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Gemma Llauradó, Victòria Ceperuelo-Mallafré, Carme Vilardell, Rafael Simó, Pilar Gil, Albert Cano, Joan Vendrell, and José-Miguel González-Clemente

Klimek K Olczyk K 2012 Plasma biomarkers of oxidative and AGE-mediated damage of proteins and glycosaminoglycans during healthy ageing: a possible association with ECM metabolism . Mechanisms of Ageing and Development 133 538 – 548 . ( doi:10

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M I Rodriguez, G Escames, L C López, J A García, F Ortiz, A López, and D Acuña-Castroviejo

Biochemistry 74 214 –226. Hosokawa M 2002 A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice. Mechanisms of Ageing and Development 123 1553 –1561

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Natalia Ogonowski, Giselle Piro, Déborah Pessah, Noelia Arreche, Bernardita Puchulu, Ana M Balaszczuk, and Andrea L Fellet

, resulting in an NO-mediated regulation of the heart pacemaker activity ( Fellet et al. 2004 , 2006 , 2008 ). Additionally, we demonstrated that hypothyroidism contributes in a differential way to ageing-induced changes in the myocardium and aorta tissues

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Renata Lopes Araujo, Bruno Moulin de Andrade, Álvaro Souto Padron de Figueiredo, Monique Leandro da Silva, Michelle Porto Marassi, Valmara dos Santos Pereira, Eliete Bouskela, and Denise P Carvalho

energy restricted mice . Mechanisms of Ageing and Development 73 209 – 221 . De Herder WW Bonthuis F Rutgers M Otten MH Hazenberg MP Visser TJ 1988 Effects of inhibition of type 1 iodothyronine deiodinase and phenol sulfotransferase on the

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Daniela Fernandois, Gonzalo Cruz, Eun Kyung Na, Hernán E Lara, and Alfonso H Paredes

during ageing in the rat . Reproductive Biology and Endocrinology 7 64 . ( doi:10.1186/1477-7827-7-64 ) Altarejos JY Goebel N Conkright MD Inoue H Xie J Arias CM Sawchenko PE Montminy M 2008 The Creb1 coactivator

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Nicola A Dennis, Gregory T Jones, Yih Harng Chong, Andre M van Rij, and Ian S McLennan

remodelling of blood vessels during ageing. If so, clues to the functions of AMH may be obtained by determining whether AMH associates with either the physical characteristics of their blood vessels or particular cardiovascular conditions. We have therefore

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Clare F Hodkinson, Ellen E A Simpson, John H Beattie, Jacqueline M O'Connor, David J Campbell, J J Strain, and Julie M W Wallace

16 63 – 70 . Chakraborti S Chakraborti T Mandal M Das S Batabyal SK 1999 Hypothalamic–pituitary–thyroid axis status of humans during development of ageing process . Clinica Chimica Acta 288 137 – 145 . Chiovato L Mariotti S

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Jodi L Downs and Henryk F Urbanski

, O’Brien P & Nair KS 1998 Disruption of the relationship between fat content and leptin levels with ageing in humans. Journal of Clinical Endocrinology and Metabolism 83 931 –934. Muehlenbein MP , Campbell BC

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S A Lanham, A L Fowden, C Roberts, C Cooper, R O C Oreffo, and A J Forhead

declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Funding This work was supported by the BBRSC (grant number S18103) and Research into Ageing (grant number 253). Acknowledgements

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Paula J Brunton, Katie M Sullivan, David Kerrigan, John A Russell, Jonathan R Seckl, and Amanda J Drake

resistance ( Kim et al . 2000 , Muoio et al . 2002 ). Importantly, ageing exacerbates the phenotypic abnormalities associated with Ppar α deficiency ( Atherton et al . 2009 ), which might also exacerbate the phenotype associated with PNS. The finding of