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A K Katakam, G Chipitsyna, Q Gong, A R Vancha, J Gabbeta, and H A Arafat

et al. (2004) reported OPN among the genes specifically activated in the islets and lymph nodes in non-obese diabetic (NOD) mice. However, data concerning the early changes in OPN expression after diabetes induction and its functional significance

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A Alidibbiat, C E Marriott, K T Scougall, S C Campbell, G C Huang, W M Macfarlane, and J A M Shaw

marrow without evidence of cell fusion . Journal of Clinical Investigation 111 843 – 850 . Kodama S Kuhtreiber W Fujimura S Dale EA Faustman DL 2003 Islet regeneration during the reversal of autoimmune diabetes in NOD mice . Science 302 1223

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J A Tamblyn, M Hewison, C L Wagner, J N Bulmer, and M D Kilby

NOD mice . Diabetes 51 1367 – 1374 . ( doi:10.2337/diabetes.51.5.1367 ) Griffin MD Lutz WH Phan VA Bachman LA McKean DJ Kumar R 2000 Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs

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Eduardo Esteban-Zubero, Francisco Agustín García-Gil, Laura López-Pingarrón, Moisés Alejandro Alatorre-Jiménez, Pablo Iñigo-Gil, Dun-Xian Tan, José Joaquín García, and Russel J Reiter

concentrations and a reduction in membrane fluidity in pigs (García Gil et al. 2012). There are few studies related of the ability of melatonin to prevent pancreas graft rejection. It has been observed that in nonobese diabetic (NOD) mice, melatonin (200mg

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Kleber L A Souza, Ewa Gurgul-Convey, Matthias Elsner, and Sigurd Lenzen

RF Szabo C Rabinovitch A 2001 An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice . Journal of Autoimmunity 16 449 – 455 . Tiedge M Lortz S Drinkgern J Lenzen S 1997

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Stephen C Hanley, Béatrice Assouline-Thomas, Julia Makhlin, and Lawrence Rosenberg

therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice . Diabetes 54 2596 – 2601 . doi:10.2337/diabetes.54.9.2596 . Vinter-Jensen L Juhl CO Teglbjaerg PS Poulsen SS Dajani

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Ashley Patton, Tyler Church, Caroline Wilson, Jean Thuma, Douglas J Goetz, Darlene E Berryman, Edward O List, Frank Schwartz, and Kelly D McCall

MC Benencia F Malgor R Schwartz FL 2013 Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice . Molecules 18 3841

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Jia Fang Wang and David J Hill

expressed the early transcription factor marker of endocrine and acinar cell commitment, PDX-1. Similar results were found for islet progenitor cells that budded from cultured ductal monolayers derived from adult NOD mice ( Ramiya et al . 2000 ). We found

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Manesh Chittezhath, Cho M M Wai, Vanessa S Y Tay, Minni Chua, Sarah R Langley, and Yusuf Ali

Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice . PNAS 114 E10418 – E10427 . ( https://doi.org/10.1073/pnas.1713543114 ) Carter JD Dula SB Corbin KL Wu R Nunemaker CS 2009

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James M Evans, Laura S Morris, and Julian R Marchesi

gut microbiota plays a role in the development of type 1 diabetes ( Wen et al . 2008 ). In this study, the islets of Langherans of germ-free, specific pathogen-free and altered Schaedler flora ( Dewhirst et al . 1999 ) Myd88 knockout NOD mice were