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Bo Chen, Yanrong Lu, Younan Chen, and Jingqiu Cheng

. Oxidative stress, hypoxia, and flow disturbances are important factors that are related to endothelial dysfunction ( Coleman et al . 2013 ). Reactive oxygen species (ROS) are free radicals and reactive metabolites that contain oxygen molecules with unpaired

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Bohan Wang, I Stuart Wood, and Paul Trayhurn

hypoxia-inducible factor 1 . Journal of Biological Chemistry 277 34601 – 34609 . Carriere A Carmona M-C Fernandez Y Rigoulet M Wenger RH Penicaud L Casteilla L 2004 Mitochondrial reactive oxygen species control the transcription factor CHOP

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A Tury, G Mairet-Coello, F Poncet, C Jacquemard, P Y Risold, D Fellmann, and B Griffond

2 O 2 ( Makino et al. 1996 ). A rapidly increasing body of evidence indicates that reactive oxygen species, in particular H 2 O 2, could play an important role as signaling molecules involved, for example, in cellular proliferation or activation

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Kenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Satoshi Takeda, Ryohei Kawasaki, Ken Aizawa, and Koichi Endo

increased oxidative stress derived from vascular NADPH oxidase in vascular tissue. Recent reports demonstrated that increased oxidative stress via NADPH oxidase induced endothelial dysfunction in OVX rat ( Camporez et al . 2011 ). Increased reactive oxygen

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Amanda J Genders, Timothy Connor, Shona Morrison, Simon T Bond, Brian G Drew, Peter J Meikle, Kirsten F Howlett, and Sean L McGee

through a DG-independent mechanism that is initiated in response to mitochondrial-derived reactive oxygen species, which involves phosphorylation of the regulatory domain by c-Abl and Src kinase ( Storz et al. 2003 , 2005 ). Once activated, PKD

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K H Al-Gubory, S Camous, G Germain, P Bolifraud, A Nicole, and I Ceballos-Picot

luteolysis ( McGuire et al. 1994 ) and after exogenous administration of PGF 2α during the midluteal phase ( McGuire et al. 1994 , Murdoch 1995 ). The generation of reactive oxygen species (ROS) within the CL has been suggested to be involved in the

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Ruslan Rafikov, Fabio V Fonseca, Sanjiv Kumar, Daniel Pardo, Charles Darragh, Shawn Elms, David Fulton, and Stephen M Black

. Another consideration is that, even after dimer dissociation, the monomeric eNOS retains its heme and can continue to interact with reactive oxygen species (ROS) such as H 2 O 2 ( Porasuphatana et al . 2001 , Woodward et al . 2009 ). This would result

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Tsutomu Wada, Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi Tsuneki, and Toshiyasu Sasaoka

scrambled negative control (Thermo Fisher Scientific) were incorporated into BMDM using TransIT-TKO transfection reagent (Mirus Bio LLC, Madison, WI, USA), as described in the manufacturers’ protocol. Detection of reactive oxygen species (ROS

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Juliana Gastão Franco, Egberto Gaspar de Moura, Josely Correa Koury, Paula Affonso Trotta, Aline Cordeiro, Luana Lopes Souza, Norma Aparecida dos Santos Almeida, Natália da Silva Lima, Carmen Cabanelas Pazos-Moura, Patrícia Cristina Lisboa, and Magna Cottini Fonseca Passos

health are still unclear. In recent years, it has been shown that long-term ER decreases the levels of oxidative damage to cellular macromolecules mainly by reducing the rate of mitochondrial reactive oxygen species (ROS) generation in rodents ( Gredilla

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Mitra Arianmanesh, Rebecca H McIntosh, Richard G Lea, Paul A Fowler, and Kaïs H Al-Gubory

.05) lower in CL of pregnant ewes ( Table 2 ). Validation of selected proteins It was not possible to identify all the protein spots of interest and representative examples were identified by LC–MS/MS. Tightly controlled reactive oxygen species (ROS