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Piotr Zabielski, Marta Chacinska, Karol Charkiewicz, Marcin Baranowski, Jan Gorski, and Agnieszka U Blachnio-Zabielska

Whole-body insulin sensitivity HFD-fed animals developed IR, as evidenced by elevated fasting blood glucose ( Supplementary Table 1 ), impaired glucose tolerance ( Fig. 2A and B ), reduced insulin responsiveness ( Fig. 2C and D ) and increased HOMA

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Jiean Xu, Qiuhua Yang, Xiaoyu Zhang, Zhiping Liu, Yapeng Cao, Lina Wang, Yaqi Zhou, Xianqiu Zeng, Qian Ma, Yiming Xu, Yong Wang, Lei Huang, Zhen Han, Tao Wang, David Stepp, Zsolt Bagi, Chaodong Wu, Mei Hong, and Yuqing Huo

mice were fed ad libitum either a normal chow diet (CD) or a high-fat diet (HFD) (D12492, Research Diets) for 12 weeks followed by analysis of insulin sensitivity. Evaluation of energy homeostasis Food intake, locomotor activity and energy

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Marleen B Dommerholt, Derek A Dionne, Daria F Hutchinson, Janine K Kruit, and James D Johnson

hyperinsulinemia, exhibit long-term protection against diet-induced-obesity and eventually improved insulin sensitivity and prolonged lifespan ( Mehran et al. 2012 , Templeman et al. 2015 , 2016 , 2017 ). To investigate the relationship of insulin and the

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Guohong Liu, Mirta Grifman, James Macdonald, Peter Moller, Flossie Wong-Staal, and Qi-Xiang Li

-deficient mice ( Yamauchi et al. 2003 a ). Administration of adiponectin in diet-induced obesity mice increased insulin sensitivity and reduced body weight ( Fruebis et al. 2001 , Shklyaev et al. 2003 ). In humans, insulin-resistant states such as obesity

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Gary J Remington, Celine Teo, Virginia Wilson, Araba Chintoh, Melanie Guenette, Zohra Ahsan, Adria Giacca, and Margaret K Hahn

et al . 2010 a , Teff et al . 2013 , Hahn et al . 2014 ). In this regard, our own work from preclinical rodent models consistently supports pronounced, direct effects on insulin sensitivity (peripheral and hepatic) following acute dosing of

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Alison V Roland, Craig S Nunemaker, Susanna R Keller, and Suzanne M Moenter

no change in insulin sensitivity or maximal insulin-stimulated glucose uptake, but higher basal glucose uptake in PNA adipocytes (basal: 4.0±0.5 amol/glc per min per cell CON, 6.4±1.0 PNA, n =5 each, P <0.05; at 0.1 nM insulin: 17.4±2.4 CON, 20

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Paolo Comeglio, Ilaria Cellai, Tommaso Mello, Sandra Filippi, Elena Maneschi, Francesca Corcetto, Chiara Corno, Erica Sarchielli, Annamaria Morelli, Elena Rapizzi, Daniele Bani, Daniele Guasti, Gabriella Barbara Vannelli, Andrea Galli, Luciano Adorini, Mario Maggi, and Linda Vignozzi

development is related to increased size and volume of adipocytes, which are closely related to insulin sensitivity ( Bedossa et al. 2016 ). Bile acids (BAs) are hormone-like signaling molecules that regulate glucose and lipid metabolism as well as energy

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C Ortega-González, L Cardoza, B Coutiño, R Hidalgo, G Arteaga-Troncoso, and A Parra

an improvement in insulin sensitivity. Materials and Methods The study protocol was approved by the Internal Review Board and the Human Ethical Committee of the Instituto Nacional de Perinatología, México City, México and

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Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant’Ana, Guilherme Francisco Peruca, Ana Paula Morelli, Fernando M Simabuco, Adelino S R da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli, and Leandro Pereira de Moura

oligonucleotide – ASO), it was possible to observe an improvement in insulin sensitivity, a reduction in endogenous glucose production, and, consequently, a reduction in hyperglycemia in obese rodents ( Kumashiro et al. 2013 ). Furthermore, the authors showed

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T J Kowalski, B D Spar, L Markowitz, M Maguire, A Golovko, S Yang, C Farley, J A Cook, G Tetzloff, L Hoos, R A Del Vecchio, T M Kazdoba, M F McCool, J J Hwa, L A Hyde, H Davis, G Vassileva, J A Hedrick, and E L Gustafson

homeostasis in mice that broadly express a transgene encoding murine proNmU. The results of this analysis show that NmU transgenic (Tg) mice maintained on a chow diet are leaner than wild-type mice and hypophagic, and have increased insulin sensitivity, while