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, Anderlova et al . 2006 ). Early hyperleptinemia is a predictor of GDM risk ( Qiu et al . 2004 ), and it precedes the changes in maternal glycemia ( Gao et al . 2008 ). Interestingly, mice lacking the suppressor of cytokine signaling 3 gene ( Socs3 ) in

. Trends in Biotechnology 23 128 – 134 . Ronn SG Billestrup N Mandrup-Poulsen T 2007 Diabetes and suppressors of cytokine signaling proteins . Diabetes 56 541 – 548 . Saldeen J 2000 Cytokines induce both necrosis and apoptosis via a common Bcl-2

observed to activate NF-κB (nuclear factor kappa B) in cultured hypothalamic neurons ( Jang et al. 2010 ), which can induce SOCS3 (suppressor of cytokine signaling 3) and PTP1B (protein tyrosine phosphatase 1B) expression and result in leptin resistance

potential epigenetic processes involved and the impact of alterations in the early periods of developmental plasticity on epigenetic regulation of adipokines. As an example, programming-mediated changes in methylation of the suppressor of cytokine signalling

family of suppressors of cytokine-signaling (SOCS) proteins, which is involved in targeting receptor complexes for internalization and signal termination and was also reported to compete with STAT5b for binding sites in GHR ( Ram & Waxman 2000 , Landsman

inhibit inflammatory signaling. SOCS2, which is a member of a family of suppressor of cytokine signaling proteins, is more highly expressed in the livers of WKY animals (Supplementary Table 2). SOCS2 interacts with another negative regulator of cytokine

Role of suppressors of cytokine signaling 3 in bone inflammatory responses . Frontiers in Immunology 4 506 . ( doi:10.3389/fimmu.2013.00506 ) Gat-Yablonski G Ben-Ari T Shtaif B Potievsky O Moran O Eshet R Maor G Segev

an increase in levels of suppressor of cytokine signalling 3 (SOCS3) – an inhibitor of leptin signalling ( Enriori et al . 2006 ). Leptin acts on target cells through plasma membrane receptors that include at least six isoforms, Ob-Ra through Ob

. 1996 ) required for signal transduction. The JAK/STAT pathway induces expression of a suppressor of cytokine signalling-3 (SOCS-3), one of a family of cytokine-inducible inhibitors of signalling. Obesity in the db / db mouse is the result

& Friedman 1999 , Banks et al. 2000 , Bjorbak et al. 2000 ). An effect of STAT3 activation by the occupied LepR is to initiate the feedback inhibitory pathway to induce expression of suppressor of cytokine signaling-3 (Socs3) mRNA ( Fig. 2B ). Socs3