potential epigenetic processes involved and the impact of alterations in the early periods of developmental plasticity on epigenetic regulation of adipokines. As an example, programming-mediated changes in methylation of the suppressor of cytokine signalling
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Clare M Reynolds and Mark H Vickers
Johanna G Miquet, Lorena González, Marina N Matos, Christina E Hansen, Audreen Louis, Andrzej Bartke, Daniel Turyn, and Ana I Sotelo
family of suppressors of cytokine-signaling (SOCS) proteins, which is involved in targeting receptor complexes for internalization and signal termination and was also reported to compete with STAT5b for binding sites in GHR ( Ram & Waxman 2000 , Landsman
Patrik Šimják, Anna Cinkajzlová, Kateřina Anderlová, Antonín Pařízek, Miloš Mráz, Michal Kršek, and Martin Haluzík
, Anderlova et al . 2006 ). Early hyperleptinemia is a predictor of GDM risk ( Qiu et al . 2004 ), and it precedes the changes in maternal glycemia ( Gao et al . 2008 ). Interestingly, mice lacking the suppressor of cytokine signaling 3 gene ( Socs3 ) in
Elias Rawish, Laura Nickel, Franziska Schuster, Ines Stölting, Alex Frydrychowicz, Kathrin Saar, Norbert Hübner, Alaa Othman, Lars Kuerschner, and Walter Raasch
observed to activate NF-κB (nuclear factor kappa B) in cultured hypothalamic neurons ( Jang et al. 2010 ), which can induce SOCS3 (suppressor of cytokine signaling 3) and PTP1B (protein tyrosine phosphatase 1B) expression and result in leptin resistance
Kleber L A Souza, Ewa Gurgul-Convey, Matthias Elsner, and Sigurd Lenzen
. Trends in Biotechnology 23 128 – 134 . Ronn SG Billestrup N Mandrup-Poulsen T 2007 Diabetes and suppressors of cytokine signaling proteins . Diabetes 56 541 – 548 . Saldeen J 2000 Cytokines induce both necrosis and apoptosis via a common Bcl-2
Urszula T Iwaniec and Russell T Turner
Role of suppressors of cytokine signaling 3 in bone inflammatory responses . Frontiers in Immunology 4 506 . ( doi:10.3389/fimmu.2013.00506 ) Gat-Yablonski G Ben-Ari T Shtaif B Potievsky O Moran O Eshet R Maor G Segev
Harman S Mattu and Harpal S Randeva
an increase in levels of suppressor of cytokine signalling 3 (SOCS3) – an inhibitor of leptin signalling ( Enriori et al . 2006 ). Leptin acts on target cells through plasma membrane receptors that include at least six isoforms, Ob-Ra through Ob
Katie Wynne, Sarah Stanley, Barbara McGowan, and Steve Bloom
. 1996 ) required for signal transduction. The JAK/STAT pathway induces expression of a suppressor of cytokine signalling-3 (SOCS-3), one of a family of cytokine-inducible inhibitors of signalling. Obesity in the db / db mouse is the result
Giulia Baldini and Kevin D Phelan
& Friedman 1999 , Banks et al. 2000 , Bjorbak et al. 2000 ). An effect of STAT3 activation by the occupied LepR is to initiate the feedback inhibitory pathway to induce expression of suppressor of cytokine signaling-3 (Socs3) mRNA ( Fig. 2B ). Socs3
