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concentrations and a reduction in membrane fluidity in pigs (García Gil et al. 2012). There are few studies related of the ability of melatonin to prevent pancreas graft rejection. It has been observed that in nonobese diabetic (NOD) mice, melatonin (200mg
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to controls. This may have helped to enhance β-cell survival in the face of a higher cytokine environment, as has been observed in autoimmune diabetes in NOD mice ( Wang et al. 2008 ). The PD-L1 ligand has also been shown to be expressed in β
