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Kely de Picoli Souza, Francemilson Goulart da Silva, and Maria Tereza Nunes

increased VW/BW ratio, anticipation of the DEO (11th day of life), and decreased T4 serum concentration (Table 1 and Fig. 3 ) are important physiological indications of the hyperthyroid state, considering the well-known effects of TH inducing cardiac

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Raylene A Reimer, Gary J Grover, Lee Koetzner, Roland J Gahler, Michael R Lyon, and Simon Wood

the final day of the study, following an overnight fast and regular drug treatment, rats were over-anesthetized with isoflurane and a cardiac blood sample collected. Total cholesterol concentration was measured in the blood using an automated analyzer

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P W F Hadoke, R S Lindsay, J R Seckl, B R Walker, and C J Kenyon

aldosterone levels in both groups. Continuous infusion of Ang II below the threshold required for an immediate vasoconstrictor response is a widely used protocol for investigating long-term pressor effects, including hypertrophy and hyperplasia of smooth

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Helge Müller, Juliane Kröger, Olaf Jöhren, Silke Szymczak, Michael Bader, Peter Dominiak, and Walter Raasch

–pituitary–adrenal response to isolation stress . Endocrinology 142 3880 – 3889 . Baltatu O Silva JA Jr Ganten D Bader M 2000 The brain renin–angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy . Hypertension 35 409

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Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, and Shi-You Chen

was collected by direct cardiac puncture. Epididymal fat was carefully removed and weighed. A portion of the epididymal fat was fixed in 4% paraformaldehyde for histological analysis, whereas the other portion was stored at −80 °C for RNA and protein

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Ying-Ying Tsai, William E Rainey, and Wendy B Bollag

weights and inflammatory marker levels, mimicking the effects of a glucocorticoid (deoxycorticosterone), in an experimental rodent model of cardiac hypertrophy and fibrosis ( Young et al . 2003 ). These results suggest that endogenous glucocorticoid

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Takuro Okamura, Yoshitaka Hashimoto, Takafumi Osaka, Takafumi Senmaru, Takuya Fukuda, Masahide Hamaguchi, and Michiaki Fukui

. reported that androgen signals induce muscle hypertrophy through mTOR and the androgen receptor pathways ( Basualto-Alarcón et al. 2013 ). However, androgen replacement therapy has been reported to have several adverse effects ( Basualto-Alarcón et al

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Giampaolo Trivellin and Márta Korbonits

. 2009 ), and secondly, because AIP has been demonstrated to be essential in cardiac development and in maintaining productive erythropoiesis in mice ( Lin et al . 2007 , Kang et al . 2011 ) and previous studies in mammals and other eukaryotes showed

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Emilio Hirsch, Carlotta Costa, and Elisa Ciraolo

of MCIP1, a negative regulator of the NFAT transcription factor involved in cardiac hypertrophy ( Pedram et al. 2005 ). PI3K in Ang II signaling PI3K might also play a role in the signaling pathways triggered

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Adam Gesing, Andrzej Bartke, and Michal M Masternak

anti-diabetic effects of TZDs ( Nawrocki et al . 2006 ). Furthermore, the suppressive effects of PIO on angiotensin II-induced cardiac hypertrophy, as were seen in wild-type mice, were diminished in adiponectin-deficient mice ( Li et al . 2010