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Patrice D Cani, Catherine A Daubioul, Brigitte Reusens, Claude Remacle, Grégory Catillon, and Nathalie M Delzenne

.) ( Delzenne 2003 , Delzenne et al. 2003 ). We have shown in previous studies that oligofructose – a short chain fructan obtained from inulin -decreases steatosis by reducing spontaneous food intake in obese Zucker Fa/Fa rats ( Daubioul et al. 2002

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Milos Mraz and Martin Haluzik

migration ( Gerhardt et al . 2001 , Christiansen et al . 2005 ). Overexpression of MCP1 leads to ATM infiltration, IR, and liver steatosis without increasing body weight, while deletion of MCP1 or macrophage CCR2 reduces ATM numbers in AT and improves

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M K Piya, P G McTernan, and S Kumar

. ↑ Preadipocyte cell proliferation, as with TNFα Sporn et al . (1987) and Fain et al . (2005) MCP1 Increases insulin resistance, macrophage infiltration in adipose tissue and hepatic steatosis Secreted by WAT ↑ ob/ob and db/db mice. ↑ In obesity, T2DM and

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Haijiang Wu, Xinna Deng, Yonghong Shi, Ye Su, Jinying Wei, and Huijun Duan

inhibitor ameliorates hepatic steatosis by improving ER stress and inflammation in a type 2 diabetic mouse model . PLoS ONE 10 e0120711 . ( doi:10.1371/journal.pone.0120711 ) Knutti D Kaul A Kralli A 2000 A tissue-specific coactivator of

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Folami Y Ideraabdullah, Anthony M Belenchia, Cheryl S Rosenfeld, Seth W Kullman, Megan Knuth, Debabrata Mahapatra, Michael Bereman, Edward D Levin, and Catherine A Peterson

generation offspring of VDD dams displayed greater body and epididymal fat mass ( Nascimento et al. 2013 ). These mice also had increased insulin secretion when given an oral glucose challenge and showed marked hepatic steatosis. An in utero VDD Sprague

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A Feraco, A Armani, R Urbanet, A Nguyen Dinh Cat, V Marzolla, F Jaisser, and M Caprio

2010 Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet . Endocrinology 151 2040 – 2049 . ( https

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Camila Martinez Calejman, Juan M Di Gruccio, María E Mercau, Esteban M Repetto, Francisco Astort, Rocío Sanchez, Matías Pandolfi, Gabriela Berg, Laura Schreier, Pablo Arias, and Cora B Cymeryng

accumulation has been detected in nonadipose tissues as pancreas, kidneys, blood vessels, skeletal muscle, and heart. In this sense, Zago et al . (2010) demonstrated an increase in liver weight and moderate hepatic micro- and macrovesicular steatosis in

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Zhengu Liu, Violeta Stanojevic, Luke J Brindamour, and Joel F Habener

insulin resistance. This circumstance manifests in hyperglycemia, hyperlipidemia, hypertension, atherosclerosis, and steatosis of major organs such as the liver (nonalcoholic fatty liver disease), heart (lipotoxic cardiomyopathy), brain (Alzheimer

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S J Brandt, M Kleinert, M H Tschöp, and T D Müller

liraglutide alone and also improves lipid metabolism and hepatic steatosis ( Choi et al. 2017 , Kim et al. 2017 ). A third example, Syn-GIP-ZP, is a triple agonist created by fusing a GLP-1R/GCGR dual agonist and a GIP analog to the heavy and light

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Hsiu-Chi Lee and Shaw-Jenq Tsai

repression of β-oxidation. In experimental obesity models, intermittent hypoxia exposure worsens the insulin intolerance and hepatic steatosis. Hepatocyte-specific Hif-1α knockout mice fed with high-fat diet exhibit glucose intolerance. Hepatic ablation of