, therefore increasing insulin sensitivity. Recent studies have shown that by increasing the volume of BAT through cold exposure, glucose clearance also improves ( van der Lans et al . 2013 , Chondronikola et al . 2014 ). However, this requires constant
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Victor A Gault, David W Porter, Nigel Irwin, and Peter R Flatt
.p. glucose tolerance (18 mmol/kg body weight) test and insulin sensitivity (10 U/kg body weight) test were similarly performed at 1000 h in freely fed mice. The i.p. route was chosen as the method of glucose delivery, as this will bypass the stomach and
Jin-Bong Lee, Sung-Jin Yoon, Sang-Hyun Lee, Moo-Seung Lee, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon, Inpyo Choi, Ik-Soo Kim, Su Wol Chung, Hee Gu Lee, Jeong-Ki Min, and Young-Jun Park
adipose tissue expansion is considered beneficial and is marked by improved insulin sensitivity, reduced angiogenesis, reduced dysfunctional adipocyte hypertrophy and increases in fibrosis, hypoxia and the infiltration of M1 adipose tissue macrophages and
Elena Maneschi, Annamaria Morelli, Sandra Filippi, Ilaria Cellai, Paolo Comeglio, Benedetta Mazzanti, Tommaso Mello, Alessandra Calcagno, Erica Sarchielli, Linda Vignozzi, Farid Saad, Roberto Vettor, Gabriella B Vannelli, and Mario Maggi
and obesity and testosterone treatment of hypogonadal patients improves insulin sensitivity and reduces fat mass ( Corona et al . 2011 a ). Despite this evidence, the pathogenetic link and the clinical significance of MetS-associated male hypogonadism
Salvatore P Mangiafico, Shueh H Lim, Sandra Neoh, Helene Massinet, Christos N Joannides, Joseph Proietto, Sofianos Andrikopoulos, and Barbara C Fam
insulin sensitivity in young and adult PEPCK transgenic and Piebald Virol Glaxo (PVG/c) control rats. The results showed that a primary increase in glucose production did not lead to glucose intolerance, due to normal hepatic and peripheral insulin
A Corbould
Introduction Adipose tissue is now recognized to play a central role in determining whole body insulin sensitivity ( Minokoshi et al. 2003 ). In animal models, insulin resistance in adipose tissue secondarily results in insulin
Monique C Saleh, Michael B Wheeler, and Catherine B Chan
determine if the age-related changes in glucose tolerance (as measured by the ins:gluc ratio, Table 1 ) of ob/ob mice were related to changes in tissue insulin sensitivity. The 16-week-old lean mice were more sensitive to insulin than ob/ob mice in any
Shin-Ichi Kato, Katsuyoshi Sato, Haruka Chida, Sang-Gun Roh, Shyuichi Ohwada, Shusuke Sato, Paul Guilloteau, and Kazuo Katoh
insulin sensitivity. In veal calves, milk feeding for a long period was demonstrated to cause insulin resistance. The responses of plasma glucose and insulin to a MF ingestion in calves became greater by aging and remained elevated for more than 6 h after
Melanie Tran, Linda A Gallo, Andrew J Jefferies, Karen M Moritz, and Mary E Wlodek
rats born small due to uteroplacental insufficiency, although confounded by obesity, pregnancy unmasked maternal diabetes that led to macrosomic F2 offspring with increased adiposity, impaired glucose tolerance, and reduced insulin sensitivity ( Boloker
Sarah L Craig, Victor A Gault, Gerd Hamscher, and Nigel Irwin
glucose, insulin, GIP and GLP-1, as well as glucose and pyruvate tolerance, peripheral insulin sensitivity, expression of key genes involved in liver glucose metabolism and insulin action, as well as DPP-4 activity and pancreatic islet morphology were
