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Andrew W Norris, Katie Larson Ode, Lina Merjaneh, Srinath Sanda, Yaling Yi, Xingshen Sun, John F Engelhardt, and Rebecca L Hull

( Andersen 1958 ). In line with this, pancreatic volume, estimated by MRI, is decreased in CF compared to healthy controls and to patients with type 1 diabetes (note, however, pancreas could only be visualized in a small subset of CF subjects; Sequeiros et

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Che-Pei Kung and Maureen E Murphy

characterized by high blood glucose, caused either by inadequate insulin production in the body or by impaired response to insulin. Type 1 diabetes accounts for approximately 10% of cases, and is caused by death and dysfunction of pancreatic beta islet cells

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Kristen E Syring, Karin J Bosma, Slavina B Goleva, Kritika Singh, James K Oeser, Christopher A Lopez, Eric P Skaar, Owen P McGuinness, Lea K Davis, David R Powell, and Richard M O’Brien

‘TT’ (0.0809). PheWAS analyses showed that the SLC30A8 rs13266634 ‘T’ allele is associated with decreased risk for type 1 diabetes (T1D) (OR = 0.90, CI = 0.85–0.94, P  = 3.60E-06), T2D (OR = 0.94, CI = 0.92–0.97, P  = 1.04E-05) and T2D with

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G Burnstock and I Novak

nucleotide/nucleoside levels at tumors sites ( Pellegatti et al . 2008 , Yegutkin et al . 2011 ). Diabetes and pancreas In type 1 diabetes (or insulin-dependent diabetes mellitus) pancreatic β-cells are destroyed/defective and treatment with exogenous

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Masaki Nagaya, Hitoshi Katsuta, Hideaki Kaneto, Susan Bonner-Weir, and Gordon C Weir

Introduction There is great hope that transplantation of insulin-producing cells will be a cure-equivalent for type 1 diabetes ( Shapiro et al . 2000 , Ricordi & Strom 2004 ), however, two major challenges remain: the shortage of available tissue

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Ynuk Bossé

The mutual exclusion of type 1 diabetes, a disease in which insulin is deficient, and asthma led to the suspicion that insulin may contribute to asthma ( Stene & Nafstad 2001 ). Association studies that report relationships between insulin and asthma

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Ernest Sargsyan, Henrik Ortsäter, Kristofer Thorn, and Peter Bergsten

2 but not type 1 diabetes . Diabetes 56 2016 – 2027 . Karaskov E Scott C Zhang L Teodoro T Ravazzola M Volchuk A 2006 Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1

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Cesidio Giuliani, Ines Bucci, Valeria Montani, Dinah S Singer, Fabrizio Monaco, Leonard D Kohn, and Giorgio Napolitano

class-I and class-II molecules is increased in pancreatic β islet cells of patients with type 1 diabetes mellitus, in muscle biopsies of patients with inflammatory myopathies, and in thyroid epithelial cells (TECs) from patients with autoimmune thyroid

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Sanhua Leng, Wenshuo Zhang, Yanbin Zheng, Ziva Liberman, Christopher J Rhodes, Hagit Eldar-Finkelman, and Xiao Jian Sun

type 1 diabetes, it can be concluded that hyperglycemia certainly does not require secondary hyperinsulinemia to antagonize insulin function. However, even in insulin-free systems, the mechanism of hyperglycemia-induced insulin resistance is unclear

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Kok Lim Kua, Shanming Hu, Chunlin Wang, Jianrong Yao, Diana Dang, Alexander B Sawatzke, Jeffrey L Segar, Kai Wang, and Andrew W Norris

offspring of women with gestational diabetes mellitus or type 1 diabetes: the role of intrauterine hyperglycemia . Diabetes Care 31 340 – 346 . ( ) 10.2337/dc07-1596 18000174 Clausen TD Mathiesen ER Hansen T Pedersen