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-10-0209
Volume/Issue:
Volume 207: Issue 2
Free access
Julia N C Toews Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Geoffrey L Hammond Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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Victor Viau Department of Cellular & Physiological Sciences, The University of British Columbia, Vancouver, Canada

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testosterone surge therefore establishes the sexual dimorphism of hypothalamic and pituitary mediators of GH pulsatility that emerge as testicular testosterone production resumes at puberty. This results in sex-specific patterns of GH pulsatility that affect

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-20-0286
Volume/Issue:
Volume 248: Issue 1
Free access
Andrés J López-Contreras Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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Jesús D Galindo Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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Carlos López-García Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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Maria T Castells Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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Asunción Cremades Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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Rafael Peñafiel Biochemistry and Molecular Biology B and Immunology, Pharmacology, Departments of

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there is a marked sexual extra-genital dimorphism in the kidney, liver, and skeletal muscle in several mouse strains, affecting many different proteins ( Bardin & Catterall 1981 ). In particular, renal ornithine decarboxylase (ODC) activity is remarkably

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-07-0564
Volume/Issue:
Volume 196: Issue 3
Free access
Michelle P Marassi Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Rodrigo S Fortunato Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Alba C Matos da Silva Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Valmara S Pereira Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Denise P Carvalho Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Doris Rosenthal Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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Vânia M Corrêa da Costa Laboratório de Fisiologia Endócrina, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS-Bloco G-Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21949-900, Brazil

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act as a potent stimulus of D1 activity. In the female groups, liver and renal D1 activities were higher in pre-pubertal than in adult rats, without significant differences in thyroid and pituitary activities. In fact, after sexual maturation, liver

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06901
Volume/Issue:
Volume 192: Issue 1
Free access
Paz Vital Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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Elena Larrieta Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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Marcia Hiriart Biophysics Department, Institute of Cellular Physiology, Universidad Nacional Autónoma de México, Mexico City, 04510, DF, Mexico AP 70-253, Mexico

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). Discussion We observed sexual dimorphism in insulin sensitivity, function and morphology of prepubertal, pubertal, and adult rat pancreatic islets, and susceptibility to develop diabetes. To our knowledge, this is the first report showing that serum

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06596
Volume/Issue:
Volume 190: Issue 2
Free access
Melissa F Jackson School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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Dung Luong School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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Dor Dor Vang School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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Dilip K Garikipati School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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James B Stanton School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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O Lynne Nelson School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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Buel D Rodgers School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of
School of Molecular Biosciences, Veterinary Microbiology and Pathology, Animal Sciences, Departments of

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shown). Lean fat-free mass was greater in both sexes of Mstn −/− mice and total and percent body fat content was less ( Fig. 1 A), particularly in females. This sexual dimorphism in adiposity among Mstn −/− mice is highly novel and to our knowledge

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-11-0455
Volume/Issue:
Volume 213: Issue 3
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KL Gatford
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AR Egan
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IJ Clarke
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PC Owens
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Article Type:
Other
DOI:
https://doi.org/10.1677/joe.0.1570373
Volume/Issue:
Volume 157: Issue 3
Free access
Gabriela Capllonch-Amer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Miquel Sbert-Roig Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Bel M Galmés-Pascual Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Ana M Proenza Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Isabel Lladó Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Magdalena Gianotti Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Francisco J García-Palmer Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain
Grup Metabolisme Energètic i Nutrició, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBERobn, Departament de Biologia Fonamental i Ciències de la Salut, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa, km 7,5. E-07122 Palma de Mallorca, Illes Balears, Spain

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Introduction Sexual dimorphism in mitochondrial functionality has been described in many rat tissues such as liver, adipose tissue, brain, and skeletal muscle ( Colom et al . 2007 a , b , Valle et al . 2007 a , b , Gómez-Pérez et al . 2008

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-14-0008
Volume/Issue:
Volume 221: Issue 3
Free access
Geoffrey Raisman Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK

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influences through the brain to the control of the endocrine system ( Vogt 1972 , Raisman 1997 ). And, as anticipated by Marshall, it was the influence of light on reproduction that would be a royal route of investigation. Sexual dimorphism in the brain I

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-15-0049
Volume/Issue:
Volume 226: Issue 2
Free access