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Jean-Claude Henquin, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, and Abner Louis Notkins

Hendricks W Notkins AL 2004 Targeted disruption of the IA-2β gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice . Diabetes 53 1684 – 1691 . Kubosaki A Nakamura S Notkins AL

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A K Katakam, G Chipitsyna, Q Gong, A R Vancha, J Gabbeta, and H A Arafat

et al. (2004) reported OPN among the genes specifically activated in the islets and lymph nodes in non-obese diabetic (NOD) mice. However, data concerning the early changes in OPN expression after diabetes induction and its functional significance

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Kleber L A Souza, Ewa Gurgul-Convey, Matthias Elsner, and Sigurd Lenzen

RF Szabo C Rabinovitch A 2001 An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice . Journal of Autoimmunity 16 449 – 455 . Tiedge M Lortz S Drinkgern J Lenzen S 1997

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J A Tamblyn, M Hewison, C L Wagner, J N Bulmer, and M D Kilby

NOD mice . Diabetes 51 1367 – 1374 . ( doi:10.2337/diabetes.51.5.1367 ) Griffin MD Lutz WH Phan VA Bachman LA McKean DJ Kumar R 2000 Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs

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Eduardo Esteban-Zubero, Francisco Agustín García-Gil, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, Pablo Iñigo-Gil, Dun-Xian Tan, José Joaquín García, and Russel J Reiter

concentrations and a reduction in membrane fluidity in pigs (García Gil et al. 2012). There are few studies related of the ability of melatonin to prevent pancreas graft rejection. It has been observed that in nonobese diabetic (NOD) mice, melatonin (200mg

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Shuang-Xia Zhao, Shanli Tsui, Anthony Cheung, Raymond S Douglas, Terry J Smith, and J Paul Banga

-cells sensitized with the human thyrotropin receptor, to naïve BALB/c and NOD mice . Endocrinology 135 4637 – 4643 doi:10.1210/en.137.11.4637 . Costagliola S Many MC Denef JF Pohlenz J Refetoff S Vassart G 2000 Genetic immunization of outbred

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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

MC Benencia F Malgor R Schwartz FL 2013 Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice . Molecules 18 3841

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Jia-Fwu Shyu, Hwai-Shi Wang, Yi-Ming Shyr, Shin-E Wang, Chia-Hsiang Chen, Joo-Shin Tan, Meng-Feng Lin, Po-Shiuan Hsieh, Huey-Kang Sytwu, and Tien-Hua Chen

HC Chi TC Chen CP Shyu JF Huang SW Shyr YM Tang KT Chen TH 2010 Transplantation of insulin producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice . Cell Transplantation (In Press) doi:10

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Stephen C Hanley, Béatrice Assouline-Thomas, Julia Makhlin, and Lawrence Rosenberg

therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice . Diabetes 54 2596 – 2601 . doi:10.2337/diabetes.54.9.2596 . Vinter-Jensen L Juhl CO Teglbjaerg PS Poulsen SS Dajani

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Sandra K Szlapinski, Anthony A Botros, Sarah Donegan, Renee T King, Gabrielle Retta, Brenda J Strutt, and David J Hill

to controls. This may have helped to enhance β-cell survival in the face of a higher cytokine environment, as has been observed in autoimmune diabetes in NOD mice ( Wang et al. 2008 ). The PD-L1 ligand has also been shown to be expressed in β