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inhibit inflammatory signaling. SOCS2, which is a member of a family of suppressor of cytokine signaling proteins, is more highly expressed in the livers of WKY animals (Supplementary Table 2). SOCS2 interacts with another negative regulator of cytokine

. Trends in Biotechnology 23 128 – 134 . Ronn SG Billestrup N Mandrup-Poulsen T 2007 Diabetes and suppressors of cytokine signaling proteins . Diabetes 56 541 – 548 . Saldeen J 2000 Cytokines induce both necrosis and apoptosis via a common Bcl-2

Role of suppressors of cytokine signaling 3 in bone inflammatory responses . Frontiers in Immunology 4 506 . ( doi:10.3389/fimmu.2013.00506 ) Gat-Yablonski G Ben-Ari T Shtaif B Potievsky O Moran O Eshet R Maor G Segev

, Anderlova et al . 2006 ). Early hyperleptinemia is a predictor of GDM risk ( Qiu et al . 2004 ), and it precedes the changes in maternal glycemia ( Gao et al . 2008 ). Interestingly, mice lacking the suppressor of cytokine signaling 3 gene ( Socs3 ) in

potential epigenetic processes involved and the impact of alterations in the early periods of developmental plasticity on epigenetic regulation of adipokines. As an example, programming-mediated changes in methylation of the suppressor of cytokine signalling

an increase in levels of suppressor of cytokine signalling 3 (SOCS3) – an inhibitor of leptin signalling ( Enriori et al . 2006 ). Leptin acts on target cells through plasma membrane receptors that include at least six isoforms, Ob-Ra through Ob

. 1996 ) required for signal transduction. The JAK/STAT pathway induces expression of a suppressor of cytokine signalling-3 (SOCS-3), one of a family of cytokine-inducible inhibitors of signalling. Obesity in the db / db mouse is the result

& Friedman 1999 , Banks et al. 2000 , Bjorbak et al. 2000 ). An effect of STAT3 activation by the occupied LepR is to initiate the feedback inhibitory pathway to induce expression of suppressor of cytokine signaling-3 (Socs3) mRNA ( Fig. 2B ). Socs3