Search Results

You are looking at 91 - 100 of 250 items for :

  • "steatosis" x
  • All content x
Clear All
Free access

Chunyan Zhao and Karin Dahlman-Wright

needs to address that LXR activation is associated with stimulation of lipogenesis resulting in increased plasma TG levels and hepatic steatosis. Several in vivo studies have shown that rodents treated with T0901317 have massive TG accumulation in the

Free access

Michael Mangubat, Kabirullah Lutfy, Martin L Lee, Laura Pulido, David Stout, Richard Davis, Chang-Sung Shin, Meghdi Shahbazian, Stephen Seasholtz, Amiya Sinha-Hikim, Indrani Sinha-Hikim, Laura E O'Dell, Alexei Lyzlov, Yanjun Liu, and Theodore C Friedman

the HFD plus nicotine is actually a more beneficial combination than HFD alone. However, several recent animal studies have shown that cigarette smoking exacerbates hepatic steatosis triggered by HFD ( Liu et al . 2003 , Chen et al . 2007 a , Yuan

Free access

Shaodong Guo

et al . (2012) Liver Foxo4 −/− Normal glucose levels Alb-cre Zhang et al . (2012) Liver Foxo1 −/− ∷ Foxo3 −/− ∷ Foxo4 −/ − Reduced blood glucose levels; increased triglyceride levels; hepatic steatosis Alb-cre Haeusler et al . (2010) and Zhang

Free access

Greg M Kowalski, Michael J Kraakman, Shaun A Mason, Andrew J Murphy, and Clinton R Bruce

:10.1152/ajpendo.90996.2008 ) Meex RC Hoy AJ Morris A Brown RD Lo JC Burke M Goode RJ Kingwell BA Kraakman MJ Febbraio MA 2015 Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose

Free access

Nailliw Z Preite, Bruna P P do Nascimento, Cynthia R Muller, Anna Laura V Américo, Talita S Higa, Fabiana S Evangelista, Carmen L Lancellotti, Felipe dos Santos Henriques, Miguel Luiz Batista Jr, Antonio C Bianco, and Miriam O Ribeiro

feeding on a HFD resulted in a severe macrovesicular liver steatosis, with triglyceride accumulation in large hepatocyte vacuoles but similar in WT and ARβ 3 KO ( Fig. 5C , D and E ). HFD-induced glucose intolerance was similar in both groups ( Fig. 6

Free access

Sun-O Ka, Mi-Young Song, Eun Ju Bae, and Byung-Hyun Park

cytokines in the liver and adipose tissue and an increase in the number of CLSs. Notably, mS1KO mice on a HFD showed a decrease in hepatic triglycerides and steatosis and smaller adipocyte size compared with WT mice. These findings are in contrast to those

Free access

Zhongxiuzi Gao, Li Zhang, Wenting Xie, Siqi Wang, Xiaorui Bao, Yuli Guo, Houjian Zhang, Qingzhong Hu, Yi Chen, Zeen Wang, Maoqiang Xue, and Guanghui Jin

53 1087 – 1097 . ( doi:10.1369/jhc.5C6684.2005 ) Cao Y Xue Y Xue L Jiang X Wang X Zhang Z Yang J Lu J Zhang C Wang W 2013 Hepatic menin recruits SIRT1 to control liver steatosis through histone

Free access

I Sadaf Farooqi and Stephen O'Rahilly

et al . 1999 ). In those who survive, obesity continues in adult life, with hepatic steatosis ( von Schnurbein et al . 2013 ) and hyperinsulinaemia consistent with the severity of obesity. Some adults have developed type 2 diabetes in the third to

Free access

Martina Bugáňová, Helena Pelantová, Martina Holubová, Blanka Šedivá, Lenka Maletínská, Blanka Železná, Jaroslav Kuneš, Petr Kačer, Marek Kuzma, and Martin Haluzík

toxic insult, increased taurine synthesis and consequently taurine excretion into urine also. Obesity and insulin resistance are commonly associated with liver steatosis ( Fabbrini et al. 2010 ); therefore, the significant decrease in urine taurine

Free access

Alia H Sukkar, Aaron M Lett, Gary Frost, and Edward S Chambers

hepatic steatosis by dietary supplementation of SCFAs over a period of 12 weeks. One of the possible underlying mechanisms was the decrease in peroxisome proliferator-activated receptor gamma ( Pparg ) activity in the liver. Pparg increases energy