The aim of the present study has been to discover whether the total urinary excretion of neutral 17-ketosteroids is affected by division of the nerves supplying the adrenal glands, with or without complete removal of one adrenal gland.
During treatment for essential hypertension, selected patients undergo bilateral splanchnicectomy resulting in complete section of the nerve supply of the adrenal glands, and in addition right-sided adrenalectomy may be performed. It is thought that in women the urinary 17-ketosteroids are derived from the adrenals only, and that the ovaries probably play no part in their production, since öophorectomy does not significantly alter the excretion [Callow, 1938; Callow, Callow & Emmens, 1940; Fraser, Forbes, Albright, Sulkowitch, Reifenstein, 1941; Ross, Hamblen, Cuyler & Baptist, 1941; Hamblen, Cuyler & Baptist, 1941]. Further, negligibly small assays have been reported in women suffering from Addison's disease [Fraser et al. 1941].
Accordingly two female patients undergoing surgical treatment