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Yasminye D Pettway Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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Diane C Saunders Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Marcela Brissova Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, Vanderbilt University Medical Center, Nashville, Tennessee, USA

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Hydrolase Exp Exp Exp Exp HIGD1A HIG1 hypoxia inducible domain family member 1A Scaffold/adaptor protein Exp Exp Exp Exp IRX2 Iroquois homeobox 2 Homeodomain transcription factor Exp Exp Exp Exp KCTD12

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0298
Volume/Issue:
Volume 258: Issue 1
Free access
Elliott P Brooks Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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Lori Sussel Barbara Davis Center for Diabetes, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA

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stages referred to as ‘transitions’ and is orchestrated in large part by the timely expression of transcription factors ( Fig. 1 ). With limited access to human fetal tissue less is known about corresponding human pancreas development; however, several

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0297
Volume/Issue:
Volume 258: Issue 2
Free access
Rui Gao Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Samuel Acreman Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
Department of Physiology, Institute of Neuroscience and Physiology, Metabolic Research Unit, University of Gothenburg, Göteborg, Sweden

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Jinfang Ma Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK

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Fernando Abdulkader Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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Anna Wendt Department of Clinical Sciences Malmö, Islet Cell Exocytosis, Lund University Diabetes Centre, Lund University, Malmö, Sweden

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Quan Zhang Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK
CNC - Center for Neuroscience and Cell Biology, CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal

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may become defective in diabetes. A brief history of α-cells Although glucagon has not received as much attention as insulin, its history is almost as long ( Fig. 1 , a simplified timeline). The first description of a pancreatic factor that

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-22-0295
Volume/Issue:
Volume 258: Issue 2
Open access
Sarah L Armour Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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Jade E Stanley Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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James Cantley Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK

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E Danielle Dean Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Division of Diabetes, Endocrinology, & Metabolism, Vanderbilt University Medical Center School of Medicine, Nashville, Tennessee, USA

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Jakob G Knudsen Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Denmark

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-1298 ) Rakhshandehroo M Hooiveld G Müller M & Kersten S 2009 Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human . PLoS One 4 e6796 . ( https://doi.org/10.1371/journal.pone.0006796 ) Rocha DM Faloona GR

Article Type:
Review Article
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100 years of glucagon: Anniversary collection
DOI:
https://doi.org/10.1530/JOE-23-0081
Volume/Issue:
Volume 259: Issue 1
Free access