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A E Andreazzi, D X Scomparin, F P Mesquita, S L Balbo, C Gravena, J C De Oliveira, W Rinaldi, R M G Garcia, S Grassiolli, and P C F Mathias

represent s.e.m . Letters over bars represent significant differences with P <0.05 between groups: (a) control SED; (b) control EXE; (c) MSG SED, and (d) MSG EXE. Figure 4 shows that MSG obese animals present 60.5% decrease in insulin sensitivity, using

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Hans Eickhoff, Teresa Louro, Paulo Matafome, Raquel Seiça, and Francisco Castro e Sousa

patients with type 2 diabetes ( Seiça et al . 2003 , Portha et al . 2009 ). Thus, we studied the effect of common bariatric procedures such as sleeve gastrectomy and gastric bypass on glucose metabolism, insulin sensitivity, and pancreatic hormone

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Kok Lim Kua, Shanming Hu, Chunlin Wang, Jianrong Yao, Diana Dang, Alexander B Sawatzke, Jeffrey L Segar, Kai Wang, and Andrew W Norris

on insulin action and signaling. To accomplish our aim, we developed in vivo techniques to study rodent fetus glucose disposition, insulin sensitivity and insulin signaling. We examined three distinct aspects of fetal diabetes exposure: fetal

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Richard W Nelson and Claudia E Reusch

diabetes mellitus compared with cats with an optimal body weight ( Scarlett & Donoghue 1998 ). Experimental studies in healthy cats showed that an average weight gain of 1.9 kg during a feeding trial was associated with a decrease in insulin sensitivity of

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Edward Park, Victor Wong, Xinyu Guan, Andrei I Oprescu, and Adria Giacca

–euglycemic clamp was performed with tracer infusion during the last 2 h of the 7-h infusion period to assess hepatic and peripheral insulin sensitivity. During 30 min preceding the clamp (‘basal period’), measurements were taken at 10-min interval for plasma

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Eva Kassi and Athanasios G Papavassiliou

in a classic and in an osteoblast-specific manner, found an increase in β-cell proliferation, insulin secretion as well as insulin sensitivity – the latter through increasing the expression of adiponectin, an adipokine known to enhance insulin

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Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, and Liping Luo

sensitivity and lipid accumulation in vitro We further verified the regulatory function of miR-188 in insulin sensitivity and lipid accumulation through directly targeting hepatocytes. The insulin-stimulated phosphorylation of IR, AKT and GSK3β was

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Alice S Green, Paul J Rozance, and Sean W Limesand

Glucose-potentiated arginine-induced insulin secretion (GPAIS) – insulin response to a continuous i.v. glucose infusion followed by an i.v. arginine bolus Insulin sensitivity Capacity of insulin-responsive tissues (i.e. muscle, adipose, and liver) to

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Terese M Zidon, Jaume Padilla, Kevin L Fritsche, Rebecca J Welly, Leighton T McCabe, Olivia E Stricklin, Aaron Frank, Youngmin Park, Deborah J Clegg, Dennis B Lubahn, Jill A Kanaley, and Victoria J Vieira-Potter

adipocyte insulin signaling ( Campello et al. 2017 ). Insulin sensitivity of adipose tissue is critical to whole-body glucose regulation, particularly among women and older individuals who have a greater relative abundance of adipose tissue. However

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Mohamed Asrih and François R Jornayvaz

and has therefore been proposed as a potential target to reduce TG accumulation and hepatic steatosis. Indeed, inhibition of DGAT2 expression by antisense oligonucleotides reduced hepatic steatosis and improved insulin sensitivity in diet-induced obese