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Sandra Pereira, Anu Shah, I George Fantus, Jamie W Joseph, and Adria Giacca

plasma FFA elevation increases from 7 to 48 h, oxidative stress in the liver is normalized. The underlying mechanism is unclear, but one possibility is that oxidative stress near the beginning of lipid infusion activates the transcription factor NRF2

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Laura Marroqui, Eva Tudurí, Paloma Alonso-Magdalena, Iván Quesada, Ángel Nadal, and Reinaldo Sousa dos Santos

signaling cascades culminates with the activation of transcription factors and co-regulators encoded by both nucleus and mitochondria. From the nuclear side, nuclear respiratory factors 1 and 2 (NRF1 and NRF2) are the two major transcription factors

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Zhe-Zhen Liao, Xiao-Yan Qi, Ya-Di Wang, Jiao-Yang Li, Qian-Qian Gu, Can Hu, Yin Hu, Heng Sun, Li Ran, Jing Yang, Jiang-Hua Liu, and Xin-Hua Xiao

, mitochondria biogenesis-markers, PGC-1α, NRF-1, NRF-2, and mtTFA remained upregulated in betatrophin-silenced 3T3-L1 adipocytes ( Fig. 3B and C ). In general, silencing betatrophin drove beiging process along with mitochondrial biogenesis in 3T3-L1 adipocytes

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You-Hua Xu, Chen-Lin Gao, Heng-Li Guo, Wen-Qian Zhang, Wei Huang, Shan-Shan Tang, Wen-Jun Gan, Yong Xu, Hua Zhou, and Quan Zhu

, nuclear factor erythroid 2-related factor 2 (Nrf-2) and mitochondrial modulated pathway ( Xing et al. 2016 , Dong et al. 2017 , Mollica et al. 2017 ). Previously, we also observed that SCFAs including butyrate can inhibit both high glucose- and LPS

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Apiwan Arinno, Nattayaporn Apaijai, Puntarik Kaewthep, Wasana Pratchayasakul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Siriporn C Chattipakorn, and Nipon Chattipakorn

manuscript, revision of the manuscript and final approval. References Abdelsalam RM Safar MM 2015 Neuroprotective effects of vildagliptin in rat rotenone Parkinson’s disease model: role of RAGE-NFkappaB and Nrf2-antioxidant signaling pathways

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Jiali Liu, Yue Li, Xiaoyan Zhou, Xi Zhang, Hao Meng, Sanyuan Liu, Lei Zhang, Juntao He, Qian He, and Yan Geng

-related genes (such as Nrf1 and Nrf2 expression), and coactivate several mitochondrial regulatory factors including Mef2 and Ppars ( Czubryt et al . 2003 , Wenz 2011 , 2013 ). In addition, NRF2 has been implicated in the control of Tfam expression

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Jin Sook Yoon, Hyun Jung Lee, Min Kyung Chae, Sang Yeul Lee, and Eun Jig Lee

A Rajendrasozhan S Caito S Yang SR Megson IL Rahman I 2008 Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells . American Journal

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Mauricio da Silva Krause, Aline Bittencourt, Paulo Ivo Homem de Bittencourt Jr, Neville H McClenaghan, Peter R Flatt, Colin Murphy, and Philip Newsholme

activation of Nrf2 transcription factor. Cytosolic NRF2 inhibiting protein (KEAP1) has a critical cysteine moiety, which is redox sensitive ( Gutierrez et al . 2008 ). The IL6-stimulated increase in the production of glutamate (a necessary amino acid for

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Chan-Juan Ma, Ai-Fang Nie, Zhi-Jian Zhang, Zhi-Guo Zhang, Li Du, Xiao-Ying Li, and Guang Ning

. American Journal of Physiology. Endocrinology and Metabolism 293 E286 – E292 . ( doi:10.1152/ajpendo.00693.2006 ) Jeon WK Hong HY Kim BC 2011 Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the

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A Santillo, L Burrone, S Falvo, R Senese, A Lanni, and G Chieffi Baccari

) and activates the production of NRF1 and NRF2. These two factors, of which NRF1 is the most important, are potent stimulators of the expression of TFAM, which is a potent stimulator of mitochondrial DNA duplication ( Puigserver et al . 1998 ). Thus