Search Results

Introduction Islet or pancreas transplantation is a promising approach to treat type 1 diabetes ( Shapiro et al . 2000 , Halban 2004 , Vaithilingam et al . 2008 , Ichii & Ricordi 2009 ). However, the limited supply of cadaveric pancreata and

. Annual Review of Immunology 23 447 – 485 . doi:10.1146/annurev.immunol.23.021704.115643 . Atkinson MA Eisenbarth GS 2001 Type 1 diabetes: new perspectives on disease pathogenesis and treatment . Lancet 358 221 – 229 . doi:10.1016/S0140

resistance is involved in the pathogenesis of type 2 diabetes mellitus (T2DM; Björnholm & Zierath 2005 ). In type 1 diabetes mellitus (T1DM), apart from its well-known pathogenesis, insulin resistance has also been described in both undertreated

Introduction Cell replacement therapies are potential alternatives to the insulin injections presently employed to control blood glucose in type 1 diabetes. Indeed, it has been demonstrated that this condition may be cured (at least

Introduction In the wake of improvements achieved by Shapiro et al. (2000) , human islet transplantation is now considered a potentially useful treatment modality for type 1 diabetes ( Korsgren et al. 2005 ). At present, however

2013 ). DM is a complex disease characterized by high blood glucose levels. There are two major forms of diabetes. Type 1 diabetes (T1D) results from a lack of insulin production in pancreatic β-cells. T2D is due to resistance to insulin, resulting in

Introduction Autoimmune destruction of pancreatic β cells during the development of type 1 diabetes is a complex process involving both cellular and humoral elements of cytotoxicity ( Mandrup-Poulsen et al . 1990 ). It is characterized by insulitis

mechanisms. The present study evaluated: (1) whether STVNa could ameliorate or inhibit the development and progression of type 1 diabetes-induced cardiac dysfunction; (2) whether the potential effect of STVNa was related to anti-hyperglycemia and/or AGE

maintain whole-body glucose homeostasis, at which point the patient presents with the clinical symptoms of type 1 diabetes. In brief, reduced circulating insulin causes decreased cellular uptake of glucose by peripheral tissues as well as hepatic

Introduction The introduction of insulin therapy for type 1 diabetes in the 1920s represented a monumental advance ( Banting et al . 1922 ). However, in spite of increasingly sophisticated approaches to regulating blood glucose with exogenous