al . 2011 ). PHLPP and redox response Nrf2 has largely been explored as a major detox factor; however, it also has an important role in glucose metabolic programming. Reports indicate the involvement of Nrf2 in regulating enzymes of the non
Alpana Mathur, Vivek Kumar Pandey, and Poonam Kakkar
P Venditti, G Chiellini, L Di Stefano, G Napolitano, R Zucchi, A Columbano, T S Scanlan, and S Di Meo
protean equipment (Bio-Rad) for about 1 h at constant voltage (25 V). Separated hepatic proteins were transferred to nitrocellulose membranes by electroblotting. Membranes were incubated with a 1:1000 dilution of antibodies to PGC-1, NRF-1, and NRF-2
Clara Lefranc, Malou Friederich-Persson, Roberto Palacios-Ramirez, and Aurelie Nguyen Dinh Cat
mice and administration of eplerenone corrected this decrease ( Hirata et al. 2009 ). The Nrf2 transcription factor (or NFE2L2) regulates genes involved in antioxidant defenses, including hemooxygenase 1 (HO1), SOD3, glutathione peroxidase (GPX
Pongpan Tanajak, Siriporn C Chattipakorn, and Nipon Chattipakorn
shown by increased 3 nitrotyrosine (3NT) and 4 hydroxynonenal (4HNE). Second, increased nuclear factor (erythroid derived 2) like 2 (Nrf2) activated CD36 expression was seen, which led to increased plasma lipid uptake and accumulation into the cells
Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Nami Kim, You Mi Kim, Hyeon Soo Kim, Eun Young Lee, and Choon Hee Chung
-arginase 2, anti-cluster of differentiation 68 (CD68), anti-nuclear factor, erythroid 2 like 2 (NRF2), anti-heme oxygenase1 (HO1), anti-NOX2, and anti-NOX4 (Santa Cruz Biotechnology), anti-β-actin, anti-nephrin (Abcam), anti-phospho (p)-AMPK, anti-p-P38, anti
Sihan Lv, Xinchen Qiu, Jian Li, Jinye Liang, Weida Li, Chao Zhang, Zhen-Ning Zhang, and Bing Luan
been reported that Mrp4 expression could be regulated by farnesoid X receptor (FXR) ( Schuetz et al . 2001 ), constitutive androstane receptor (CAR) ( Aleksunes & Klaassen 2012 ) and Nuclear Factor-E2-Related Factor-2 (NRF2) ( Maher et al . 2007
Xiwen Xiong, Xupeng Sun, Qingzhi Wang, Xinlai Qian, Yang Zhang, Xiaoyan Pan, and X Charlie Dong
of PA-induced β-cell dysfunction and apoptosis ( Janikiewicz et al . 2015 ). A recent report has shown that SIRT6 can protect human mesenchymal stem cells from oxidative stress through regulation of nuclear factor erythroid 2-related factor 2 (NRF2
Sergio Di Meo, Susanna Iossa, and Paola Venditti
biogenesis regulation was reached with the discovery of the transcription factors, nuclear respiratory factors 1 (NRF-1) ( Evans & Scarpulla 1990 ) and 2 (NRF-2) ( Virbasius et al. 1993 ). Further advancement was reached with the discovery of an inducible
Hao Wu, Junduo Wu, Shengzhu Zhou, Wenlin Huang, Ying Li, Huan Zhang, Junnan Wang, and Ye Jia
.1161/ATVBAHA.109.185694) 10.1161/ATVBAHA.109.185694 19286634 Pan C Zhou S Wu J Liu L Song Y Li T Ha L Liu X Wang F Tian J , et al . 2017 NRF2 plays a critical role in both self and EGCG protection against diabetic testicular damage . Oxidative Medicine
Marika Bogdani, Angela M Henschel, Sanjay Kansra, Jessica M Fuller, Rhonda Geoffrey, Shuang Jia, Mary L Kaldunski, Scott Pavletich, Simon Prosser, Yi-Guang Chen, Åke Lernmark, and Martin J Hessner
. 1997 ), supporting a possible genetic basis for under-expression of antioxidant genes that remains to be elucidated in humans and BB rats. Gstm2 , Gstm4 , and Gstm7 are targets of NRF2 (NFE212) (nuclear factor E2 p45-related factor 2) ( Malhotra et
