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Alpana Mathur, Vivek Kumar Pandey, and Poonam Kakkar

al . 2011 ). PHLPP and redox response Nrf2 has largely been explored as a major detox factor; however, it also has an important role in glucose metabolic programming. Reports indicate the involvement of Nrf2 in regulating enzymes of the non

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P Venditti, G Chiellini, L Di Stefano, G Napolitano, R Zucchi, A Columbano, T S Scanlan, and S Di Meo

protean equipment (Bio-Rad) for about 1 h at constant voltage (25 V). Separated hepatic proteins were transferred to nitrocellulose membranes by electroblotting. Membranes were incubated with a 1:1000 dilution of antibodies to PGC-1, NRF-1, and NRF-2

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Clara Lefranc, Malou Friederich-Persson, Roberto Palacios-Ramirez, and Aurelie Nguyen Dinh Cat

mice and administration of eplerenone corrected this decrease ( Hirata et al. 2009 ). The Nrf2 transcription factor (or NFE2L2) regulates genes involved in antioxidant defenses, including hemooxygenase 1 (HO1), SOD3, glutathione peroxidase (GPX

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Pongpan Tanajak, Siriporn C Chattipakorn, and Nipon Chattipakorn

shown by increased 3 nitrotyrosine (3NT) and 4 hydroxynonenal (4HNE). Second, increased nuclear factor (erythroid derived 2) like 2 (Nrf2) activated CD36 expression was seen, which led to increased plasma lipid uptake and accumulation into the cells

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Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Nami Kim, You Mi Kim, Hyeon Soo Kim, Eun Young Lee, and Choon Hee Chung

-arginase 2, anti-cluster of differentiation 68 (CD68), anti-nuclear factor, erythroid 2 like 2 (NRF2), anti-heme oxygenase1 (HO1), anti-NOX2, and anti-NOX4 (Santa Cruz Biotechnology), anti-β-actin, anti-nephrin (Abcam), anti-phospho (p)-AMPK, anti-p-P38, anti

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Sihan Lv, Xinchen Qiu, Jian Li, Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang, and Bing Luan

been reported that Mrp4 expression could be regulated by farnesoid X receptor (FXR) ( Schuetz et al . 2001 ), constitutive androstane receptor (CAR) ( Aleksunes & Klaassen 2012 ) and Nuclear Factor-E2-Related Factor-2 (NRF2) ( Maher et al . 2007

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Xiwen Xiong, Xupeng Sun, Qingzhi Wang, Xinlai Qian, Yang Zhang, Xiaoyan Pan, and X Charlie Dong

of PA-induced β-cell dysfunction and apoptosis ( Janikiewicz et al . 2015 ). A recent report has shown that SIRT6 can protect human mesenchymal stem cells from oxidative stress through regulation of nuclear factor erythroid 2-related factor 2 (NRF2

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Sergio Di Meo, Susanna Iossa, and Paola Venditti

biogenesis regulation was reached with the discovery of the transcription factors, nuclear respiratory factors 1 (NRF-1) ( Evans & Scarpulla 1990 ) and 2 (NRF-2) ( Virbasius et al. 1993 ). Further advancement was reached with the discovery of an inducible

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Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang, and Ye Jia

.1161/ATVBAHA.109.185694) 10.1161/ATVBAHA.109.185694 19286634 Pan C Zhou S Wu J Liu L Song Y Li T Ha L Liu X Wang F Tian J , et al . 2017 NRF2 plays a critical role in both self and EGCG protection against diabetic testicular damage . Oxidative Medicine

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Marika Bogdani, Angela M Henschel, Sanjay Kansra, Jessica M Fuller, Rhonda Geoffrey, Shuang Jia, Mary L Kaldunski, Scott Pavletich, Simon Prosser, Yi-Guang Chen, Åke Lernmark, and Martin J Hessner

. 1997 ), supporting a possible genetic basis for under-expression of antioxidant genes that remains to be elucidated in humans and BB rats. Gstm2 , Gstm4 , and Gstm7 are targets of NRF2 (NFE212) (nuclear factor E2 p45-related factor 2) ( Malhotra et