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Xiaoqin Shi, Xinyu Li, Yi Hou, Xuemei Cao, Yuyao Zhang, Heng Wang, Hongyin Wang, Chuan Peng, Jibin Li, Qifu Li, Chaodong Wu, and Xiaoqiu Xiao

following primary antibodies: p-STAT3 (1:1000, 9145, Tyr705) and STAT3 (1:1000, 9139) (Cell Signaling Technology), and suppressor of cytokine signaling 3 (SOCS3) (1:1000, ab16030), and then the secondary antibodies for 1 h at room temperature. The protein

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C Viguié, Y Chilliard, V Gayrard, N Picard-Hagen, P Monget, A Dutour, and P-L Toutain

. 2001 b ). Non-metabolic beneficial effects might arise from increased GH secretion. Indeed, GH exhibits IGF-I-independent neuroprotective effects ( Scheepens et al. 2001 ) and can induce the expression of suppressors of cytokine signalling

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Anshu Gupta, Malathi Srinivasan, Supaporn Thamadilok, and Mulchand S Patel

; Upstate Cell Signaling, Chicago, IL, USA), signal transducers and activators of transcription-3 (STAT-3; Cell Signaling Solutions, Lake Placid, NY, USA) and suppressors of cytokine signaling-3 (SOCS-3; Affinity BioReagents, Golden, CO, USA). Statistical

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Ke Cui, Giamal N Luheshi, and Patricia Boksa

hypothalamic suppressor of cytokine signaling 3 ( Socs3 ) mRNA, an indicator of IL-6 signaling pathway activation. Non-pregnant female and E15 pregnant rats ( n =7–8/experimental group) were injected i.p. with metyrapone (75 mg/kg) or its vehicle (40% propylene

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David J Flint, Nadine Binart, Stephanie Boumard, John J Kopchick, and Paul Kelly

showed it to be upregulated in lactation. They proceeded to show that PRL could induce suppressor of cytokine signaling proteins in adipocytes cultured in vitro , or in adipose tissue of PRL-transgenic mice, providing evidence for induction of

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Neele S Dellschaft, Marie-Cecile Alexandre-Gouabau, David S Gardner, Jean-Philippe Antignac, Duane H Keisler, Helen Budge, Michael E Symonds, and Sylvain P Sebert

-related peptide ( AgRP ); ii) insulin and leptin signaling: protein tyrosine phosphatase non-receptor type 1 ( PTP1B ( PTPN1 )), suppressor of cytokine signaling 3 ( SOCS3 ), insulin receptor ( IR ( INSR )), and leptin receptor ( obRb ( LEPR )); iii

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Mauricio da Silva Krause, Aline Bittencourt, Paulo Ivo Homem de Bittencourt Jr, Neville H McClenaghan, Peter R Flatt, Colin Murphy, and Philip Newsholme

Mooney RA 2003 Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes . Journal of Biological Chemistry 278 13740 – 13746 . doi:10.1074/jbc.M210689200 . Smukler SR Tang

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Kelly D McCall, Dawn Holliday, Eric Dickerson, Brian Wallace, Anthony L Schwartz, Christopher Schwartz, Christopher J Lewis, Leonard D Kohn, and Frank L Schwartz

inflammation and induce insulin resistance via multiple mechanisms including, but not limited to, serine phosphorylation of insulin receptor substrate-1 (IRS-1) and up-regulation of suppressors of cytokine signaling (SOCS; Paz et al . 1997 , Lin et al

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Sebastio Perrini, Luigi Laviola, Marcos C Carreira, Angelo Cignarelli, Annalisa Natalicchio, and Francesco Giorgino

receptor and translocation to the nucleus, with subsequent binding to DNA and regulation of gene expression. Among the target genes, GH regulates the expression of suppressor of cytokine signaling (SOCS), a family of negative regulators that terminate the

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Mohamed Asrih and François R Jornayvaz

, such as the JAKs/STATs. Thereafter, JAK activation induces STAT phosphorylation, dimerization, and translocation to the nucleus, leading to transcription of several genes, such as the suppressor of cytokine signaling ( SOCS ), which is known to alter