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Mariana Renovato Martins, Anatalia Kutianski Gonzalez Vieira, Érica Patrícia Garcia de Souza, and Anibal Sanchez Moura

disturbances, and diminished peripheral insulin sensitivity. Materials and Methods Animals and treatments Virgin female Swiss mice were time crossed at 3 months of age. During pregnancy, they were singly housed under standard conditions. After birth, litters

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Peter J Simons, Petra S van den Pangaart, Johannes M F G Aerts, and Louis Boon

activate different signaling pathways and exert different functions ( Trujillo & Scherer 2005 ). Importantly, the ratio of HMW:total adiponectin, but not absolute levels of adiponectin, has been proposed to correlate with insulin sensitivity in mice and

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Liselotte Fransson, Stephanie Franzén, Victoria Rosengren, Petra Wolbert, Åke Sjöholm, and Henrik Ortsäter

as postprandial blood glucose fell to levels similar to those seen in vehicle-treated animals ( Fig. 2 A and B). In addition, insulin sensitivity, measured via an IPinsTT after 3 weeks without corticosterone, was normalized ( Fig. 2 D). The

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F González, N S Rote, J Minium, and J P Kirwan

a 2-h value of 140–199 mg/dl, and type 2 diabetes mellitus defined as a 2-h value of 200 mg/dl or greater ( Modan et al. 1989 ). Insulin sensitivity was estimated by IS HOMA by the following formula ( Matthews et al. 1985 ): fasting glucose

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Sophie M T Wehrens, Shelagh M Hampton, Rebecca E Finn, and Debra J Skene

associated with CVD (e.g. Taheri et al . 2004 , Gangwisch et al . 2006 ). In agreement with these reports, laboratory studies have demonstrated decreased glucose tolerance and insulin sensitivity after partial sleep deprivation, restricting sleep to

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Abigail Wolf Greenstein, Neena Majumdar, Peng Yang, Papasani V Subbaiah, Rhonda D Kineman, and Jose Cordoba-Chacon

, TZDs increase systemic insulin sensitivity, which in turn reduces insulin demands. These changes are associated with an increase in adiponectin production by the adipocyte. Adiponectin in turn promotes hepatic fatty acid oxidation via phosphorylation of

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Soo Bong Choi, Jin Sun Jang, Sang Mee Hong, Dong Wha Jun, and Sunmin Park

. Willi SM , Kennedy A, Wallace P, Ganaway E, Rogers NL & Garvey WT 2002 Troglitazone antagonizes metabolic effects of glucocorticoids in humans: effects on glucose tolerance, insulin sensitivity, suppression of free fatty acids, and leptin. Diabetes

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Helena A Walz, Linda Härndahl, Nils Wierup, Emilia Zmuda-Trzebiatowska, Fredrik Svennelid, Vincent C Manganiello, Thorkil Ploug, Frank Sundler, Eva Degerman, Bo Ahrén, and Lena Stenson Holst

reduced insulin sensitivity. We used a mouse model that exhibits modest, 2-fold overexpression of the cAMP-degenerating enzyme PDE3B in β-cells. Previous control experiments, conducted by us ( Härndahl et al. 2002 ), demonstrate the direct effect of

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Susan Gray, Barbara S Stonestreet, Shanthie Thamotharan, Grazyna B Sadowska, Molly Daood, Jon Watchko, and Sherin U Devaskar

in fetal skeletal muscle GLUT 1 and GLUT 4 concentrations most likely reflects a compensatory response to increase substrate availability/utilization and heightened fetal insulin sensitivity. However, in previous work when fetal growth restriction

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A Feraco, A Armani, R Urbanet, A Nguyen Dinh Cat, V Marzolla, F Jaisser, and M Caprio

the cardiovascular system ( Latouche et al. 2012 , Tarjus et al. 2015 ). Moreover, NGAL is a novel adipokine whose expression is increased in AT of obese subjects ( Catalan et al. 2009 ) and NGAL-knockout mice show improved insulin sensitivity