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Hyo Youl Moon, Parkyong Song, Cheol Soo Choi, Sung Ho Ryu, and Pann-Ghill Suh

accumulation of neutral lipids, mainly triglycerides (TGs), without ethanol consumption, viral infection, or other etiologies. NAFLD ranged from simple steatosis to cirrhosis accompanied by oxidative stress and hepatic injury ( Angulo 2002 ). Although the

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Changjie Han, Yan Jiao, Qingguo Zhao, and Baisong Lu

was the internal control. (G) Pgc1 , Ppar γ , Ucp1, and Ucp2 expression by quantitative RT-PCR. (H) Liver tissue from a+/+ male mouse on high-fat diet showing macrovesicular steatosis (hematoxylin and eosin stained). (I) Liver tissue from a tr

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Catalina Sierra-Ramos, Silvia Velazquez-Garcia, Arianna Vastola-Mascolo, Guadalberto Hernández, Nourdine Faresse, and Diego Alvarez de la Rosa

were stained with hematoxylin-eosin reagent. Sections were coded for unbiased examination. Liver steatosis was evaluated using a semiquantitative scale adapted from previously validated procedures ( Kleiner et al. 2005 ). To that end, images from

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Marco Colella, Valeria Nittoli, Alfonsina Porciello, Immacolata Porreca, Carla Reale, Filomena Russo, Nicola Antonino Russo, Luca Roberto, Francesco Albano, Mario De Felice, Massimo Mallardo, and Concetta Ambrosino

). Figure 5 Embryonic exposure to pesticides induces liver steatosis in a sex- and exposure-dependent manner. (A and B) Weight gain and length were measured in control (CTRL) and exposed zebrafish, from 6 hpf to the 180 dpf, males ( n  = 15) and females

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Elena Maneschi, Linda Vignozzi, Annamaria Morelli, Tommaso Mello, Sandra Filippi, Ilaria Cellai, Paolo Comeglio, Erica Sarchielli, Alessandra Calcagno, Benedetta Mazzanti, Roberto Vettor, Gabriella Barbara Vannelli, Luciano Adorini, and Mario Maggi

Cruz Biotechnology, Inc.). Densitometry analysis of band intensity was performed using the Photoshop 5.5 Software (Adobe Systems, Inc. Italia srl). Liver histology Liver steatosis was assessed by Oil Red O staining of the liver sections. Frozen sections

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Tristan S Allemann, Gursimran K Dhamrait, Naomi J Fleury, Tamara N Abel, Prue H Hart, Robyn M Lucas, Vance B Matthews, and Shelley Gorman

-fixed liver sections by blinded-scoring of formalin-fixed, stained liver sections for the degree of steatosis (H&E) and fibrosis (Masson’s) as previously described ( Kleiner et al . 2005 , Geldenhuys et al . 2014 , Fleury et al . 2017 , Teng et al

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L Francisco Lorenzo-Martín, Mauricio Menacho-Márquez, Salvatore Fabbiano, Omar Al-Massadi, Antonio Abad, Sonia Rodríguez-Fdez, María A Sevilla, María J Montero, Carlos Diéguez, Rubén Nogueiras, and Xosé R Bustelo

mice and the progressive development of SNS-associated dysfunctions such as hypertension, hypertension-associated morbidities (e.g., cardiovascular remodeling, kidney fibrosis), tachycardia, tachypnea, liver steatosis, insulin resistance, hyperlipidemia

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Shu-Fang Xia, Xiao-Mei Duan, Xiang-Rong Cheng, Li-Mei Chen, Yan-Jun Kang, Peng Wang, Xue Tang, Yong-Hui Shi, and Guo-Wei Le

hepatic steatosis possibly regulated by TH between OR and OP mice In the 7th week, hepatic TG levels of OP mice were increased significantly compared to those of Con and OR mice ( Fig. 5A ). When the mice were fed for a longer time, OP mice showed

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Eriko Inoue, Toshihiro Ichiki, Kotaro Takeda, Hirohide Matsuura, Toru Hashimoto, Jiro Ikeda, Aya Kamiharaguchi, and Kenji Sunagawa

in mice fed a HFD (data not shown). BPS attenuated HFD-induced hepatic steatosis Finally, we examined whether BPS affects hepatic steatosis induced by the HFD. HFD feeding for 12 weeks caused fatty liver compared with control feeding ( Fig. 4 A and B

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Naomi Fleury, Martin Feelisch, Prue H Hart, Richard B Weller, Jordan Smoothy, Vance B Matthews, and Shelley Gorman

resistance and less liver steatosis ( Geldenhuys et al . 2014 ). The beneficial effects of UVR on fasting glucose levels and liver steatosis were at least partially dependent on skin release of nitric oxide ( Geldenhuys et al . 2014 ). We exposed mice to