represent s.e.m . Letters over bars represent significant differences with P <0.05 between groups: (a) control SED; (b) control EXE; (c) MSG SED, and (d) MSG EXE. Figure 4 shows that MSG obese animals present 60.5% decrease in insulin sensitivity, using
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A E Andreazzi, D X Scomparin, F P Mesquita, S L Balbo, C Gravena, J C De Oliveira, W Rinaldi, R M G Garcia, S Grassiolli, and P C F Mathias
Hans Eickhoff, Teresa Louro, Paulo Matafome, Raquel Seiça, and Francisco Castro e Sousa
patients with type 2 diabetes ( Seiça et al . 2003 , Portha et al . 2009 ). Thus, we studied the effect of common bariatric procedures such as sleeve gastrectomy and gastric bypass on glucose metabolism, insulin sensitivity, and pancreatic hormone
Kok Lim Kua, Shanming Hu, Chunlin Wang, Jianrong Yao, Diana Dang, Alexander B Sawatzke, Jeffrey L Segar, Kai Wang, and Andrew W Norris
on insulin action and signaling. To accomplish our aim, we developed in vivo techniques to study rodent fetus glucose disposition, insulin sensitivity and insulin signaling. We examined three distinct aspects of fetal diabetes exposure: fetal
Richard W Nelson and Claudia E Reusch
diabetes mellitus compared with cats with an optimal body weight ( Scarlett & Donoghue 1998 ). Experimental studies in healthy cats showed that an average weight gain of 1.9 kg during a feeding trial was associated with a decrease in insulin sensitivity of
Edward Park, Victor Wong, Xinyu Guan, Andrei I Oprescu, and Adria Giacca
–euglycemic clamp was performed with tracer infusion during the last 2 h of the 7-h infusion period to assess hepatic and peripheral insulin sensitivity. During 30 min preceding the clamp (‘basal period’), measurements were taken at 10-min interval for plasma
Eva Kassi and Athanasios G Papavassiliou
in a classic and in an osteoblast-specific manner, found an increase in β-cell proliferation, insulin secretion as well as insulin sensitivity – the latter through increasing the expression of adiponectin, an adipokine known to enhance insulin
Ya Liu, Xiaoqing Zhou, Ye Xiao, Changjun Li, Yan Huang, Qi Guo, Tian Su, Lei Fu, and Liping Luo
sensitivity and lipid accumulation in vitro We further verified the regulatory function of miR-188 in insulin sensitivity and lipid accumulation through directly targeting hepatocytes. The insulin-stimulated phosphorylation of IR, AKT and GSK3β was
Alice S Green, Paul J Rozance, and Sean W Limesand
Glucose-potentiated arginine-induced insulin secretion (GPAIS) – insulin response to a continuous i.v. glucose infusion followed by an i.v. arginine bolus Insulin sensitivity Capacity of insulin-responsive tissues (i.e. muscle, adipose, and liver) to
Terese M Zidon, Jaume Padilla, Kevin L Fritsche, Rebecca J Welly, Leighton T McCabe, Olivia E Stricklin, Aaron Frank, Youngmin Park, Deborah J Clegg, Dennis B Lubahn, Jill A Kanaley, and Victoria J Vieira-Potter
adipocyte insulin signaling ( Campello et al. 2017 ). Insulin sensitivity of adipose tissue is critical to whole-body glucose regulation, particularly among women and older individuals who have a greater relative abundance of adipose tissue. However
Mohamed Asrih and François R Jornayvaz
and has therefore been proposed as a potential target to reduce TG accumulation and hepatic steatosis. Indeed, inhibition of DGAT2 expression by antisense oligonucleotides reduced hepatic steatosis and improved insulin sensitivity in diet-induced obese
